Protein Alignment ppk and Asic1

DIOPT Version :10

• Sequence 1: NP_477232.1
• Gene: ppk / 34843
• FlyBaseID: FBgn0020258
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 669
• Identity: 135/669 - (20%)
• Similarity: 218/669 - (32%)
• Gaps: 253/669 - (37%)

  Fly     6 EDEEEKKSGISILPGPELLALPGFDTRASIASAALSDVPSDVIIKSRIRYGSPLSACKGLLLEYA 70
            |:|:||:||:.:..|                     |.|.|                   |:.:|
Mouse    43 EEEKEKESGMELDEG---------------------DSPRD-------------------LVAFA 67

  Fly    71 KSTTIHGIRYIFEVHRPIYEKLYWLFFTCISVYFAVSL------IWDTYLKWQESPVILGFDETL 129
            .|.|:||..::|....|...:..|      :|.|.::|      :.|....:...|.:...||
Mouse    68 NSCTLHGASHVFVEGGPGPRQALW------AVAFVIALGAFLCQVGDRVAYYLSYPHVTLLDE-- 124

  Fly   130 VPVHKIPFPTITICPEIKMERNVFDYTNVSRQLWEEYKQNGNISDLDDEDLARMAVAMHICDSEV 194
            |...::.||.:|.|           .||..|           :|.|...||..:|..:.:.:|:
Mouse   125 VATTELVFPAVTFC-----------NTNAVR-----------LSQLSYPDLLYLAPMLGLDESD- 166

  Fly   195 VQRFTPLLSQLNPPNVDVTQTLIDLSISKNETGPFCKWNG------RFY--FCDKI--------- 242
             ....||.    ||                  ||.. ::|      |||  .|.::
Mouse   167 -DPGVPLA----PP------------------GPEA-FSGEPFNLHRFYNRSCHRLEDMLLYCSY 207

  Fly   243 ---------FDFVATDEGICYQFNGLRPKDIYRDEKFISYVDPDVVDFNKYFDVDLPPWNNITGN 298
                     |..|.|..|.||.||
Mouse   208 CGGPCGPHNFSVVFTRYGKCYTFN----------------------------------------- 231

  Fly   299 WSLDTGFVDQGQNAYPQ-RTVFSSVKNGFFAFLQGLQHNF-----DYDCRSFKQGYKVFLNSPES 357
                     .||:..|: :|:.....||....|...|..:     :.|..||:.|.||.::|.:.
Mouse   232 ---------SGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDE 287

  Fly   358 VPLTTGNYILVPHGDEVLVSVLPAYVVSTDNLHEITPEKRQCLF-------------DDERSLRF 409
            .|..          |::...|.|.:...      ::.::::.::             |.:    |
Mouse   288 PPFI----------DQLGFGVAPGFQTF------VSCQEQRLIYLPSPWGTCNAVTMDSD----F 332

  Fly   410 FRSYSQSNCQTECLANYTVSKCGCAKFWMPKPLGTPVCGLKDI-NCYTSAQDELYTLMQNQTMAK 473
            |.|||.:.|:.:|...|.|..|.|....||.  ..|.|..:.. .|...|.|.|....|..
Mouse   333 FDSYSITACRIDCETRYLVENCNCRMVHMPG--DAPYCTPEQYKECADPALDFLVEKDQEY---- 391

  Fly   474 SIDESVDITCNCMPACTSLEYNFEISRAKYDVAKTIRAFREEYEHTDA-IGSR---LSVYFKEHQ 534
                     |.|...|....|..|:|..|.....:.:...:::..::. ||..   |.::|:...
Mouse   392 ---------CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLN 447

  Fly   535 FTAIKRTILFGVSTLISNCGGICGLFMGISCLSFLELI-YFFCM---RIC--GSCRDRRKHKIQQ 593
            :..|::...:.::.|:.:.||..|||:|.|.|:.|||. |.:.:   |:|  |.|:...|
Mouse   448 YETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAK----- 507

  Fly   594 QNSVD------LPEEKSEN 606
            :||.|      |.:.|..|
Mouse   508 RNSADKGVALSLDDVKRHN 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk	NP_477232.1	ASC	69..574	CDD:459966	112/561 (20%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	125/609 (21%)