Protein Alignment spel1 and Msh4

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001099947.2
• Gene: Msh4 / 295541
• RGDID: 1309190
• Length: 911
• Species: Rattus norvegicus
• Alignment Length: 835
• Identity: 205/835 - (24%)
• Similarity: 355/835 - (42%)
• Gaps: 147/835 - (17%)

  Fly   146 SIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPS---IEG 207
            |:|..:|:..|..:..:|:||::....:..|.:|.|:..:.::...:.:|.|.|.::.:   :.|
  Rat   130 SVIVAVVEGRGLARGEIGMASIDLKSPQIMLSQFADNTTYAKVITKLQVLSPLEIIMSNTACVVG 194

  Fly   208 EYSAVKTLLDRN--GVMITMPKKSGDNDLLQDLNRLLRFAKGQQ--------EDATGLKELQLQL 262
            ..:.:.||:..|  .|..|..::...|:           .||.:        |.::.|.|:|.:.
  Rat   195 NSTKLFTLITENFKNVNFTTVQRKYFNE-----------TKGLEYIEQLCIAEFSSVLMEVQSRY 248

  Fly   263 ASNALKTA-IKYLDLVNDAGNLGHYEIKQLDL-----NRFVHLDSAAVAALNIMPKPGTHPSMPS 321
            ...|...| :||::.:.::    .|..|.|.:     .:...:||::...|.::      .:...
  Rat   249 YCLAAAAALLKYVEFIQNS----VYAPKSLKIYFQGSEQTAMIDSSSAQNLELL------VNNQD 303

  Fly   322 YRWQSVL-GVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESP-------------- 371
            ||....| |||::.:|..|.|.:...:.:||.....::.|.:.||.||:..
  Rat   304 YRSNHTLFGVLNYTKTAGGSRRLRSNILEPLVDVETISMRLDCVQELLQDEELFYGLQSVISRFL 368

  Fly   372 DTMETLSLDYLKRIP--DILMLTKK------LMRRKANLQDLFRIYQVILRTPKILKVLHELDNS 428
            ||.:.||:  |.:||  |.:...:.      .::....|.|..::......||.:......|::.
  Rat   369 DTEQLLSV--LVQIPKQDTVNAAESKITNLIYLKHTLELVDPLKVALKNCSTPLLRAYYGSLEDH 431

  Fly   429 TIESVICAPFKSFLKD----LTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSK 489
            .. .:|....|:.:.|    :.|...|..|..         |.|:::....|...::..||:
  Rat   432 RF-GLILEKIKTVINDDARYMKGCLNMRTQKC---------YAVRSNISEFLDIARRTYTEI--- 483

  Fly   490 MEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDD----------------SVLRKNKNYR 538
            ::::....||   |..|..:.|.:.......|.|.:..|                |.::.:.::.
  Rat   484 VDDIAGMISQ---LAEKYSLPLRTSFSSARGFFIQMTTDCAALSSDQLPSEFIKISKVKNSYSFT 545

  Fly   539 IVDVIKGGVRFTSDKLEGYADEF-ASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDC 602
            ..|:||...|......|.|...: ..|:.      ||.:.|.||.       |..|::.::.||.
  Rat   546 SADLIKMNERCQESLREIYHMTYMIVCKL------LSEIYEHIHC-------LYKLSDTVSMLDM 597

  Fly   603 LVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMFIITG 667
            |:|||.|.  ..:.||||:..:    .|.::...||.||.......:||:. :..|..|:.||||
  Rat   598 LLSFAHAC--TLSDYVRPEFTD----TLAIKQGWHPILEKISAEKPVANNT-YITEGSNVLIITG 655

  Fly   668 PNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSG 732
            |||.||||:::.:....:||.||:|||...|:..:...|..|:...|:|....||||.||.|.:.
  Rat   656 PNMSGKSTFLKQIALCQIMAQIGSFVPAQYASFRIAAQIFTRISTDDDIETNSSTFMKEMKEIAY 720

  Fly   733 IIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKN 797
            |:..|.||||::||||||||:|.||.||::::.|||. .||.||||.|||.|:..:......|:|
  Rat   721 ILHNANDKSLILIDELGRGTNTEEGTGISYAVCEHLL-STKAFTLFTTHFLELCHIDTLYLNVEN 784

  Fly   798 CHMA------AVADADDFTLLYQVRSGVM-EKSFGIQVARLANFPEHVVQNAQEV---------Y 846
            .|..      ...:.|.....|::..|:. ||.:|::.|..::.|..:|.:|:|:         .
  Rat   785 MHFEVQHVKNTSRNKDAILYTYKLSRGLTEEKHYGLKAAEASSLPPSIVLDAREITTQITRQISQ 849

  Fly   847 NEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIE 901
            |......:|:|:.........:|||        .|..:..:.|...::...|..|
  Rat   850 NRRSSPEMDRQRAVYHLATRLVQVA--------RNSQLEPDRLRTYLSNLKKKYE 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350
		MutS	174..890	CDD:440019	195/794 (25%)
Msh4	NP_001099947.2	MutS	132..858	CDD:440019	195/785 (25%)