Protein Alignment spel1 and MSH6

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001393724.1
• Gene: MSH6 / 2956
• HGNCID: 7329
• Length: 1392
• Species: Homo sapiens
• Alignment Length: 940
• Identity: 233/940 - (24%)
• Similarity: 382/940 - (40%)
• Gaps: 238/940 - (25%)

  Fly   101 LVRNYRVEVYVKNSSDWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVA 165
            :||.....:..|.:..:.: ..|.|..  .:...|.|.||....:|          |..|..||.
Human   540 VVRREICRIITKGTQTYSV-LEGDPSE--NYSKYLLSLKEKEEDSS----------GHTRAYGVC 591

  Fly   166 SVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIEGEYS-AVKTLL------------- 216
            .|:.:..||.:.:|.||...:.....|....|.:.|..  :|..| ..||:|
Human   592 FVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFE--KGNLSKETKTILKSSLSCSLQEGLI 654

  Fly   217 ------DRNGVMITMPKKSGDNDLLQD-----LNRLLRFAKG--QQEDATGLKE-LQLQLASNAL 267
                  |.:..:.|:.::....:.|.|     |.::|   ||  .:.|:.||.. .:.:||.:||
Human   655 PGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVL---KGMTSESDSIGLTPGEKSELALSAL 716

  Fly   268 KTAIKYLD---LVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALN---IMPKP------------- 313
            ...:.||.   :..:..::.::|       .::.|||..|:...   |..|.
Human   717 GGCVFYLKKCLIDQELLSMANFE-------EYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNN 774

  Fly   314 ------GTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPD 372
                  ||:.|...    ::|..:|.|.||.|.||:.||:..||.:...:|||.:.::.|:..||
Human   775 LEIFLNGTNGSTEG----TLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPD 835

  Fly   373 TMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDNSTIESVICAP 437
            .:..: ::.||::||:..|..|:....:.|:.        ...|....:::|....:.:.:|
Human   836 KISEV-VELLKKLPDLERLLSKIHNVGSPLKS--------QNHPDSRAIMYEETTYSKKKII--- 888

  Fly   438 FKSFLKDLTGLKQM------VEQVVD-----------------------------------FE-- 459
              .||..|.|.|.|      :|:|.|                                   |:
Human   889 --DFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFDHE 951

  Fly   460 -AIERGEYLVKASFDS-------RLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAK 516
             |.:.|....||.|||       .:.|.:|.:.|...|.               :|::...::..
Human   952 KARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQ---------------RNRIGCRTIVY 1001

  Fly   517 LG---HHFRITVKDDSVLRK-NKNYRIVDVIKGGVRFTSDKLEG------YADE-----FASCRT 566
            .|   :.:::.:.::...|. .:.|.:....||..|:.:..:|.      .|:|     ...|..
Human  1002 WGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDVSLKDCMR 1066

  Fly   567 R--------YEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKML 623
            |        |::.| |.||.|                  |.||.|:..|..:|....|..||.:|
Human  1067 RLFYNFDKNYKDWQ-SAVECI------------------AVLDVLLCLANYSRGGDGPMCRPVIL 1112

  Fly   624 --EEGARELVLEDVRHPCL-ELQEHVNFIANSVDFKKEE---------CNMFIITGPNMGGKSTY 676
              |:....|.|:..||||: :.....:||.|.:....||         |  .::||||||||||.
Human  1113 LPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYC--VLVTGPNMGGKSTL 1175

  Fly   677 IRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKS 741
            :|..|...:||.:|.:||..:..::.:|.:..|:||||.|:.|.|||.||:.||:.|:..||..|
Human  1176 MRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVELSETASILMHATAHS 1240

  Fly   742 LVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVAD- 805
            ||::|||||||:|::|..||.::.:.||:..||.|||:||:|.:.:.......|:..|||.:.:
Human  1241 LVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVEN 1305

  Fly   806 ------ADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKAL 864
                  .:..|.||:...|...||:|...|||||.||.|:|.......|||        |.:::|
Human  1306 ECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFE--------KMNQSL 1362

  Fly   865 LEKIQVAIQQLSTAGNNVDINVEDLTQLVT 894
            .     ..:::..|.....::.|.:.:|:|
Human  1363 R-----LFREVCLASERSTVDAEAVHKLLT 1387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350	5/30 (17%)
		MutS	174..890	CDD:440019	215/861 (25%)
MSH6	NP_001393724.1	PWWP_MSH6	122..225	CDD:438962
		MutS	439..1392	CDD:440019	233/940 (25%)