Protein Alignment spel1 and msh3

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_009300056.1
• Gene: msh3 / 565400
• ZFINID: ZDB-GENE-060526-307
• Length: 1087
• Species: Danio rerio
• Alignment Length: 982
• Identity: 265/982 - (26%)
• Similarity: 416/982 - (42%)
• Gaps: 228/982 - (23%)

  Fly     3 AKATDSR---QEPTLNMDTNARRNFI-----KFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELV 59
            ||.|.:|   :||::   :|.|...|     :.:.::.::...||...:...:|...| :|.|:.
Zfish   165 AKNTGNRKSLEEPSV---SNRRTKTIYTPLEEQYMEIKKQHVDTVLCVECGYKYRFFG-EDAEIA 225

  Fly    60 AK----IVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSSDWEIE 120
            ||    ..:....|:.|.:|..:    .||.:.:          |:.:.|:|.| ||.:....|
Zfish   226 AKELNITCHLDHNFMTASIPTHR----LFVHVRR----------LVSQGYKVGV-VKQTETTAI- 274

  Fly   121 YRGSPGNLLQFEDILFS-------NKEVLVGNSIISLL----------VKLDGGG---------- 158
             :.|..|    :..|||       .|..|||..:..||          |..|.|.
Zfish   275 -KASSAN----KSSLFSRQLHALYTKSTLVGEDVNPLLKLGDLEQAEDVVQDSGNNYLMCVSESF 334

  Fly   159 -----QRRVGVASVEQN------DCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIEGEYSAV 212
                 :..||:..|:.:      ||      |.|:...:|||:.::.:.|.|.|:||   :.|..
Zfish   335 DKQSKELTVGMVVVQPSIGDVMVDC------FKDNMSHSELESRILRIQPVEILVPS---DLSET 390

  Fly   213 KTLLDRNGVMITMPKKSGDNDLLQD------------LNRLLRFAKGQQEDAT-----GLKELQL 260
            ...|.||   |.:.....|:.:..:            |:.:..|.:|....|.     |...:.:
Zfish   391 TERLLRN---IALSSVQADDRIRIEKRESAMFEYPTALSIIKDFYRGGPHSAARNHEKGSYSICM 452

  Fly   261 QLASN---ALKTAIKYLDLVNDAGNLGHYEIKQLDL--NRFVHLDS---------AAVAALNIMP 311
            .|.|.   .|...|:||.         .::::::.|  :.|..|.|         |.:..|.|:.
Zfish   453 GLESPIICCLGPVIQYLT---------EFKLEKILLCSSSFKRLSSDPDHMLLSAATMKNLEILC 508

  Fly   312 KPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMET 376
            ...|.....|..|     ||||.:|..|.||:.:||.|||:|...:..|...|..:|.|..::..
Zfish   509 NQTTGSVKGSLLW-----VLDHTQTLFGKRLLRKWVSQPLKSVIDIQARQEAVAEILSSESSVLP 568

  Fly   377 LSLDYLKRIPDI-----------------LMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHE 424
            .....|.|:||:                 .::...|.|....||.|....|..|.:| :||.| .
Zfish   569 SIQSLLTRLPDLERGLCSIYHKRCSTQEFYLIISSLSRLNVELQALMPAIQSQLSSP-LLKTL-L 631

  Fly   425 LDNSTIESVICAPFKSFLKDL------TGLK-QMVEQVVDFEAIERGEYLVKASFDSRLMELQQM 482
            ||...:.|    |..:|||.|      ||.| :|...:.||..|.:    .|...:|.|:::.:.
Zfish   632 LDTPQLLS----PAHNFLKVLNEKAAKTGNKTEMFVDLTDFPVIRK----TKEEIESVLLDIMEH 688

  Fly   483 MTE--LYSKMEELQFK--CSQELNLDGKNQ---------VKLESVAKLG-HHFRITVKDDSVLRK 533
            ..|  |..|...|.:.  ..|:..::.||.         ||:.|....| :|....|:....|::
Zfish   689 RREVRLLLKNPSLDYTTVSGQQFLIEVKNSMLSIVPADWVKISSTKVFGRYHTPFIVEKHRRLQQ 753

  Fly   534 NKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELA 598
            .:...::|.....:.|    |:.:.|.:...|           :.:.|               ||
Zfish   754 LREQLVIDCNHEWINF----LQLFGDHYYILR-----------KAVCH---------------LA 788

  Fly   599 QLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLE--LQEHVNFIANSVDFKKEECN 661
            .:|||.|.|..|:.  ..|.||::|||.::.|:... :||.:.  :.:...::.|....:.:...
Zfish   789 TMDCLFSLAQVAKE--NNYCRPEVLEEKSQILITAG-KHPVITSLMGDQDQYVPNDTHLQGDGKR 850

  Fly   662 MFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVE 726
            ..|||||||||||:|||.|....:||.:|:|||...|::.:||.|..|:||||||.:|.||||.|
Zfish   851 AMIITGPNMGGKSSYIRQVALVTIMAQLGSFVPAREASVGIVDGIYVRMGASDNISRGRSTFMEE 915

  Fly   727 MIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAET 791
            ::|||.::..||.:||||:|||||||||::|..||::..|...:|.:|.|||.||:..:.:|...
Zfish   916 LLETSDVLACATSRSLVILDELGRGTSTHDGIAIAYATLESFIREVRCMTLFVTHYPPLCELEHL 980

  Fly   792 L-STVKNCHMA-------AVADADD-----FTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQ 843
            . ..|.|.|||       :.:|.::     .|.|||:..|...:|:|:.|||||..||.:::.|.
Zfish   981 YPQHVGNYHMAFLLNEPESTSDEEEAQPEFITFLYQLIEGAAARSYGLNVARLAEIPESILRTAA 1045

  Fly   844 EVYNEFE 850
            ....|.|
Zfish  1046 FKSKELE 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350	23/116 (20%)
		MutS	174..890	CDD:440019	217/761 (29%)
msh3	XP_009300056.1	MutS	188..1053	CDD:440019	256/956 (27%)