DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and Asic2

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_037024.2	Gene:	Asic2 / 25364	RGDID:	2017	Length:	563	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	133/625 - (21%)
Similarity:	207/625 - (33%)	Gaps:	191/625 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KSGISILPGPELLALPG-----FDTRASIASAALSDVPSDVIIKSRIRYGSPLSACKGLLLEYAK 71
            :||.:.||...|.. ||     .:..|.:|.||......|       |.|.|.....|:......
  Rat     3 RSGGARLPATALSG-PGRFRMAREQPAPVAVAAARQPGGD-------RSGDPALQGPGVARRGRP 59

  Fly    72 S---TTIHGIRYI----------FEVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLKWQESPVIL 123
            |   |.:||:|::          |:      .:..|:...|.|:...:|...:..|.|...|
  Rat    60 SLSRTKLHGLRHMCAGRTAAGGSFQ------RRALWVLAFCTSLGLLLSWSSNRLLYWLSFP--- 115

  Fly   124 GFDETLVPVHK-----IPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARM 183
                :...||:     :|||.:|:|     ..|...:..:|:  .:.|.....:..|.....||.
  Rat   116 ----SHTRVHREWSRQLPFPAVTVC-----NNNPLRFPRLSK--GDLYYAGHWLGLLLPNRTARP 169

  Fly   184 AVAMHICDSEVVQRFTPLLSQLN---PPN---------VD-VTQTLIDLSISKNETGPFCKWNGR 235
            .|:..:...|..:::...|:...   ||.         :| :...|.|:.:|       ||:.|.
  Rat   170 LVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLS-------CKYRGE 227

  Fly   236 FYFC-DKIFDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGNW 299
              .| ...|..|.|..|.||.||
  Rat   228 --LCGPHNFSSVFTKYGKCYMFN------------------------------------------ 248

  Fly   300 SLDTGFVDQGQNAYP-QRTVFSSVKNGFFAFLQGLQHNF-----DYDCRSFKQGYKVFLNSPESV 358
                    .|::..| ..||.....||....|...|..:     :.:..:|:.|.||.::| :|.
  Rat   249 --------SGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHS-QSE 304

  Fly   359 PLTTGNYILVPHGDEVLVSVLPAY--VVST--DNLHEITPEKRQCLFDDERSLRFFRSYSQSNCQ 419
            |         |...|:...|.|.:  .|:|  ..|..:.|...:|. ..|..|.||..||.:.|:
  Rat   305 P---------PFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-SSEMGLDFFPVYSITACR 359

  Fly   420 TECLANYTVSKCGCAKFWMP-----------KPLGTPVCGL---KDINCYTSAQDELYTLMQNQT 470
            .:|...|.|..|.|....||           |....|..||   ||.|
  Rat   360 IDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSN----------------- 407

  Fly   471 MAKSIDESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSR----LSVYFK 531
                       .|.|...|....||.|:|..|.....:.:...:::..::...|.    |.::|:
  Rat   408 -----------YCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFE 461

  Fly   532 EHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLEL 571
            ...:..|::...:.|:.|:.:.||..|||:|.|.|:.|||
  Rat   462 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASLLTILEL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	117/563 (21%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	116/556 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020