DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk and Scnn1g

DIOPT Version :10

Sequence 1:NP_477232.1 Gene:ppk / 34843 FlyBaseID:FBgn0020258 Length:606 Species:Drosophila melanogaster
Sequence 2:NP_035456.1 Gene:Scnn1g / 20278 MGIID:104695 Length:655 Species:Mus musculus


Alignment Length:627 Identity:128/627 - (20%)
Similarity:210/627 - (33%) Gaps:174/627 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 IKSRIRYGSPL-----SACKGLLLEYAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSL 108
            ||::|:...|:     ...|.|:..|..:|..||.|.|. |.|....:|.|:.||..:|...:  
Mouse     7 IKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRIV-VSRGRLRRLLWIAFTLTAVALII-- 68

  Fly   109 IWDTYLKWQESPVILGFDETLVPV----HKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQN 169
                   ||.:.::..|....|.:    .|:.||.:|||     ..|.:.|:.||..|       
Mouse    69 -------WQCALLVFSFYTVSVSIKVHFQKLDFPAVTIC-----NINPYKYSAVSDLL------- 114

  Fly   170 GNISDLDDEDLARMAVAMHICDSEVVQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGPF-CKWN 233
               :||               |||..|....|..        |...|......:.|.|.. ..|.
Mouse   115 ---TDL---------------DSETKQALLSLYG--------VKDVLDSTPRKRREAGSMRSTWE 153

  Fly   234 G---RFYFCDKIFDFVATDEGICYQ-FNGLRPK-------------DIYRDEKFISY--VDPDVV 279
            |   ||.....:..|...::|.... |.|.:.|             .::..:|.:.:  ...|..
Mouse   154 GTPPRFLNLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTS 218

  Fly   280 DFNKY-FDVDLPPWNNITGNWSLDTGFVDQGQNAYPQRTVFSSVKNGFFA-------FLQGLQ-- 334
            |...| |...:    |....|     :.....|...|..:...:...:.|       |..|:.  
Mouse   219 DCATYTFSSGI----NAIQEW-----YKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCD 274

  Fly   335 -HNFDY-------DCRSF----------------KQGYKV--FLNSPESVPL---TTGNYILVPH 370
             .||..       :|.:|                :.|.:|  ::|..|..|.   :||..:||..
Mouse   275 ARNFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLVHQ 339

  Fly   371 ----------GDEVLVSVLPAYVVSTDNLHEITPEKRQCLFD--DERSLRFFR-SYSQSNCQTEC 422
                      |.|:..::..:..:......:::....||..|  |......:. :||...|...|
Mouse   340 QNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSC 404

  Fly   423 LANYTVSKCGCAKFWMPKPLGTPVCGLKD----INCYTSAQDELYTLMQNQTMAKSIDESVDITC 483
            .....|.|||||::..|.|.....|..:.    :.||       |.|.|     ..:.|.:....
Mouse   405 FQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCY-------YQLYQ-----AFVREELGCQS 457

  Fly   484 NCMPACTSLEYNFEISRAK---------------YDVAKTIRAFREEYEHTDAIGSRLSVYFKEH 533
            .|..:|:..|:....|.|:               :|.::.|   .::...||.  ::|.:::|:.
Mouse   458 VCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQI---NKKLNKTDL--AKLLIFYKDL 517

  Fly   534 QFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFF 575
            ...:|..:....:..|:||.||..||:|..|.:..:|:|..|
Mouse   518 NQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVF 559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppkNP_477232.1 ASC 69..574 CDD:459966 121/599 (20%)
Scnn1gNP_035456.1 ENaC 24..636 CDD:273304 124/610 (20%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:15007080, ECO:0000305|PubMed:18650438 140..227 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..636
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170 629..633
Blue background indicates that the domain is not in the aligned region.

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