DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab14 and RAB19

DIOPT Version :9

Sequence 1:	NP_788056.1	Gene:	Rab14 / 34840	FlyBaseID:	FBgn0015791	Length:	239	Species:	Drosophila melanogaster
Sequence 2:	NP_001008749.2	Gene:	RAB19 / 401409	HGNCID:	19982	Length:	217	Species:	Homo sapiens

Alignment Length:	214	Identity:	87/214 - (40%)
Similarity:	128/214 - (59%)	Gaps:	6/214 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AAPYNYNYIFKYIIIGDMGVGKSCLLHQFTEKKFMANCPHTIGVEFGTRIIEVDDKKIKLQIWDT 91
            ||..|::|:||.|:|||..|||:|::..|....:.....:||||:|..|.:::|.||:|:|:|||
Human     9 AADENFDYLFKIILIGDSNVGKTCVVQHFKSGVYTETQQNTIGVDFTVRSLDIDGKKVKMQVWDT 73

  Fly    92 AGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDTRNLTNPSTVIFLIGNKSDLESTR 156
            |||||||.:|:||||.|..|::.||:|||||:..:..|:.:.......:.||.|||||.||...|
Human    74 AGQERFRTITQSYYRSAHAAIIAYDLTRRSTFESIPHWIHEIEKYGAANVVIMLIGNKCDLWEKR 138

  Fly   157 EVTYEEAKEFADENGLM-FLEASAMTGQNVEEAFLETARKIYQNIQEGRLDLNASESGVQHRPSQ 220
            .|.:|:|...|::.||: .||.||...:|:||.|:..|:::   |....|.| ..||.:...|..
Human   139 HVLFEDACTLAEKYGLLAVLETSAKESKNIEEVFVLMAKEL---IARNSLHL-YGESALNGLPLD 199

  Fly   221 PSRTSLSSEATGAKDQCSC 239
            .|.. |.::....|..|:|
Human   200 SSPV-LMAQGPSEKTHCTC 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab14	NP_788056.1	Rab14	34..199	CDD:133322	73/165 (44%)
RAB19	NP_001008749.2	Rab19	15..179	CDD:133267	73/163 (45%)
RAB19	NP_001008749.2	Effector region. /evidence=ECO:0000250	46..54		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910