Protein Alignment spel1 and Msh5

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_063135081.1
• Gene: Msh5 / 294252
• RGDID: 1303008
• Length: 852
• Species: Rattus norvegicus
• Alignment Length: 821
• Identity: 209/821 - (25%)
• Similarity: 363/821 - (44%)
• Gaps: 151/821 - (18%)

  Fly   164 VASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIE-GEYSAVKTLLDRNGVMITMPK 227
            |.|.:|::...|.|..|......|.:.      |:..||||:: |...:.:.||..|...|:...
  Rat    98 VTSAKQDEAMTQFLGKLASQEHREPKR------PEIILLPSVDFGPEISKQRLLSGNYSFISESM 156

  Fly   228 KSGDNDLLQDLNRLLRF------AKGQQEDATGLKELQLQLAS--NALKTAIKYLDLVNDAGNLG 284
            .:.:..|.  |:.::.|      .||...|.: :.:|.|.:.|  .||...:|:|........|.
  Rat   157 TATEKILF--LSSIIPFDCVLTPCKGSFPDIS-VAQLSLLVPSQVRALGGLLKFLSRRRVGVELE 218

  Fly   285 HYEI-------KQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYR-------WQSVLGVLDHCR 335
            .|.:       |:..|...|.:|....:.|.|. |..:|||:  |:       ..|:.|:|:.||
  Rat   219 DYSVGVPILGFKKFVLTHLVSIDQDTYSVLQIF-KSESHPSV--YKVASGLKEGLSLFGILNRCR 280

  Fly   336 TPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLS-----LDYLKRIPDILMLTKKL 395
            ...|.:|:..|..:|.|....||.|.::::..| .|..::...     |.::|.:|.||...|..
  Rat   281 CRWGQKLLRLWFTRPTRELRELNSRLDVIEFFL-MPQNLDMAQMMHRLLSHIKNVPLILKRMKLS 344

  Fly   396 MRRKANLQDLFR-IYQVI-LR-----TPKILKVLHELDNSTIESVICAPFKSFLKDLTGLKQMVE 453
            ..:.::.|.|:: :|..: ||     .|:.:::..::.            :.|..||..:..::.
  Rat   345 HTKVSDWQVLYKTVYSALGLRDACRSLPQSIQLFRDIT------------QEFSDDLHHIASLIG 397

  Fly   454 QVVDF-EAIERGEYLVKASFD-------SRLMELQQMMTELYSKMEELQFKCSQELNLDG-KNQV 509
            :|||| |::....:.|..:.|       .|||.|...:||:..|  ||:       |||. ....
  Rat   398 KVVDFEESLAENRFTVLPNIDPEIDAKKRRLMGLPSFLTEVAQK--ELE-------NLDSCIPSC 453

  Fly   510 KLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRF---TSDKLEGYADEFASCRTR---- 567
            .:..:..:|  |.:::...|.:.:..::.|     .|:.|   :.|||     .:.|.||:
  Rat   454 SVIYIPLIG--FLLSIPRLSFMVEASDFEI-----EGLDFMFLSEDKL-----HYRSARTKELDA 506

  Fly   568 --------YEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAAR--SAPTPYVRPKM 622
                    ..:|::.::.::....:..|..||.:.:..::||.|::.|.|||  ....|:..|.:
  Rat   507 LLGDLHCEIRDQEMLLMHQLQCQVLARAPVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCI 571

  Fly   623 LEEGARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTAVLMA 687
              :|.|   :::.|||.:||... .|:.||.|...::..:.:|||||..|||.|::.||....||
  Rat   572 --QGVR---IKNGRHPLMELCAR-TFVPNSTDCGGDQGRVKVITGPNSSGKSIYLKQVGLITFMA 630

  Fly   688 HIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGT 752
            .:|:|||...|.|.::|:|..|:.:.::|..||||||:::.:.:..:..||:.|||:|||.|:||
  Rat   631 LVGSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGT 695

  Fly   753 STYEGCGIAWSIAEH-LAKETKCFTLF-ATHFHEITK--------LAETLSTVKNCHMAAVADAD 807
            ::.:|..:..::..| ||....|..:| ||:|..:.:        |.:.| |::.|.     |.:
  Rat   696 NSVDGLALLTAVLRHWLALGPSCPHIFVATNFLSLVQLQLLPQGPLVQYL-TMETCE-----DGN 754

  Fly   808 DFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAI 872
            |....||:..||...|.....|..|..|:.::...:||.:....   .|..|....|:.:.|
  Rat   755 DLVFFYQLCHGVASASHASYTAAQAGLPDPLIARGKEVSDSIRS---GKPVKPMHELVRRTQ--- 813

  Fly   873 QQLSTAGNNVDINVEDLTQLVTQFTK-DIE--QLDSDYFKS 910
                         :|:...||.:|.| |:|  .||.|.|.|
  Rat   814 -------------MENCQALVDKFLKLDLEDPSLDLDIFIS 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350
		MutS	174..890	CDD:440019	195/786 (25%)
Msh5	XP_063135081.1	None