Protein Alignment spel1 and Msh6

DIOPT Version :10

• Sequence 1: NP_523565.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001385477.1
• Gene: Msh6 / 100360342
• RGDID: 2322311
• Length: 1362
• Species: Rattus norvegicus
• Alignment Length: 906
• Identity: 235/906 - (25%)
• Similarity: 383/906 - (42%)
• Gaps: 173/906 - (19%)

  Fly   101 LVRNYRVEVYVKNSSDWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVA 165
            :||.....:..|.:..:.: ..|.|..  .:...|.|.||....:|          |..|..||.
  Rat   511 VVRREICRIITKGTQTYSV-LDGDPSE--NYSRYLLSLKEKEEDSS----------GHMRAYGVC 562

  Fly   166 SVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPS----------IEGEYSA--------- 211
            .|:.:..||.|.:|.||...:.|...|....|.:.|...          ::|..|:
  Rat   563 FVDTSLGKFFLGQFSDDRHCSRLRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPG 627

  Fly   212 ---------VKTLLDRNGVMITMPKKSGDNDLLQDLNRLLRFAKGQQEDATGL---KELQLQLAS 264
                     ::|||:  |...|..:.||     .:|..:|: |...:.|:.||   :|.:|.|
  Rat   628 SQFWDATKTLRTLLE--GGYFTGNEGSG-----AELPPVLK-AMTSESDSVGLTPGEESELSL-- 682

  Fly   265 NALKTAIKYL-------DLVNDAGNLGHYEIKQLDL--------------NRFVHLDSAAVAALN 308
            :||...:.||       :|::.| |...|.....|:              .|.| ||:..::.|.
  Rat   683 SALGGCVFYLKKCLIDQELLSMA-NFEEYFPLDSDMVGTVKPGAVFTKASQRMV-LDAVTLSNLE 745

  Fly   309 IMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDT 373
            |... ||:.|...    ::|..||.|.||.|.||:.||:..||.|.:.::||.:.::.|:..||.
  Rat   746 IFLN-GTNGSTEG----TLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAIEDLMAVPDK 805

  Fly   374 METLSLDYLKRIPDILMLTKKLMR-----RKANLQDLFRI---------------------YQVI 412
            :..:: |.||::||:..|..|:..     :..|..|...|                     ::|:
  Rat   806 VAEVA-DLLKKLPDLERLLSKIHNVGSPLKSQNHPDTRAIMYEETTYSKKKIIDFLSALEGFKVM 869

  Fly   413 LRTPKILK-VLHELDNSTIESVICAPFKS---FLKDLTGLKQMVEQVVDFE-AIERGEYLVKASF 472
            .:..:::: |.....:.|::.|:....||   ...|||......:...|.| |.:.|....||.|
  Rat   870 CKITRLMEDVADGFKSKTLKQVVTLQTKSPKGRFPDLTAELNRWDTAFDHEKARKTGLITPKAGF 934

  Fly   473 DSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRK-NKN 536
            ||   :..|.:.::....:.|.....::.:..|...:....:.:  :.:::.:.::...|. .:.
  Rat   935 DS---DYDQALADIRENEQSLLEYLDKQRSRIGCRNIVYWGIGR--NRYQLEIPENFATRNLPEE 994

  Fly   537 YRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEII------HVAVGYAAPLTLLNN 595
            |.:....||..|:.:..:|.......:...|.:......:..:.      |.....|...|
  Rat   995 YELKSTKKGCKRYWTKVIEKKLSNLINAEERRDASLKDCMRRLFYNFDKNHKDWQSAVECT---- 1055

  Fly   596 ELAQLDCLVSFAIAARSAPTPYVRPKML---EEGARELVLEDVRHPCL-ELQEHVNFIANSVDFK 656
              |.||.|:..|..::....|..||.:|   |:....|.|:..||||: :.....:||.|.:...
  Rat  1056 --AVLDVLLCLASYSQGGDGPMCRPVLLLPGEDTHPFLELKGSRHPCITKTFFGDDFIPNDILIG 1118

  Fly   657 KEE---------CNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGA 712
            .||         |  .::||||||||||.||..|...:||.:|.:||..|..::.||.:..|:||
  Rat  1119 CEEDAEADGKAYC--VLVTGPNMGGKSTLIRQAGLLAVMAQMGCYVPAELCRLTPVDRVFTRLGA 1181

  Fly   713 SDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTL 777
            ||.|:.|.|||.||:.||:.|:|.||..|||::|||||||:|::|..||.::.:.||:..||.||
  Rat  1182 SDRIMSGESTFFVELSETASILRHATAHSLVLVDELGRGTATFDGTAIASAVVKELAETIKCRTL 1246

  Fly   778 FATHFHEITKLAETLSTVKNCHMAAVAD-------ADDFTLLYQVRSGVMEKSFGIQVARLANFP 835
            |:||:|.:.:.......|:..|||.:.:       .:..|.||:...|...||:|...|||||.|
  Rat  1247 FSTHYHSLVEDYSKNVCVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLP 1311

  Fly   836 EHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQ---QLSTAGNNVDINVEDLTQLV 893
            |.|:|.......||                |::..|:|   ::..|.....:|.|.:.:|:
  Rat  1312 EEVIQKGHRKAREF----------------ERMNQALQLFREVCLASERPTVNSEAIHRLL 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spel1	NP_523565.2	MutS_I	24..132	CDD:426350	5/30 (17%)
		MutS	174..890	CDD:440019	218/828 (26%)
Msh6	NP_001385477.1	PWWP_MSH6	89..192	CDD:438962
		MutS	410..1362	CDD:440019	235/906 (26%)