Protein Alignment spel1 and MSH4

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_002431.2
• Gene: MSH4 / 4438
• HGNCID: 7327
• Length: 936
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 214/840 - (25%)
• Similarity: 367/840 - (43%)
• Gaps: 152/840 - (18%)

  Fly   146 SIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIE---G 207
            |:|..:|:..|..:..:|:||::..:.:..|.:|.|:..:.::...:.:|.|.|.::.:..   |
Human   155 SVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTACAVG 219

  Fly   208 EYSAVKTLLDRN--GVMITMPKKSGDNDLLQDLNRLLRFAKGQQ--------EDATGLKELQLQ- 261
            ..:.:.||:..|  .|..|..::...|:           .||.:        |.:|.|.|:|.:
Human   220 NSTKLFTLITENFKNVNFTTIQRKYFNE-----------TKGLEYIEQLCIAEFSTVLMEVQSKY 273

  Fly   262 --LASNALKTAIKYLDLVNDAGNLGHYEIKQLDL-----NRFVHLDSAAVAALNIMPKPGTHPSM 319
              ||  |:...:||::.:.::    .|..|.|.:     .:...:||::...|.::      .:.
Human   274 YCLA--AVAALLKYVEFIQNS----VYAPKSLKICFQGSEQTAMIDSSSAQNLELL------INN 326

  Fly   320 PSYRWQSVL-GVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESP------------ 371
            ..||....| |||::.:||.|.|.:...:.:||.....:|.|.:.||.||:..
Human   327 QDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINMRLDCVQELLQDEELFFGLQSVISR 391

  Fly   372 --DTMETLSLDYLKRIP--DILMLTKK------LMRRKANLQDLFRIYQVILRTPKILKVLHELD 426
              ||.:.||:  |.:||  |.:...:.      .::....|.|..:|......||.:......|:
Human   392 FLDTEQLLSV--LVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKIAMKNCNTPLLRAYYGSLE 454

  Fly   427 NSTIESVICAPFKSFLKD----LTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELY 487
            :... .:|....|:.:.|    :.|...|..|..         |.|:::.:..|...::..||:
Human   455 DKRF-GIILEKIKTVINDDARYMKGCLNMRTQKC---------YAVRSNINEFLDIARRTYTEI- 508

  Fly   488 SKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSV-------------LRKNKN--- 536
              ::::....||   |..|..:.|.:.......|.|.:..|.:             :.|.||
Human   509 --VDDIAGMISQ---LGEKYSLPLRTSFSSARGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYS 568

  Fly   537 YRIVDVIKGGVRFTSDKLEGYADEF-ASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQL 600
            :...|:||...|......|.|...: ..|:.      ||.:.|.||.       |..|::.::.|
Human   569 FTSADLIKMNERCQESLREIYHMTYMIVCKL------LSEIYEHIHC-------LYKLSDTVSML 620

  Fly   601 DCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMFII 665
            |.|:|||.|.  ..:.||||:..:    .|.::...||.||.......|||:. :..|..|..||
Human   621 DMLLSFAHAC--TLSDYVRPEFTD----TLAIKQGWHPILEKISAEKPIANNT-YVTEGSNFLII 678

  Fly   666 TGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIET 730
            |||||.|||||::.:....:||.||::||...::..:...|..|:...|:|....||||.||.|.
Human   679 TGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEI 743

  Fly   731 SGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTV 795
            :.|:..|.||||::||||||||:|.||.||.:::.|:|. ..|.||||||||.|:..:......|
Human   744 AYILHNANDKSLILIDELGRGTNTEEGIGICYAVCEYLL-SLKAFTLFATHFLELCHIDALYPNV 807

  Fly   796 KNCHMA------AVADADDFTLLYQVRSGVM-EKSFGIQVARLANFPEHVVQNAQEVYNEFEDEH 853
            :|.|..      ...:.:.....|::..|:. ||::|::.|.:::.|..:|.:|:|:..:...:.
Human   808 ENMHFEVQHVKNTSRNKEAILYTYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQI 872

  Fly   854 VDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIEQLDSDYFKSVLA 913
            :..|:...:  :|: |.|:..|:             |:||.  |....|||.|..:..|:
Human   873 LQNQRSTPE--MER-QRAVYHLA-------------TRLVQ--TARNSQLDPDSLRIYLS 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350
		MutS	174..890	CDD:440019	198/787 (25%)
MSH4	NP_002431.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..133
		MutS	157..864	CDD:440019	198/768 (26%)