Protein Alignment ppk and Asic3

DIOPT Version :10

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: XP_006535700.1
• Gene: Asic3 / 171209
• MGIID: 2159339
• Length: 563
• Species: Mus musculus
• Alignment Length: 596
• Identity: 125/596 - (20%)
• Similarity: 199/596 - (33%)
• Gaps: 156/596 - (26%)

  Fly    69 YAKSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSLIWDTYLKWQESPVILGFDETLVPVH 133
            :|.|.|:||:.:||........:..|.....:|:...:..:.:....:.|.......||.  ..|
Mouse    21 FANSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDER--ESH 83

  Fly   134 KIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARMAVAMHICDSEVVQRF 198
            ::.||.:|:|       |:    |..|:           |.|...||.....|:...|......:
Mouse    84 QLTFPAVTLC-------NI----NPLRR-----------SRLTPNDLHWAGTALLGLDPAEHAAY 126

  Fly   199 TPLLSQ-------LNPPNVDVTQTLIDLSISKNETGPFCKWNGRFYFC-DKIFDFVATDEGICYQ 255
            ...|.|       :..|..|:.|.......|..:....|::.|:  .| .:.|..:.|..|.||.
Mouse   127 LRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQ--PCGPENFTVIFTRMGQCYT 189

  Fly   256 FNG--------LRPK-----------DIYRDEKFISYVDPDVVDFNKYFDVDL-----PPWNNIT 296
            ||.        ..||           |:.::|....:.|.:...|.....|.:     ||
Mouse   190 FNSGAQGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHGQEEPP----- 249

  Fly   297 GNWSLDTGFVDQ-GQNAYPQRTVFSSVKNGFFAFLQGLQHNFDYDCRSFKQGYKVFLNSPESVPL 360
                    .:|| |..|.|....|.|.:....:||.
Mouse   250 --------AIDQLGFGAAPGHQTFVSCQQQQLSFLP----------------------------- 277

  Fly   361 TTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLFDDERSLRFFRSYSQSNCQTECLAN 425
                   .|.||....||.|          :..||....|.....|    ..||...|:..|.:.
Mouse   278 -------PPWGDCNTASVDP----------DFDPEPSDPLGSPSSS----PPYSLIGCRLACESR 321

  Fly   426 YTVSKCGCAKFWMPKPLGTPVCG---LKDINCYTSAQDELYTLMQNQTMAKSIDES--------- 478
            |...||||....||.  .:|||.   .||  |.:.|..:.:.......:...||.:
Mouse   322 YVARKCGCRMMHMPG--NSPVCSPQQYKD--CASPALGKAHLFSLPVPIHSDIDHNPLGQVLLFL 382

  Fly   479 ----VDI-----TCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDAIGSR----LSVYF 530
                .|.     ||.|...|.:..|..|:|..:.....:.|....:|..::...:.    |.::|
Mouse   383 ALRPADAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSETYITENVLVLDIFF 447

  Fly   531 KEHQFTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELIYFFCM----RICGSCRDRRKHKI 591
            :...:.|:::...:.||.|:.:.||..|||:|.|.|:.||::.:.|.    |:.|...:||..:.
Mouse   448 EALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSSQR 512

  Fly   592 QQQNSVDLPEE 602
            :..|:: |.||
Mouse   513 RSGNTL-LQEE 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:459966	116/562 (21%)
Asic3	XP_006535700.1	ENaC	21..546	CDD:273304	125/596 (21%)