DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and ppk12

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	141/569 - (24%)
Similarity:	239/569 - (42%)	Gaps:	120/569 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RYGSPLSACKGL---LLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLK 115
            |.||.|...|..   |.::...|::||::::.:.....:|:.::|.....::...|.||.:.|:|
  Fly    11 RQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVK 75

  Fly   116 WQESPVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDL 180
            |..:|||:|.......:.|:|||.||||          :...|.|.|...|::..|.|
  Fly    76 WDSTPVIIGISPQATSILKVPFPAITIC----------NMNQVQRSLVANYREGSNES------- 123

  Fly   181 ARMAVAMHICD------SEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGPFCKWNGRFYFC 239
               |:...:|:      ||..:.|:  .|.....|:.:::.:.:.|.|......||:::.....|
  Fly   124 ---ALLKLLCESDSWESSEADEEFS--ASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNC 183

  Fly   240 DKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGN------ 298
            .::|..:.||||:|..||...|:.:|:                        |:.|...|
  Fly   184 SQLFQQILTDEGLCCVFNFQPPEYLYK------------------------PFANNNRNLTNSDG 224

  Fly   299 -----WSLDTGFVDQ-GQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFK-QGYKVFLNSPE 356
                 |..::|:.:| ....||.....:.:..||.|.|..  ...:|.|.|.. .|:||:.::|.
  Fly   225 FESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDA--EMGEYYCSSTNGPGFKVYFHNPI 287

  Fly   357 SVPLTTGNYILVPHGDE-------VLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYS 414
            .||......::...|.|       |....:||       :..|:.:.|||||.:|:.|.|:|.|:
  Fly   288 EVPKVKEAGLISAIGYETNYRIEMVRAEAVPA-------IRSISRDGRQCLFKNEKELIFYRIYT 345

  Fly   415 QSNCQTECLANYTVSKCGCAKFWMPKPL---GTPVCGLKDINCYTSAQDELYTLMQNQTMAKSID 476
            :.||:.||||.:....|.|..|  ..||   ...:|.:.|.:|...||    ........||...
  Fly   346 RLNCENECLAAFLYDTCSCIPF--DHPLIYSNASICSMGDTSCVRRAQ----RASNRPGWAKCRQ 404

  Fly   477 ESVDITCNCMPACTSLEY------------NFEISRAKYDVAKTIRAFREEYEHTDAIGSRLSVY 529
            :       |:|:|..|.|            ||:::.|      .:.:|.:.|...:.  :.::||
  Fly   405 Q-------CLPSCFDLNYLASGFSFPLASNNFQLANA------LVESFNKSYLSKNI--AVINVY 454

  Fly   530 FKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCMR 578
            |:|..:....:....|::..:||.||:.|||||.|.:|..|::||..::
  Fly   455 FRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	133/545 (24%)
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	133/546 (24%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	133/545 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456758
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900