Protein Alignment ppk and ASIC2

DIOPT Version :9

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 127/603 - (21%)
• Similarity: 198/603 - (32%)
• Gaps: 198/603 - (32%)

  Fly    54 RYGSP-LSACKGLLLEYAKSTTIHGIRYI----------FEVHRPIYEKLYWLFFTCISVYFAVS 107
            |.|.| ||..|           :||:|::          |:      .:..|:...|.|  |.:.
Human    55 RRGRPSLSRAK-----------LHGLRHMCAGRTAAGGSFQ------RRALWVLAFCTS--FGLL 100

  Fly   108 LIWDT--YLKWQESPVILGFDETLVPVHK-----IPFPTITICPEIKMERNVFDYTNVSRQLWEE 165
            |.|.:  .|.|...|       :...||:     :|||.:|:|     ..|...:..:|:  .:.
Human   101 LSWSSNRLLYWLSFP-------SHTRVHREWSRQLPFPAVTVC-----NNNPLRFPRLSK--GDL 151

  Fly   166 YKQNGNISDLDDEDLARMAVAMHICDSEVVQRFTPLLSQLN---PPN---------VD-VTQTLI 217
            |.....:..|.....||..|:..:...|..:::...|:...   ||.         :| :...|.
Human   152 YYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLE 216

  Fly   218 DLSISKNETGPFCKWNGRFYFC-DKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDF 281
            |:.:|       ||:.|.  .| ...|..|.|..|.||.||
Human   217 DMLLS-------CKYRGE--LCGPHNFSSVFTKYGKCYMFN------------------------ 248

  Fly   282 NKYFDVDLPPWNNITGNWSLDTGFVDQGQNAYP-QRTVFSSVKNGFFAFLQGLQHNF-----DYD 340
                                      .|::..| ..||.....||....|...|..:     :.:
Human   249 --------------------------SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETE 287

  Fly   341 CRSFKQGYKVFLNSPESVPLTTGNYILVPHGDEVLVSVLPAY--VVST--DNLHEITPEKRQCLF 401
            ..:|:.|.||.::| :|.|         |...|:...|.|.:  .|:|  ..|..:.|...:|.
Human   288 ETTFEAGVKVQIHS-QSEP---------PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR- 341

  Fly   402 DDERSLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMP-----------KPLGTPVCGL---KDI 452
            ..|..|.||..||.:.|:.:|...|.|..|.|....||           |....|..||   ||.
Human   342 SSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDS 406

  Fly   453 NCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYE 517
            |                            .|.|...|....||.|:|..|.....:.:...:::.
Human   407 N----------------------------YCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFN 443

  Fly   518 HTDAIGSR----LSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELI-YFF-- 575
            .::...|.    |.::|:...:..|::...:.|:.|:.:.||..|||:|.|.|:.|||. |.:
Human   444 KSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYEL 508

  Fly   576 ----CMRICGSCRDRRKH 589
                .:.:.|...|...|
Human   509 IKEKLLDLLGKEEDEGSH 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	117/564 (21%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	122/594 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.970