Protein Alignment spel1 and MSH3

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_002430.3
• Gene: MSH3 / 4437
• HGNCID: 7326
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 971
• Identity: 252/971 - (25%)
• Similarity: 412/971 - (42%)
• Gaps: 192/971 - (19%)

  Fly     1 MQAKATDSRQEPTLNMDTNARRNFIKFHAKLGEKPAT-------TVRFFDHTDRYTVHGSDDCEL 58
            :|..|:.|..:.:.::.|.....:|:.  |...|.|.       ..|||          .:|.|:
Human   213 LQKTASKSANKRSKSIYTPLELQYIEM--KQQHKDAVLCVECGYKYRFF----------GEDAEI 265

  Fly    59 VAK----IVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSSDWEI 119
            .|:    ..:....|:.|.:|..:    .||.:.:          |:.:.|:|.| ||.:....:
Human   266 AARELNIYCHLDHNFMTASIPTHR----LFVHVRR----------LVAKGYKVGV-VKQTETAAL 315

  Fly   120 EYRGSPGNLLQFEDILFS-------NKEVLVGNSIISLLVKLDGG-------------------- 157
            :..|..      ...|||       .|..|:|.. ::.|:|||..
Human   316 KAIGDN------RSSLFSRKLTALYTKSTLIGED-VNPLIKLDDAVNVDEIMTDTSTSYLLCISE 373

  Fly   158 ----------GQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIEGEY--- 209
                      |...:|:..|:....:.....|.|....:|||..:..|.|.|.||||...|.
Human   374 NKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEA 438

  Fly   210 -----SAVKTLLDRNGVMITMPKKSGDNDLLQDLNRLLRFAKGQQEDATGLKELQL--------Q 261
                 ::|....||..|      :..||...:..:......:...:|...:|..|:        :
Human   439 LIHRATSVSVQDDRIRV------ERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEK 497

  Fly   262 LASNALKTAIKYLDLVNDAGNLGHYE-IKQLDLN-RFVHLDSAAVAALNIMPKPGTHPSMPSYRW 324
            ....:|...||||...|....|...| .|||... .|:.::...:..|.|:.......:..|..|
Human   498 PVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLW 562

  Fly   325 QSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDIL 389
                 ||||.:|..|.|.:.:||.|||.....:|.|.:.|..:|.|..::.....::|:::|||.
Human   563 -----VLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIE 622

  Fly   390 MLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDNSTIES-----------VICAPFKSFLK 443
            .....:..:|.:.|:.|.|.:.:.......:.:....||.|:|           .:.:|.:.:||
Human   623 RGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLK 687

  Fly   444 DL------TGLK-QMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQEL 501
            .|      .|.| ::.:.:.||..|::.:..::...|...|.||::...|.:...:......||.
Human   688 ILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEF 752

  Fly   502 NLDGKNQ---------VKLESVAKLGH-HFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEG 556
            .::.||.         ||:.|...:.. |....|::...|.:.:...::|.....:.|    ||.
Human   753 MIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDF----LEK 813

  Fly   557 YADEFAS-CRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRP 620
            :::.:.| |:.             :|              .||.:||:.|.|..|:..  .|.||
Human   814 FSEHYHSLCKA-------------VH--------------HLATVDCIFSLAKVAKQG--DYCRP 849

  Fly   621 KMLEEGARELVLEDVRHPCLE--LQEHVNFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTA 683
            .:.||  |::|:::.|||.::  |.|...::.|:.|..::...:.|||||||||||:||:.|...
Human   850 TVQEE--RKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALI 912

  Fly   684 VLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDEL 748
            .:||.||::||...|||.:||.|..|:||:|||.||.||||.|:.:|:.|||.||.:||||:|||
Human   913 TIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDEL 977

  Fly   749 GRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLS-TVKNCHMAAVADAD----- 807
            ||||||::|..||::..|:..::.|..|||.||:..:.:|.:..| .|.|.||..:...|
Human   978 GRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLD 1042

  Fly   808 --------DF-TLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKK 859
                    || |.|||:..|:..:|:|:.||:||:.|..:::.|.....|.|.....|:|:
Human  1043 PGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKR 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350	22/118 (19%)
		MutS	174..890	CDD:440019	213/750 (28%)
MSH3	NP_002430.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..122
		Interaction with EXO1. /evidence=ECO:0000269|PubMed:11427529	75..297		19/109 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..222		3/8 (38%)
		MutS	225..1094	CDD:440019	246/948 (26%)