Protein Alignment spel1 and MSH5

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_751897.1
• Gene: MSH5 / 4439
• HGNCID: 7328
• Length: 835
• Species: Homo sapiens
• Alignment Length: 826
• Identity: 214/826 - (25%)
• Similarity: 359/826 - (43%)
• Gaps: 174/826 - (21%)

  Fly   153 KLDGGGQRRVG-VASVEQNDCKFQLLEFLDD-DFFTELEATVVLLGPKECLLPSIEGEYSAVKTL 215
            |.|....|.:| :||.|..:.|...:.||.. ||..|:.        |:.||   .|.||.:...
Human   105 KQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEIS--------KQRLL---SGNYSFIPDA 158

  Fly   216 LDRNGVMITMPKKSGDNDLL--QDLNRLLRFAKGQQEDATGLKELQLQLASNALKTAIKYLDLVN 278
            :.....::.:......:.||  :.|..||:|        .|.:.:.::|....:...|
Human   159 MTATEKILFLSSIIPFDCLLTVRALGGLLKF--------LGRRRIGVELEDYNVSVPI------- 208

  Fly   279 DAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYR-------WQSVLGVLDHCRT 336
                ||   .|:..|...|::|....:.|.|. |..:|||:  |:       ..|:.|:|:.|..
Human   209 ----LG---FKKFMLTHLVNIDQDTYSVLQIF-KSESHPSV--YKVASGLKEGLSLFGILNRCHC 263

  Fly   337 PQGHRLMGQWVKQPLRSRNILNDRHNIVQCLL--ESPDTMETLS--LDYLKRIPDILMLTKKLMR 397
            ..|.:|:..|..:|......|:.|.:::|..|  ::.|..:.|.  |.::|.:|.||...|....
Human   264 KWGEKLLRLWFTRPTHDLGELSSRLDVIQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHT 328

  Fly   398 RKANLQDLFR-IYQVI-LR-----TPKILKVLHELDNSTIESVICAPFKSFLKDLTGLKQMVEQV 455
            :.::.|.|:: :|..: ||     .|:.:::..::            .:.|..||..:..::.:|
Human   329 KVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDI------------AQEFSDDLHHIASLIGKV 381

  Fly   456 VDFE-AIERGEYLVKASFD-------SRLMELQQMMTELYSKMEELQFKCSQELNLDGK------ 506
            |||| ::....:.|..:.|       .|||.|...:||:..|  ||:       |||.:
Human   382 VDFEGSLAENRFTVLPNIDPEIDEKKRRLMGLPSFLTEVARK--ELE-------NLDSRIPSCSV 437

  Fly   507 ----------NQVKLESVAKLGHHFRITVKDDSVLRKNK-NYRI-----VDVIKGGVRFTSDKLE 555
                      :..:|.|:.: ...|.|...|...|.:.| :||.     :|.:.|.:.
Human   438 IYIPLIGFLLSIPRLPSMVE-ASDFEINGLDFMFLSEEKLHYRSARTKELDALLGDLH------- 494

  Fly   556 GYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRP 620
                    |..|  :|:..::.::....:..||.||.:.:..::||.|::.|.|||.  ..|.||
Human   495 --------CEIR--DQETLLMYQLQCQVLARAAVLTRVLDLASRLDVLLALASAARD--YGYSRP 547

  Fly   621 KMLEE--GARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTA 683
            :...:  |.|   :::.|||.:||... .|:.||.:...::..:.:|||||..|||.|::.||..
Human   548 RYSPQVLGVR---IQNGRHPLMELCAR-TFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLI 608

  Fly   684 VLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEM-IETSGIIRTATDKSLVIIDE 747
            ..||.:|:|||...|.|..||:|..|:.:.::|..||||||::: .:.:..:..||.:|||:|||
Human   609 TFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAVNNATAQSLVLIDE 673

  Fly   748 LGRGTSTYEGCGIAWSIAEH-LAKETKCFTLF-ATHFHEITK--------LAETLSTVKNCHMAA 802
            .|:||:|.:|..:..::..| ||:...|..:| ||:|..:.:        |.:.| |::.|.
Human   674 FGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQLQLLPQGPLVQYL-TMETCE--- 734

  Fly   803 VADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEK 867
              |.:|....|||..||.:.|.....|..|..|:.:|...:||.:....   .|..|..|.||:|
Human   735 --DGNDLVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRS---GKPIKPVKDLLKK 794

  Fly   868 IQVAIQQLSTAGNNVDINVEDLTQLVTQFTK-DIE--QLDSDYFKS 910
            .|                :|:...||.:|.| |:|  .||.:.|.|
Human   795 NQ----------------MENCQTLVDKFMKLDLEDPNLDLNVFMS 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350
		MutS	174..890	CDD:440019	196/779 (25%)
MSH5	NP_751897.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		mutS1	<245..774	CDD:273427	153/579 (26%)
		ABC_MSH5_euk	557..764	CDD:213248	74/216 (34%)