Protein Alignment spel1 and MSH5

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_010127.1
• Gene: MSH5 / 851401
• SGDID: S000002313
• Length: 901
• Species: Saccharomyces cerevisiae
• Alignment Length: 955
• Identity: 218/955 - (22%)
• Similarity: 393/955 - (41%)
• Gaps: 227/955 - (23%)

  Fly    23 NFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSM 87
            :.:.:|.|       |::.||..               .:|.|:|.....|:.|        ..|
Yeast    73 SILDYHTK-------TLKAFDQD---------------YVVNKTTISSHDLIDD--------ADM 107

  Fly    88 SKGNFELAVRELLLVRNYRVEVYVKNSSDW----------EIEYRGSPGNLLQFE--DILFSNKE 140
            |..:..|.:..|::..|..|.:......||          ||..|.....:.:|:  |:|.|
Yeast   108 SSNDISLLLGLLIMEANPTVCLVPARLEDWIFDYIKTKCDEINCRLELQPIKRFKKWDLLQS--- 169

  Fly   141 VLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSI 205
                       ::|.|             :|.:..|.:.|.:..||    |.|.||...|:|.:.
Yeast   170 -----------LQLRG-------------HDNQTILNDILSNSKFT----TTVTLGTVGCILANH 206

  Fly   206 E--GEYSAVKTLLDRNGVMITMPKKSGDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASNALK 268
            |  |||                      ||.....|.:           ||      :|..||.:
Yeast   207 EQLGEY----------------------NDSTASSNMV-----------TG------RLVQNAFE 232

  Fly   269 TAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMP---KPGTHPSMPSYRWQSVLGV 330
            ..|              :.|:.:|:...:.||...::||:|.|   |.| |..|....:.||..:
Yeast   233 DVI--------------HGIRYIDIRDRMVLDENTISALHIFPTAHKLG-HDKMMRNGFFSVFEL 282

  Fly   331 LDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDY-LKRIPDILMLTKK 394
            .:...:....|::..|:..||.::..:..|::|::.||:..:.:....|.. :||.||......:
Yeast   283 FNQVSSDYARRILKSWLINPLTNKKRIETRYSIIRTLLDKQNAIIFSDLSQSIKRCPDAFGFINQ 347

  Fly   395 LMRRKANLQDLFRIYQVILRTPKILKVLHELDNSTIESVICAPFKSFLKDLTGLKQ---MVEQVV 456
            |...|:.|....::...:.:...|.:::..|...:.|:.|....|:.: |::.||:   .||.|:
Yeast   348 LRSGKSTLGTWSKVASFLEKGIAIFQLVSSLKLGSDEANILHDIKNKV-DISALKECLRKVETVI 411

  Fly   457 DFEAIERGEYL-VKASFDSRLMELQQMMTELYSKMEELQFKCSQELNL---------DGKNQVKL 511
            ||:.....:.| :....|:||.|.:    .:|:.:|.:....::|..:         |.|....|
Yeast   412 DFDTSRDTKTLTINTGVDNRLDECR----NIYNHLEGILLDVARETQIFLLNTMPQEDCKTTKSL 472

  Fly   512 ES------VAKLGHHFRITVKDDSVLRKNKNYRIVDVIKG--GVRFTSDKL----EGYADEFASC 564
            |.      :.:||:...|:|..:.:|....|.:..::.:.  .:.|.:.::    |.|.|.:.:.
Yeast   473 EKLVNAVYIPQLGYLVTISVLMEPLLDGIPNLQWEEIFRSSENIYFKNGRVLELDETYGDIYGAI 537

  Fly   565 RTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARE 629
            .....|...|:.|:|:.    ....||..|..|::|:.|:|||..  ||...|..|:::|:   |
Yeast   538 SDFEIEILFSLQEQILR----RKTQLTAYNILLSELEILLSFAQV--SAERNYAEPQLVED---E 593

  Fly   630 LVLEDV--RHPCLE--LQEHVNFIANS--VD---------FKKEECNMFIITGPNMGGKSTYIRS 679
            .:||.:  ||...|  |.   |:|.||  :|         .::.:..:.::||.|..|||.|:..
Yeast   594 CILEIINGRHALYETFLD---NYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGANASGKSVYLTQ 655

  Fly   680 VGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVI 744
            .|..|.:|.||.|||...|.|.:.|.||.|:...:.:.|..|:|:::..:.:..:..||:|||::
Yeast   656 NGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQMAKSLSLATEKSLIL 720

  Fly   745 IDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFA-THFHEI---TKLAETLSTVKN-------- 797
            |||.|:||...:|..:..||..:::|..||..:.| |||||:   ..|.|.:..:|:
Yeast   721 IDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNENVLTENIKGIKHYCTDILIS 785

  Fly   798 --------CHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQE---VYNEFED 851
                    .|:....:::..|.|::|:.|:.::||||..|::......:|:.|:|   :.|..:|
Yeast   786 QKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCAKVCGLSRDIVERAEELSRMINRGDD 850

  Fly   852 ------EHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLT 890
                  ...:|:.:|    .:|.|..:::..    :.|:::|..|
Yeast   851 VVQQCGNLTEKEMRE----FQKNQEIVKKFL----SWDLDLETTT 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350	21/117 (18%)
		MutS	174..890	CDD:440019	189/790 (24%)
MSH5	NP_010127.1	mutS1	<224..897	CDD:273427	172/710 (24%)
		ABC_MSH5_euk	597..830	CDD:213248	70/235 (30%)