Protein Alignment spel1 and Msh4

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_114076.2
• Gene: Msh4 / 55993
• MGIID: 1860077
• Length: 911
• Species: Mus musculus
• Alignment Length: 846
• Identity: 212/846 - (25%)
• Similarity: 365/846 - (43%)
• Gaps: 175/846 - (20%)

  Fly   146 SIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPS---IEG 207
            |:|..:|:..|..:..:|:||::....:..|.:|.|:..:.::...:.:|.|.|.::.:   :.|
Mouse   130 SVIVAVVEGRGLARGEIGMASIDLKSPQIMLSQFADNTTYAKVITKLQVLSPLEIIMSNTACVVG 194

  Fly   208 EYSAVKTLLDRN--GVMITMPKKSGDNDLLQDLNRLLRFAKGQQ--------EDATGLKELQLQL 262
            ..:.:.||:..|  .|..|..::...|:           .||.:        |.::.|.|:|.:.
Mouse   195 NSTKLFTLITENFKNVNFTTVQRKYFNE-----------TKGLEYIEQLCIAEFSSVLMEVQSRY 248

  Fly   263 ASNALKTA-IKYLDLVNDAGNLGHYEIKQLDL-----NRFVHLDSAAVAALNIMPKPGTHPSMPS 321
            ...|...| :||::.:.::    .|..|.|.:     .:...:||::...|.::      .:...
Mouse   249 YCLAAAAALLKYVEFIQNS----VYAPKSLKIYFQGSEQTAMIDSSSAQNLELL------VNNQD 303

  Fly   322 YRWQSVL-GVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESP-------------- 371
            ||....| |||::.:|..|.|.:...:.:||.....::.|.:.||.||:..
Mouse   304 YRSNHTLFGVLNYTKTAGGSRRLRSNILEPLVDVETISMRLDCVQELLQDEELFFGLQSVISRFL 368

  Fly   372 DTMETLS--------------------LDYLKRIPDI---LMLTKK-----LMRR-KANLQD--- 404
            ||.:.||                    |.|||...::   |.:|.|     |:|. ..:|:|
Mouse   369 DTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVEPLKVTLKNCSTPLLRAYYGSLEDHRF 433

  Fly   405 ---LFRIYQVI------------LRTPKILKVLHELDNSTIESVICAPFKSFLKDLTGLKQMVEQ 454
               |.:|..||            :||.|...|...:  |....:....:...:.|:.|   |:.|
Mouse   434 GLILDKIKTVINDDARYMKGCLNMRTQKCYAVRSNI--SEFLDIARRTYTEIVDDIAG---MIAQ 493

  Fly   455 VVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGH 519
            :.     |:....::.||.|......||.|:           |: .|:.|   |:..|.: |:
Mouse   494 LA-----EKYSLPLRTSFSSSRGFFIQMTTD-----------CA-ALSSD---QLPSEFI-KI-- 535

  Fly   520 HFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEF-ASCRTRYEEQQLSIVEEIIHVA 583
                     |.::.:.::...|:||...|......|.|...: ..|:.      ||.:.|.||.
Mouse   536 ---------SKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKL------LSEIYEHIHC- 584

  Fly   584 VGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLELQEHVNF 648
                  |..|::.::.||.|:|||.|.  ..:.||||:..:    .|.::...||.||.......
Mouse   585 ------LYKLSDTVSMLDMLLSFAHAC--TLSDYVRPEFTD----TLAIKQGWHPILEKISAEKP 637

  Fly   649 IANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGAS 713
            :||:. :..|..|:.|||||||.|||||::.:....:||.||::||...|:..:...|..|:...
Mouse   638 VANNT-YITEGSNVLIITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYASFRIAAQIFTRISTD 701

  Fly   714 DNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLF 778
            |:|....||||.||.|.:.|:..|.||||::||||||||:|.||.||::::.|||. ..|.||||
Mouse   702 DDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGISYAVCEHLL-SIKAFTLF 765

  Fly   779 ATHFHEITKLAETLSTVKNCHMA------AVADADDFTLLYQVRSGVM-EKSFGIQVARLANFPE 836
            .|||.|:..|......|:|.|..      ...:.|.....|::..|:. ||::|::.|..::.|.
Mouse   766 TTHFLELCHLDALYLNVENMHFEVQHVKNTSRNKDAILYTYKLSRGLTEEKNYGLKAAEASSLPS 830

  Fly   837 HVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLST----AGNNVDINVEDLTQLVTQFT 897
            .:|.:|:::..:...:.:..|:...:  ::: |.|:..|:|    |..|..:..:.|...::...
Mouse   831 SIVLDARDITTQITRQILQNQRSSPE--MDR-QRAVYHLATRLVQAARNSQLEPDRLRTYLSNLK 892

  Fly   898 K 898
            |
Mouse   893 K 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350
		MutS	174..890	CDD:440019	203/808 (25%)
Msh4	NP_114076.2	MutS	132..839	CDD:440019	202/785 (26%)