DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)34Fd and nol10

DIOPT Version :9

Sequence 1:	NP_609711.1	Gene:	l(2)34Fd / 34839	FlyBaseID:	FBgn0261535	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_956531.1	Gene:	nol10 / 393206	ZFINID:	ZDB-GENE-040426-764	Length:	722	Species:	Danio rerio

Alignment Length:	723	Identity:	334/723 - (46%)
Similarity:	482/723 - (66%)	Gaps:	52/723 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVNEVNDVKIYNLSAGKSVPDWLTDRRKRSQLMKKVDSRRQIELIQDFDMPGVCTSIRMSPDQQ 65
            |.|:.||:|||||||.|||:|:||:||:||....|.||.:|:|||||||:||.||||||:|.|.|
Zfish     1 MQVSSVNNVKIYNLSHGKSLPEWLSDRKKRVLQKKDVDIQRRIELIQDFEMPTVCTSIRVSRDGQ 65

  Fly    66 YILATGTYKPRVKCFEVSNLSIKFERCFDAEVTTFEVISDDYSKMVFLQCDRYVEIHAAHGRHYR 130
            ||||.|||||||:|::...||:|||||.|::|.||:::||||||:|||..|||||.|:.||.:|:
Zfish    66 YILAAGTYKPRVRCYDTYQLSLKFERCLDSDVVTFDILSDDYSKLVFLHIDRYVEFHSQHGHYYK 130

  Fly   131 LRIPRFGRDMKYHKPSCDMFIVGVGRDIFRLNLERGQFLQPFETDGSCLNACEVNPEHHLLVAGT 195
            .|||:||||..||.||||::.||...::||||||:|:||...:||.:.:|.|::||.|.|..|||
Zfish   131 TRIPKFGRDFSYHSPSCDLYFVGASSEVFRLNLEQGRFLNSLQTDAAEMNVCDINPVHQLFAAGT 195

  Fly   196 KEGTVEAWDPRTKQRCSTLDVAMKL----PGVKEFPSVTALKFRNGLHMGVGTASGHVLIYDIRA 256
            .||.|:.||||.:.|.:.||.|:..    ..|:..|||:||||.:.|.:.|||::|.:|:||:|:
Zfish   196 LEGRVDCWDPRVRTRVAALDCALSSITDNTEVEGLPSVSALKFNDSLGLAVGTSTGQILVYDLRS 260

  Fly   257 KQPLLVKNHLNRLPIKRLAFNPAQNAVYSLDEATLKLWDEQTGKQIAYVESTSSFNDFCTIPDTG 321
            .:|||||:|...||||.|.|:.:.:.|.|.|...:|:|::..||..:.:|..::.||.|..|.:|
Zfish   261 SRPLLVKDHYYGLPIKSLHFHNSLDLVLSADSKIIKMWNKDNGKVFSSIEPQANINDVCLYPASG 325

  Fly   322 MFFVAQEDVKMMTYYVPAMGPAPRWCSFLDNLTEEIESEVVENVYDDYQFVTAKELAELGMEHLV 386
            |.|.|.||.||.|:|:||:||||||||||||||||:|......:||||:|||.|:|..||:.||:
Zfish   326 MLFTANEDPKMNTFYIPALGPAPRWCSFLDNLTEELEENPESTIYDDYKFVTRKDLESLGLAHLI 390

  Fly   387 GSNLLKGYMHGYFMDARLYNKAKAVVEPFAFDRFRKDKIRQEIESERKSRLQIESKLPKVNKELA 451
            ||.||:.||||:|||.|||:|.|.:|.|||::.:|||||||:||..|..|:|:: ||||||||||
Zfish   391 GSPLLRAYMHGFFMDIRLYHKVKTMVNPFAYEEYRKDKIRQKIEESRAQRVQLK-KLPKVNKELA 454

  Fly   452 LKIMDEQANPSNSAKQR--NVP-SLLEDSRFKAMFENADFEVNKSAEEYRLLAPVLNRLDKSKAK 513
            ||:|:|....:|..|::  ||. :||.|.|||.||||.|::|::.:||:|||.|:::.:.:.:.|
Zfish   455 LKLMEEDTELTNKKKKKKANVAGNLLMDDRFKVMFENPDYQVDERSEEFRLLNPIISNVAERRRK 519

  Fly   514 ELKKRVEVAHVAELHADEAQQREESDNDEDLFGFEKSDGETKDDSGDEASSDDDDRREYVKEMKQ 578
            .|.:            :|.:|.||....|       ..|.::|||.||   ||....:.|:|.::
Zfish   520 SLLE------------EEQEQAEEEQEPE-------GRGSSEDDSSDE---DDKGWVQEVREQRR 562

  Fly   579 AYKQVKRQR---EEEEELEDDEQQPDEISDTAKRPQTNGHSQQP----TTNGNRF-TMTPLDQHQ 635
            ..:..:|:|   :.:|..:.|.....:.|||..: |::| :|:|    ..:|..| :.:.:.:
Zfish   563 LLRMEERERSYIQRQERRQQDRNTRLQSSDTHTQ-QSHG-AQKPRFYQIKSGEEFRSFSDVSR-- 623

  Fly   636 GSSLLQQRIKKASLQDRVRVMSQLEGQVTNVGRSLGNRQMTFEVNKQKKSQFHAKKREAEMKKHR 700
                 :|:..||||::|::.:.:.:....| ..::|::|:||.:.|.:|.:|   :::|| :.|.
Zfish   624 -----KQKTHKASLEERLQRLEKSDTLSLN-DTAVGSKQLTFTLKKTEKQRF---QQQAE-RDHH 678

  Fly   701 EERRSIVR 708
            ||||.|.|
Zfish   679 EERRRIRR 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)34Fd	NP_609711.1	WD40	<38..338	CDD:225201	158/303 (52%)
		WD40	<56..214	CDD:295369	91/157 (58%)
		WD40	<149..329	CDD:295369	78/183 (43%)
		WD40 repeat	179..215	CDD:293791	17/35 (49%)
		WD40 repeat	230..264	CDD:293791	17/33 (52%)
		WD40 repeat	271..305	CDD:293791	11/33 (33%)
		BTV_NS2	<396..584	CDD:282383	79/190 (42%)
		NUC153	476..503	CDD:285385	15/26 (58%)
nol10	NP_956531.1	WD40	<4..311	CDD:225201	164/306 (54%)
		WD 1	50..90		26/39 (67%)
		WD40	121..337	CDD:295369	98/215 (46%)
		WD 2	174..213		19/38 (50%)
		WD40 repeat	180..215	CDD:293791	17/34 (50%)
		WD 3	228..266		18/37 (49%)
		WD40 repeat	233..267	CDD:293791	17/33 (52%)
		WD 4	270..308		13/37 (35%)
		WD40 repeat	275..311	CDD:293791	11/35 (31%)
		WD 5	310..349		20/38 (53%)
		NUC153	482..508	CDD:285385	15/25 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..555		14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..607		9/36 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..635		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..722		11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590713
Domainoid	1	1.000	561	1.000	Domainoid score	I233
eggNOG	1	0.900	-	-		E1_KOG2321
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5998
Inparanoid	1	1.050	637	1.000	Inparanoid score	I802
OMA	1	1.010	-	-		QHG53939
OrthoDB	1	1.010	-	-		D1099332at2759
OrthoFinder	1	1.000	-	-		FOG0003665
OrthoInspector	1	1.000	-	-		oto40184
orthoMCL	1	0.900	-	-		OOG6_102419
Panther	1	1.100	-	-	LDO	PTHR14927
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R825
SonicParanoid	1	1.000	-	-		X2538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800