DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and ppk28

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	592	Identity:	151/592 - (25%)
Similarity:	256/592 - (43%)	Gaps:	100/592 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RASIASAALSDVPSD---VIIKSRIRYGSPLSACKGLLLEYAKSTTIHGIRYIFEVHRPIYEKLY 93
            |.|.:|....|..||   ..|.||       :|.|..::.|.|::|:||::||.|....|.|:::
  Fly    10 RQSGSSGCKKDSESDDDENTICSR-------AAIKRSVVYYLKNSTLHGLKYIAEESITIPERIF 67

  Fly    94 WLFFTCISVYFAVSLIWDTYLKWQESPVILGFDETLVPVHKIPFPTITICPEIKMERNVFDYTNV 158
            :.....:.|..:|..|.:.|:||..||:|:...........:|||.||||             |:
  Fly    68 FGLAFVLVVILSVFFISNVYVKWSASPIIISTSAKQKLTSNMPFPAITIC-------------NL 119

  Fly   159 SRQLWEEYKQNGNISDLDDEDLARMAVAMHICDS---------EVVQRFTPLLSQLNPPNVDVTQ 214
            ::.|..:..:.|..|       ...::.|.:||.         ...:.|..:|       |||.|
  Fly   120 NQALLSKVDRIGRTS-------TNFSLLMGLCDQGGDTTISYIGTWKYFKAIL-------VDVAQ 170

  Fly   215 TLIDLSISKNETGPFCKWNGRFYFCDKIFDFVATDEGICYQFNGLRPKDI---YRDEKFISYVDP 276
            ....:.:       :|.:..|...|..:|..:.||:|:|..||.|.|..:   |.|:..:....|
  Fly   171 PCEKMLL-------YCSFGSREEDCSWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHP 228

  Fly   277 DVVDFNKYFDVDLPPWNNITGNWSLDTGFVDQGQNAY-PQRTVFSSVKNGFFAFLQGLQHNFDYD 340
            :    .:|..:|          |:.:.|:.......| |:.:..:.::.|....|......: |.
  Fly   229 N----TRYELID----------WTPEKGYARNLPEFYFPRTSGGTGIRMGLTVVLNASIAEY-YC 278

  Fly   341 CRSFKQGYKVFLNSPESVPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDER 405
            .:|...|:||.:::|..:|..:....:|..|.|..:.:.|.|..:...:..|....|:|||.||.
  Fly   279 TKSMSVGFKVLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDEN 343

  Fly   406 SLRFFRSYSQSNCQTECLANYTVSKCGCAKFWMPK--PLGTPVCGLKDINCYTSAQDELYTLMQN 468
            .|.::|:||:.||:.||.|...:.:|.|..:::|:  ||.. |||..|..|....|.|:.:.:.|
  Fly   344 DLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPRIDPLAR-VCGPNDNQCTDRVQTEIESSLTN 407

  Fly   469 QTMAKSIDESVDITC-NCMPACTSLEYNFEISRA------KYDVAKTI--RAFREEYEHTDAIGS 524
                        ::| ||.|.|..|.|...:|.|      ::...:.:  ..|...|.:...| |
  Fly   408 ------------LSCENCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIFHGPYSNASEI-S 459

  Fly   525 RLSVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCMR-ICGS--CRDR 586
            .|..|:..:.|.:..::.:||.:..:||.||:.|||||.|..|.:|:.::..:| .|.|  .|.|
  Fly   460 ILHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVRPYCASRTLRQR 524

  Fly   587 RKHKIQQ 593
            .|.:::|
  Fly   525 HKRRLEQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	133/528 (25%)
ppk28	NP_573169.2	ASC	43..509	CDD:279230	133/528 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456755
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900