Protein Alignment l(2)34Fd and Nol10

DIOPT Version :10

• Sequence 1: NP_609711.1
• Gene: l(2)34Fd / 34839
• FlyBaseID: FBgn0261535
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001008421.1
• Gene: Nol10 / 217431
• MGIID: 2684913
• Length: 687
• Species: Mus musculus
• Alignment Length: 727
• Identity: 325/727 - (44%)
• Similarity: 472/727 - (64%)
• Gaps: 63/727 - (8%)

  Fly     1 MFVNEVNDVKIYNLSAGKSVPDWLTDRRKRSQLMKKVDSRRQIELIQDFDMPGVCTSIRMSPDQQ 65
            |.|:.:|:||||:||.|||:|:||:||:||:...|.||.||:|||||||:||.|||:|::|.|.|
Mouse     1 MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKNVDVRRRIELIQDFEMPTVCTTIKVSKDGQ 65

  Fly    66 YILATGTYKPRVKCFEVSNLSIKFERCFDAEVTTFEVISDDYSKMVFLQCDRYVEIHAAHGRHYR 130
            ||||||||||||:|::...||:|||||.|:||.|||::||||||:|||..|||:|.|:..|.:|:
Mouse    66 YILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIEFHSQSGFYYK 130

  Fly   131 LRIPRFGRDMKYHKPSCDMFIVGVGRDIFRLNLERGQFLQPFETDGSCLNACEVNPEHHLLVAGT 195
            .|||:||||..||.||||::.||...:::|||||:|::|.|.:||.:..|.|::|..|.|...||
Mouse   131 TRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENNVCDINAVHGLFATGT 195

  Fly   196 KEGTVEAWDPRTKQRCSTLDVAMKL----PGVKEFPSVTALKFRNGLHMGVGTASGHVLIYDIRA 256
            .||.||.||||.::|...||.|:..    ..:...|:::||||...|.|.|||::|.||:||:|:
Mouse   196 IEGRVECWDPRVRKRVGVLDCALNSVTADSEINSLPTISALKFNGALSMAVGTSTGQVLLYDLRS 260

  Fly   257 KQPLLVKNHLNRLPIKRLAFNPAQNAVYSLDEATLKLWDEQTGKQIAYVESTSSFNDFCTIPDTG 321
            .:|||||:|...||||.:.|..:.:.|.|.|...:|:|::.:||....:|.....||.|..|.:|
Mouse   261 DKPLLVKDHQYGLPIKSVHFQDSLDLVLSADSRIVKMWNKDSGKIFTSLEPEHDLNDVCLYPSSG 325

  Fly   322 MFFVAQEDVKMMTYYVPAMGPAPRWCSFLDNLTEEIESEVVENVYDDYQFVTAKELAELGMEHLV 386
            |...|.|..||..||:|.:||||||||||||||||:|......|||||:|||.|:|..||:.||:
Mouse   326 MLLTANESPKMGIYYIPVLGPAPRWCSFLDNLTEELEENPESTVYDDYKFVTKKDLENLGLTHLI 390

  Fly   387 GSNLLKGYMHGYFMDARLYNKAKAVVEPFAFDRFRKDKIRQEIESERKSRLQIESKLPKVNKELA 451
            ||..|:.||||:|||.|||:|.|.:|.|||::.:|||||||:||..|..|:|:: ||||||||||
Mouse   391 GSPFLRAYMHGFFMDIRLYHKVKLMVNPFAYEEYRKDKIRQKIEETRAQRVQLK-KLPKVNKELA 454

  Fly   452 LKIMDEQANPSNSA---KQRNVPSLLEDSRFKAMFENADFEVNKSAEEYRLLAPVLNRLDKSKAK 513
            ||:::|:.....|.   |.:::|::|.|.|||.||||.||:|::.:||:|||.|:::|:.:.:.|
Mouse   455 LKLIEEEEEKQKSTLKKKVKSLPNILTDDRFKVMFENPDFQVDEESEEFRLLNPLVSRISEKRKK 519

  Fly   514 ELKKRVEVAHVAELHADEAQQREESDNDEDLFGFEKSDGETKDDSGDEASSDDDDRREYVKEMK- 577
            :|:.              .:|:|..|.:|     |:.:|:..|   .|:|...||.:.:|:|::
Mouse   520 QLRL--------------LEQQELKDEEE-----EEPEGKPSD---AESSESSDDEKGWVEEVRK 562

  Fly   578 -----QAYKQVKRQREEEEELEDDEQQPDEISDTAKRPQTNGHSQQPTTNGNRFTMTPLDQHQGS 637
                 |..::||||    |:|::|:|       |..:||.     .....|..|      :....
Mouse   563 QRRLLQQEERVKRQ----EQLKEDQQ-------TVLKPQF-----YEIKAGEEF------RSFKE 605

  Fly   638 SLLQQRIKKASLQDRVRVMSQLEGQVTNVGRSLGNRQMTFEVNKQKKSQFHAKKREAEMKKHREE 702
            |..:||:...:|:||:::.:: .|.:.....::|::|:||.:   |:|:...|::||| |.||:|
Mouse   606 SATKQRLMNKTLEDRLKLEAK-HGTLNVSDTTVGSKQLTFTL---KRSEQQKKQQEAE-KLHRQE 665

  Fly   703 RRSIVRPIKSLR 714
            |:::.|....||
Mouse   666 RKNLRRSASHLR 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)34Fd	NP_609711.1	WD40	<56..214	CDD:475233	88/157 (56%)
		WD40	<150..303	CDD:441893	65/156 (42%)
		WD40 repeat	179..215	CDD:293791	16/35 (46%)
		WD40 repeat	230..264	CDD:293791	19/33 (58%)
		WD40 repeat	271..305	CDD:293791	10/33 (30%)
		BTV_NS2	<396..584	CDD:282383	77/196 (39%)
		NUC153	476..503	CDD:462385	16/26 (62%)
Nol10	NP_001008421.1	WD 1	50..90		25/39 (64%)
		WD40 repeat	55..95	CDD:293791	26/39 (67%)
		WD40 repeat	108..153	CDD:293791	25/44 (57%)
		WD40 repeat	158..219	CDD:293791	29/60 (48%)
		WD 2	174..213		18/38 (47%)
		WD40	<182..339	CDD:475233	63/156 (40%)
		WD40 repeat	228..268	CDD:293791	20/39 (51%)
		WD 3	228..266		18/37 (49%)
		WD 4	270..308		12/37 (32%)
		WD40 repeat	275..310	CDD:293791	10/34 (29%)
		WD 5	310..349		17/38 (45%)
		NUC153	482..508	CDD:462385	16/25 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..560		12/41 (29%)
		CCDC34	<560..>667	CDD:464032	35/133 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..687		16/39 (41%)