DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and rpk

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001246909.1	Gene:	rpk / 40580	FlyBaseID:	FBgn0022981	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	212/575 - (36%)
Similarity:	324/575 - (56%)	Gaps:	72/575 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 DVIIKSRIRYGSPLSACKGLLL---EYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVS 107
            |:..:.|.:.||  .||:|.:.   ||.::|:|||::|:.|..||..|:::|||...||:|...:
  Fly    15 DLTFRRRRKAGS--VACEGFITTYHEYCRNTSIHGVQYLGEQERPFRERIFWLFVFLISIYGCST 77

  Fly   108 LIWDTYLKWQESPVILGFDETLVPVHKIPFPTITICPE----IKMERNVFDYTNVSRQLWEEYKQ 168
            ||...|.||.|:|||:.|.|...||..||||.:|:|.|    :|.:.....|.::..|..|:.:.
  Fly    78 LIQSAYTKWTETPVIVSFAEKSTPVWNIPFPAVTVCSETKRVLKQKGKETTYADLYSQFSEDMRA 142

  Fly   169 N-----GNISDLDDEDLARMAVAMHICDSEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGP 228
            :     .|:|.|:.|:...:   :|:|::::::...||::..:....||.|.::          |
  Fly   143 SRVFRPENVSALEMEEFRTL---LHVCNTQIIEEDIPLIAGDDLDYFDVLQRML----------P 194

  Fly   229 -------FCKWNGRFYFCDKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFD 286
                   :|:|..||..|:..|....|:|||||.|||||..:||||:.:            :|..
  Fly   195 QFDRYFFYCRWLSRFGECETFFRKTLTEEGICYTFNGLRATEIYRDDTY------------QYQH 247

  Fly   287 VDLP-PWNNITGN---WSLDTGF-VDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQ 346
            ...| ...||:..   |:|:||: :|.....:|.|.:.:..::|.|..||..:...||.||...|
  Fly   248 SGEPLEMENISSQHTAWTLETGYALDSDVETFPARVLSAGARSGIFLALQSFKQEVDYACRGPVQ 312

  Fly   347 GYK------VFLNSPESVPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDER 405
            |:|      |.|::|:.||..:..::.:|.|.|||::|.|..:..:..:.|..|.:|||....||
  Fly   313 GFKVGKFENVLLHAPDDVPQVSKQFVRIPMGKEVLIAVKPNMITMSSGIAEYHPVRRQCFLSHER 377

  Fly   406 SLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKDINCYTSAQDELYTLMQNQT 470
            |||||:.|::||||.|||||:|::||||.||.||:.:..||||...|:||..|:.||  |::...
  Fly   378 SLRFFKVYTESNCQLECLANFTLTKCGCVKFSMPRNVDMPVCGEDKIHCYDRAEREL--LVREFK 440

  Fly   471 MAKSID------ESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRA-----FREEYEHTDAIGS 524
            ..|:::      .||:..||||||||||.||.|||:|.:|:.:.:.|     |.:||..:..  |
  Fly   441 RVKALNAGRENSRSVESACNCMPACTSLVYNTEISQANFDLEEMLVAEGDTEFLKEYPGSQM--S 503

  Fly   525 RLSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCMRI 579
            |||:|||:.||...||:.|:|::..::|||||.|||||.|.||.:|:||.|.:|:
  Fly   504 RLSIYFKQSQFITSKRSELYGMTEFLANCGGIFGLFMGFSILSLVEMIYHFTLRL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	201/542 (37%)
rpk	NP_001246909.1	ASC	39..552	CDD:279230	200/541 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450001
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900