Protein Alignment ppk and mec-4

DIOPT Version :9

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_510712.2
• Gene: mec-4 / 181728
• WormBaseID: WBGene00003168
• Length: 768
• Species: Caenorhabditis elegans
• Alignment Length: 678
• Identity: 124/678 - (18%)
• Similarity: 216/678 - (31%)
• Gaps: 196/678 - (28%)

  Fly    68 EYAKSTTIHGIRYIFEVHRPIYEKLYW--LFFTC-ISVYFAVSLIWDTYLKWQE-SPVILGFDET 128
            |:...|:.|||..|.|... :|.:..|  ||..| |.:|.....:.|.|.:.:: ..:.|.||..
 Worm    86 EFCYKTSAHGIPMIGEAPN-VYYRAVWVVLFLGCMIMLYLNAQSVLDKYNRNEKIVDIQLKFDTA 149

  Fly   129 LVPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEY-----KQNGNISDLDDE---------- 178
                   |||.||:|.....:.::....::.::....:     |..|| .|.::|
 Worm   150 -------PFPAITLCNLNPYKASLATSVDLVKRTLSAFDGAMGKAGGN-KDHEEEREVVTEPPTT 206

  Fly   179 --------------DLA----RMAVAMHICDS---------------EVVQRFTPLLSQLNPP-- 208
                          ||:    ....|..:|.|               |:::..|..:..:|..
 Worm   207 PAPTTKPARRRGKRDLSGAFFEPGFARCLCGSQGSSEQEDKDEEKEEELLETTTKKVFNINDADE 271

  Fly   209 ----------------NVDVTQTLIDLSISKNETGPFCKWNGRFYFCDKIFDFVATDEGICYQFN 257
                            :|:.|..:..:...::|...|.:..|....|...||....|...|: .|
 Worm   272 EWDGMEEYDNEHYENYDVEATTGMNMMEECQSERTKFDEPTGFDDRCICAFDRSTHDAWPCF-LN 335

  Fly   258 G---LRPKDIYRDEKFIS--------YVDPDVVDFNKY---FDVDLPP---WNNITGNW-SLDTG 304
            |   ....|...:..|.:        :..|.:...:::   ::...||   |..:.|.. :.|..
 Worm   336 GTWETTECDTCNEHAFCTKDNKTAKGHRSPCICAPSRFCVAYNGKTPPIEIWTYLQGGTPTEDPN 400

  Fly   305 FVD----QGQN--------------------AYPQRTVFSSVK---------NG----------- 325
            |::    ||..                    :...|...|:.|         ||
 Worm   401 FLEAMGFQGMTDEVAIVTKAKENIMFAMATLSMQDRERLSTTKRELVHKCSFNGKACDIEADFLT 465

  Fly   326 --------FFAFLQGLQHNFDYDCRSFKQG------YKVFLNSPESVPLT--TGNYILV------ 368
                    .|.|    .||...:..|.:.|      ..|::|:.:.:|.|  ||..:.:
 Worm   466 HIDPAFGSCFTF----NHNRTVNLTSIRAGPMYGLRMLVYVNASDYMPTTEATGVRLTIHDKEDF 526

  Fly   369 PHGDEVLVSVLPAYVVS----TDNLHEITPEKRQCLFDDERSLRFFRSYSQS--NCQTECLANYT 427
            |..|....|....||.|    ...:..:......|:.|.:.|...:.:|..|  .|...|.....
 Worm   527 PFPDTFGYSAPTGYVSSFGLRLRKMSRLPAPYGDCVPDGKTSDYIYSNYEYSVEGCYRSCFQQLV 591

  Fly   428 VSKCGCAKFWMPKPLGTPVCGLKD---INCYTSAQDELYTLMQNQTMAKSIDESVDITCNCMPAC 489
            :.:|.|.....|.|.....|...|   ..|..:..::|..|..:            ..|.|...|
 Worm   592 LKECRCGDPRFPVPENARHCDAADPIARKCLDARMNDLGGLHGS------------FRCRCQQPC 644

  Fly   490 TSLEYNFEISRAKY-------DVAKTIRAFREEYEHTDAIGSRLSVYFKEHQFTAIKRTILFGVS 547
            ....|:...|.||:       .:........|..:|....|:.:.|::::..|..:..:..:|..
 Worm   645 RQSIYSVTYSPAKWPSLSLQIQLGSCNGTAVECNKHYKENGAMVEVFYEQLNFEMLTESEAYGFV 709

  Fly   548 TLISNCGGICGLFMGISCLSFLELIYFF 575
            .|:::.||..||:.|||.|:..|.::.|
 Worm   710 NLLADFGGQLGLWCGISFLTCCEFVFLF 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:279230	122/674 (18%)
mec-4	NP_510712.2	deg-1	86..736	CDD:273309	123/675 (18%)
		ASC	87..>172	CDD:279230	24/92 (26%)
		ASC	<428..739	CDD:295594	63/326 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7852
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.770