DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk and Scnn1a

DIOPT Version :9

Sequence 1:	NP_477232.1	Gene:	ppk / 34843	FlyBaseID:	FBgn0020258	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_113736.1	Gene:	Scnn1a / 25122	RGDID:	3639	Length:	699	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	121/565 - (21%)
Similarity:	211/565 - (37%)	Gaps:	117/565 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YAKSTTIHG-IRYIFEVHRPIYEKLYWLFFTCI--SVYFAVSLIWDTYLKWQESPVILGFDETLV 130
            :..:||||| ||.:...|..:....:.:.:.|.  .:|:..:|:::.||.:   ||.|..:   :
  Rat    88 FCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSY---PVSLNIN---L 146

  Fly   131 PVHKIPFPTITIC-------PEIKMERNVFDYTNVSRQ-LWEEYKQNGNISDLDDEDLARMAVAM 187
            ...|:.||.:|:|       .|||.|....|  .::.| |::.||.|.:.:        |.|.|.
  Rat   147 NSDKLVFPAVTVCTLNPYRYTEIKEELEELD--RITEQTLFDLYKYNSSYT--------RQAGAR 201

  Fly   188 HICDSEVVQRFT-PLLSQLNPPNVDVTQTLIDLSISKNETGPFC---KWNGRFYFCDKIFDFVAT 248
            .....:::..|. ||.....||.....:|....|.|..:..|..   .|...|..|::
  Rat   202 RRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQ------- 259

  Fly   249 DEGICYQFNGLRPKDIYRDEKFISYVD---------PDVVD-----------FNK-------YFD 286
            ::..|:........|..|:.....|::         |.:.:           ||:       |..
  Rat   260 NKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTCRFNQAPCNQANYSK 324

  Fly   287 VDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVF 351
            ...|.:.|.       ..|.|: .|:....:....|.||....|:..|::| ....|...|.:|.
  Rat   325 FHHPMYGNC-------YTFNDK-NNSNLWMSSMPGVNNGLSLTLRTEQNDF-IPLLSTVTGARVM 380

  Fly   352 LN-SPESVPLTTGNYILVPHGD-------EVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLR 408
            :: ..|...:..|.:.|.|..:       |.|.|:...|...|:|..:: |.|.  |:..:
  Rat   381 VHGQDEPAFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDV-PVKN--LYPSK---- 438

  Fly   409 FFRSYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKDIN----CYTSAQDELYTLMQNQ 469
                |:|..|...|.....:.|||||..:.|||.|...|..:..:    ||...|.
  Rat   439 ----YTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYRKQSSWGYCYYKLQG--------- 490

  Fly   470 TMAKSIDESVDITCNCMPACTSLEYNFEISRAKYDVAKT------IRAFREEYEHTDAIG--SRL 526
              |.|:| |:.....|...|:.:.|......:::...|:      :.:.:..|...:...  ::|
  Rat   491 --AFSLD-SLGCFSKCRKPCSVINYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKL 552

  Fly   527 SVYFKEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLEL 571
            :::|||..:.....:....:.:|:||.|....|:.|.|.||.:|:
  Rat   553 NIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEM 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	121/565 (21%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	121/565 (21%)
Scnn1a	NP_113736.1	deg-1	88..600	CDD:273309	121/565 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870