DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(2)34Fd and nol-10

DIOPT Version :9

Sequence 1:	NP_609711.1	Gene:	l(2)34Fd / 34839	FlyBaseID:	FBgn0261535	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_501233.1	Gene:	nol-10 / 177538	WormBaseID:	WBGene00017989	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	289/766 - (37%)
Similarity:	458/766 - (59%)	Gaps:	73/766 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVNEVNDVKIYNLSAGKSVPDWLTDRRKRSQLMKKVDSRRQIELIQDFDMPGVCTSIRMSPDQQ 65
            |.|:.||||||||||||||:|:|::.|.:|....:..|.|::|:|||||:||.|..::.::||.:
Worm     1 MEVSTVNDVKIYNLSAGKSLPEWMSSRTRRKLEQRNTDVRQRIQLIQDFEMPDVSNTVNITPDGK 65

  Fly    66 YILATGTYKPRVKCFEVSNLSIKFERCFDAEVTTFEVISDDYSKMVFLQCDRYVEIHAAHGRHYR 130
            |:.|:|.|||.::|::::|||:||||..||:|.....:||||||:|.|:.:|::|:||..||::|
Worm    66 YVWASGNYKPWLRCYDLNNLSLKFERGLDADVIKLIPLSDDYSKVVILEEERWIEMHAMLGRYFR 130

  Fly   131 LRIPRFGRDMKYHKPSCDMFIVGVGRDIFRLNLERGQFLQPFETDGSCLNACEVNPEHHLLVAGT 195
            :|:|..||||...:.|.|:::||...:::|.|||:|.:|.|||:... ||..:|..||.|:..||
Worm   131 MRMPCQGRDMALSEESSDLYLVGSKSEVYRFNLEQGCWLTPFESTAP-LNCVQVCTEHQLICCGT 194

  Fly   196 KEGTVEAWDPRTKQRCSTLDVAMKLP---GVKEFPSVTALKFRNGLHMGVGTASGHVLIYDIRAK 257
            ..|.|||||.|.|..|.|||....:.   |..:..:||::.|.:.||:||||::|.:||||:||:
Worm   195 TNGVVEAWDHRDKSLCGTLDAGSSVNSHIGENQKVAVTSVAFSDPLHIGVGTSTGQILIYDLRAR 259

  Fly   258 QPLLVKNHLNRLPIKRLAF--NPAQNAVYSLDEATLKLWDEQTGKQIAYVESTSSFNDFCTIPDT 320
            :|||:|:|.|.|||.:|.|  ....:.|.|:|...:|||.|:.|..:|.:|:|...||||..|::
Worm   260 RPLLIKDHNNELPINKLDFIKRDDGDVVASMDSRMMKLWHEEDGSPMAAIENTCPLNDFCRFPNS 324

  Fly   321 GMFFVAQEDVKMMTYYVPAMGPAPRWCSFLDNLTEEIESEVVENVYDDYQFVTAKELAELGMEHL 385
            ||||.|.|..||:.|::|.:||||:|||:|:|||||:| |....|||:|:|||.|:|.:||:..|
Worm   325 GMFFFANEAPKMLQYFIPQLGPAPKWCSYLENLTEEME-ETETTVYDNYRFVTKKQLDDLGLSGL 388

  Fly   386 VGSNLLKGYMHGYFMDARLYNKAKAVVEPFAFDRFRKDKIRQEIESERKS---RLQIESKLPKVN 447
            :|:|:|:.||||||:||||||||:..::|||:::::.:||:..|..||:.   :.::| |||.||
Worm   389 IGTNVLRAYMHGYFIDARLYNKAQTQMQPFAYEKYKDEKIKSMIADEREESAVKKKVE-KLPAVN 452

  Fly   448 KELALKIMDEQANPSN-----------SAKQRNVPSLLEDSRFKAMFENADFEVNKSAEEYRLLA 501
            |.||.::.|| |:.:|           |.|.....|||.|.|||.:||:.||||::::|::...|
Worm   453 KALAARLRDE-ASAANQKAETKKEKKKSKKSDAATSLLADDRFKKLFESEDFEVDETSEQFLKNA 516

  Fly   502 PVLNRLDKSKAKELKKRVEVAHVAELHADEAQQREESDNDEDLFGFEKSDGETKDDSG------- 559
            .:..::      :.|..|||    |...:|::..:.||::.:..|   ||.|.|..:.
Worm   517 SIAQKM------KAKGPVEV----ESEGEESEDNDASDSENEASG---SDSEPKGSASWMVEENR 568

  Fly   560 --------DEASSDDD------DRREYVKEMKQAYKQVKR-----QREEEEELEDDEQQPDEISD 605
                    :.||||:|      .:|..|:..|::.:.:::     :|:|.:::..:::|..:.|.
Worm   569 EVDMASDLESASSDEDIDQSLKAKRAKVRAAKKSERNIQKSQKYDERKEAKKIRKEQRQLSKPSK 633

  Fly   606 TAKRPQTNGHSQQPTTNGNRFTMTPLDQHQGSSLLQQRIKKASLQDRVRVMSQLEGQVTNVGRSL 670
            ........|.:.:...:.........| ::.|..|..|.:..:..||      ...:|.:.....
Worm   634 FVLHSIGTGETTRKFVDETVAVRDDAD-NKDSMALGARKRATARSDR------KTKKVNDDDVPF 691

  Fly   671 GNRQMTFEVNKQKKSQFHAKKREAEMKKHREERRSIVRPIKSL---RLKKV 718
            |.|:|||.::|:.| ...|:..:.:...|..||:.:.|...:|   .|||:
Worm   692 GGREMTFTISKRDK-DLRAEAAKTKQAAHAAERKEVSRRPNALVTKGLKKL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)34Fd	NP_609711.1	WD40	<38..338	CDD:225201	137/304 (45%)
		WD40	<56..214	CDD:295369	70/157 (45%)
		WD40	<149..329	CDD:295369	80/184 (43%)
		WD40 repeat	179..215	CDD:293791	18/35 (51%)
		WD40 repeat	230..264	CDD:293791	18/33 (55%)
		WD40 repeat	271..305	CDD:293791	12/35 (34%)
		BTV_NS2	<396..584	CDD:282383	71/222 (32%)
		NUC153	476..503	CDD:285385	12/26 (46%)
nol-10	NP_501233.1	WD40 repeat	139..171	CDD:293791	12/31 (39%)
		WD40	<175..310	CDD:392136	57/135 (42%)
		WD40 repeat	178..214	CDD:293791	18/35 (51%)
		WD40 repeat	231..266	CDD:293791	19/34 (56%)
		WD40 repeat	273..298	CDD:293791	7/24 (29%)
		PTZ00108	<419..664	CDD:240271	63/260 (24%)
		NUC153	491..>514	CDD:369723	11/22 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164103
Domainoid	1	1.000	459	1.000	Domainoid score	I243
eggNOG	1	0.900	-	-		E1_KOG2321
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5998
Inparanoid	1	1.050	504	1.000	Inparanoid score	I735
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53939
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003665
OrthoInspector	1	1.000	-	-		oto17279
orthoMCL	1	0.900	-	-		OOG6_102419
Panther	1	1.100	-	-	LDO	PTHR14927
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R825
SonicParanoid	1	1.000	-	-		X2538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790