DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)34Fd and ENP2

DIOPT Version :9

Sequence 1:	NP_609711.1	Gene:	l(2)34Fd / 34839	FlyBaseID:	FBgn0261535	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_011661.2	Gene:	ENP2 / 853048	SGDID:	S000003377	Length:	707	Species:	Saccharomyces cerevisiae

Alignment Length:	734	Identity:	246/734 - (33%)
Similarity:	400/734 - (54%)	Gaps:	77/734 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NDVKIYNLS---AGKSVPDWLTDRRKRSQLMKKVDSRRQIELIQDFDMPGVCTSIRMSPDQQYIL 68
            |||.:|.:|   ..:|:|||:..:||| ||...::.:.::||||||:.......|::|.|.||.:
Yeast     9 NDVSVYQVSGTNVSRSLPDWIAKKRKR-QLKNDLEYQNRVELIQDFEFSEASNKIKVSRDGQYCM 72

  Fly    69 ATGTYKPRVKCFEVSNLSIKFERCFDAEVTTFEVISDDYSKMVFLQCDRYVEIHAAHGRHYRLRI 133
            |||||||::..::.:|||:||:|..|||...|.::|||::|.|.||.||.::.....|.||..||
Yeast    73 ATGTYKPQIHVYDFANLSLKFDRHTDAENVDFTILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRI 137

  Fly   134 PRFGRDMKYHKPSCDMFIVGVGRDIFRLNLERGQFLQPFETDGSCLNACEVNPEHHLLVAGTKEG 198
            |:|||.:.|:|.:||:::...|.:::|||||:|:||.||:.|...:|...:|..:.||.|||:..
Yeast   138 PKFGRSLVYNKVNCDLYVGASGNELYRLNLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAGTETN 202

  Fly   199 TVEAWDPRTKQRCSTLDVAMKLPGVKEFPSVTALKFRN-GLHMGVGTASGHVLIYDIRAKQPLLV 262
            .||.||||::.|.|.|.:...:.. :.| .||...||| ||....||::|:..|||:|..:|.::
Yeast   203 VVEFWDPRSRSRVSKLYLENNIDN-RPF-QVTTTSFRNDGLTFACGTSNGYSYIYDLRTSEPSII 265

  Fly   263 KNHLNRLPIKRLAFNP---AQNAVYSLDEATLKLWDEQTGKQIAYVESTSSFNDFCTIPDTGMFF 324
            |:......||::.:..   .:|.:.:.|:...|:||...||..|.:|.:...||...:|.|||||
Yeast   266 KDQGYGFDIKKIIWLDNVGTENKIVTCDKRIAKIWDRLDGKAYASMEPSVDINDIEHVPGTGMFF 330

  Fly   325 VAQEDVKMMTYYVPAMGPAPRWCSFLDNLTEEIESEVVENVYDDYQFVTAKELAELGMEHLVGSN 389
            .|.|.:.|.|||:|::||:||||||||::|||:|.:..:.||.:|:|:|..::.:|.:.|||||.
Yeast   331 TANESIPMHTYYIPSLGPSPRWCSFLDSITEELEEKPSDTVYSNYRFITRDDVKKLNLTHLVGSR 395

  Fly   390 LLKGYMHGYFMDARLYNKAKAVVEPFAFDRFRKDKIRQEIESERKSRLQ----IESKLPKVNKEL 450
            :|:.||||:|::..||:|...:..|.|:...|:.:||:.||.||:||::    ::....||||.|
Yeast   396 VLRAYMHGFFINTELYDKVSLIANPDAYKDEREREIRRRIEKERESRIRSSGAVQKPKIKVNKTL 460

  Fly   451 ALKIMDEQANPSNSAKQRNVPSLLEDSRFKAMFENADFEVNKSAEEYRLLAPVLNRLDKSKAKEL 515
            ..|:..::.:       :....:|.|.|||.|||:.:|:|::...:::.|.||  :..|...:..
Yeast   461 VDKLSQKRGD-------KVAGKVLTDDRFKEMFEDEEFQVDEDDYDFKQLNPV--KSIKETEEGA 516

  Fly   516 KKRVEVAHVAELHADEAQ----------QREESDNDEDLFGFEKSDGETKDDSGDEASSDDDDRR 570
            .||:.....|| .:||.:          ..|:.::||     |:||.||...|..|..|:.|
Yeast   517 AKRIRALTAAE-ESDEERIAMKDGRGHYDYEDEESDE-----EESDDETNQKSNKEELSEKD--- 572

  Fly   571 EYVKEMKQAYKQVKRQREEEEELEDDEQQPDEISDTAKRPQTNGHSQQPTTNGNRFTMTPLDQHQ 635
              :::|::....::|:::|:|:.|....:....:.|:.:...:.|    .|.|          .|
Yeast   573 --LRKMEKQKALIERRKKEKEQSERFMNEMKAGTSTSTQRDESAH----VTFG----------EQ 621

  Fly   636 GSSLLQQRIKKASLQDRVRVMSQLEGQVTNVGRSLGNRQMTFEVNKQKKSQFHAKKREAEMKKHR 700
            ...||:....|.|.:..:|...:.|.::|.:              .|:||     |::...|..|
Yeast   622 VGELLEVENGKKSNESILRRNQRGEAELTFI--------------PQRKS-----KKDGNYKSRR 667

  Fly   701 EERRSIVRPIKSLRLKKVN 719
            .:..|....|.....||.|
Yeast   668 HDNSSDEEGIDENGNKKDN 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)34Fd	NP_609711.1	WD40	<38..338	CDD:225201	120/303 (40%)
		WD40	<56..214	CDD:295369	71/157 (45%)
		WD40	<149..329	CDD:295369	65/183 (36%)
		WD40 repeat	179..215	CDD:293791	15/35 (43%)
		WD40 repeat	230..264	CDD:293791	14/34 (41%)
		WD40 repeat	271..305	CDD:293791	10/36 (28%)
		BTV_NS2	<396..584	CDD:282383	56/201 (28%)
		NUC153	476..503	CDD:285385	10/26 (38%)
ENP2	NP_011661.2	WD40	1..>311	CDD:225201	119/304 (39%)
		WD40 repeat	183..225	CDD:293791	16/41 (39%)
		WD40 repeat	232..267	CDD:293791	14/34 (41%)
		WD40 repeat	274..309	CDD:293791	9/34 (26%)
		NUC153	479..507	CDD:400467	12/29 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345381
Domainoid	1	1.000	374	1.000	Domainoid score	I116
eggNOG	1	0.900	-	-		E1_KOG2321
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5998
Inparanoid	1	1.050	413	1.000	Inparanoid score	I299
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53939
OrthoFinder	1	1.000	-	-		FOG0003665
OrthoInspector	1	1.000	-	-		oto98974
orthoMCL	1	0.900	-	-		OOG6_102419
Panther	1	1.100	-	-	LDO	PTHR14927
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R825
SonicParanoid	1	1.000	-	-		X2538
TreeFam	1	0.960	-	-
	15	14.790