Protein Alignment spel1 and Msh3

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_034959.2
• Gene: Msh3 / 17686
• MGIID: 109519
• Length: 1095
• Species: Mus musculus
• Alignment Length: 965
• Identity: 247/965 - (25%)
• Similarity: 407/965 - (42%)
• Gaps: 218/965 - (22%)

  Fly    40 RFFDHTDRYTVHGSDDCELVAK----IVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELL 100
            |||          .:|.|:.|:    ..:....|:.|.:|..:    .||.:.:          |
Mouse   215 RFF----------GEDAEIAARELNIYCHLDHNFMTASIPTHR----LFVHVRR----------L 255

  Fly   101 LVRNYRVEVYVKNSSDWEIEYRGSPGNLLQFEDILFS-------NKEVLVGNSIISLLVKLDGG- 157
            :.:.|:|.| ||.:....::..|..      :..:||       .|..|:|.. ::.|::||..
Mouse   256 VAKGYKVGV-VKQTETAALKAIGDN------KSSVFSRKLTALYTKSTLIGED-VNPLIRLDDSV 312

  Fly   158 -----------------------------GQRRVGVASVEQN------DCKFQLLEFLDDDFFTE 187
                                         |...||:..|:..      ||      |.|.....|
Mouse   313 NIDEVMTDTSTNYLLCIYEEKENIKDKKKGNLSVGIVGVQPATGEVVFDC------FQDSASRLE 371

  Fly   188 LEATVVLLGPKECLLPSIEGEYSAVKTLLDRNGVMITMPKKSGDNDLLQDLNR-----------L 241
            ||..:..|.|.|.||||   :.|....:|.:....:::   ..|...::.:|.           :
Mouse   372 LETRISSLQPVELLLPS---DLSVPTEMLIQRATNVSV---RDDRIRVERMNNTYFEYSHAFQTV 430

  Fly   242 LRFAKGQQEDATGLKELQ--LQLASN---ALKTAIKYLDLVNDAGNLGHYE-IKQLDLN-RFVHL 299
            ..|...:..|:.|.:.|.  :.|...   ||...|:||...|....|...| .|||... .|:.:
Mouse   431 TEFYAREIVDSQGSQSLSGVINLEKPVICALAAVIRYLKEFNLEKMLSKPESFKQLSSGMEFMRI 495

  Fly   300 DSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIV 364
            :...:..|.|:.......:..|..|     ||||.:|..|.|.:..||.|||.....:|.|.:.|
Mouse   496 NGTTLRNLEILQNQTDMKTKGSLLW-----VLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAV 555

  Fly   365 QCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDNST 429
            ..:|.|..::.....:.|:::||:......:..:|.:.|:.|.|.:.:.:....|:.|....||.
Mouse   556 SDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKSLCQLKSELQALMPAVNSH 620

  Fly   430 IES-----------VICAPFKSFLKDLTG-------LKQMVEQVVDFEAIERGEYLVKASFDSRL 476
            ::|           .:.:|.:.:||.|.|       ..::.:.:.||..|::.:..::....|..
Mouse   621 VQSDLLRALIVEAPELLSPVEHYLKVLNGPAAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQ 685

  Fly   477 MELQQMMTELYSKMEELQF--KCSQELNLDGKNQ---------VKLESVAKLGH-HFRITVKDDS 529
            |.||:....|  |:..||:  ...||..::.||.         ||:.|...:.. |....|:...
Mouse   686 MRLQEFRKIL--KLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYR 748

  Fly   530 VLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFAS-CRTRYEEQQLSIVEEIIHVAVGYAAPLTLL 593
            .|.:.:...::|.....:.|    ||.:.:.:.: |:                 ||
Mouse   749 RLNQLREQLVLDCNAEWLGF----LENFGEHYHTLCK-----------------AV--------- 783

  Fly   594 NNELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLE--LQEHVNFIANSVDFK 656
             :.||.:||:.|.|..|:..  .|.||.:.||  :::::::.|||.::  |.|...|:.||....
Mouse   784 -DHLATVDCIFSLAKVAKQG--NYCRPTLQEE--KKIIIKNGRHPMIDVLLGEQDQFVPNSTSLS 843

  Fly   657 KEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLS 721
            ::...:.|||||||||||:||:.|....:||.||::||...|||.:||.|..|:||:|||.||.|
Mouse   844 QDSERVMIITGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRS 908

  Fly   722 TFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEIT 786
            |||.|:.:|:.|||.|:.:||||:|||||||||::|..||::..|:..::.|..|||.||:..:.
Mouse   909 TFMEELTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVC 973

  Fly   787 KLAETL-STVKNCHMAAVADADD--------------FTLLYQVRSGVMEKSFGIQVARLANFPE 836
            :|.:.. ..|.|.||..:.:.|:              .|.|||:..|:..:|:|:.||:||:.|.
Mouse   974 ELEKCYPEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPR 1038

  Fly   837 HVVQNAQEVYNEFEDEHVDKQKK-------------------EDKALLEKIQVAI 872
            .|:|.|.....|.|.....::|:                   .||..:|:||.::
Mouse  1039 EVLQKAAHKSKELEGLVSLRRKRLECFTDLWTTHSVKDLHTWADKLEMEEIQTSL 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350	18/95 (19%)
		MutS	174..890	CDD:440019	215/784 (27%)
Msh3	NP_034959.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84
		MutS	183..1052	CDD:440019	240/922 (26%)