DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Send2 and GZMB

DIOPT Version :9

Sequence 1:NP_609708.2 Gene:Send2 / 34836 FlyBaseID:FBgn0264253 Length:239 Species:Drosophila melanogaster
Sequence 2:NP_004122.2 Gene:GZMB / 3002 HGNCID:4709 Length:247 Species:Homo sapiens


Alignment Length:258 Identity:76/258 - (29%)
Similarity:107/258 - (41%) Gaps:53/258 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IQSFLLLLA---LNSLSAGPVIRPEERIIGGQPIGIEEAPW--------QVSIQRDGKHLCGGSI 56
            :|..|||||   |....||       .||||........|:        |.|::|     |||.:
Human     1 MQPILLLLAFLLLPRADAG-------EIIGGHEAKPHSRPYMAYLMIWDQKSLKR-----CGGFL 53

  Fly    57 YSADIIITAAHCVQGQGYQVRAGS-ALKNSNGSVVDVAAIR-------THEGLGNDIAIVRLSKP 113
            ...|.::||||| .|....|..|: .:|....:...:...|       ..:...|||.:::|.:.
Human    54 IRDDFVLTAAHC-WGSSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERK 117

  Fly   114 LEFTNQVQP--IPLAKTNPPPGSIAFVSGWGSSS---YYSHPIDLQGVNLYIQWP---------Y 164
            .:.|..|||  :|..|....||....|:|||.::   .:||  .||.|.:.:|..         |
Human   118 AKRTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSH--TLQEVKMTVQEDRKCESDLRHY 180

  Fly   165 YCGLTEPSRICAG--SFGRAACKGDSGGPLVFDQQLVGVVSGGTKDCTYSSIYTSVPYFREWI 225
            |....|   :|.|  ...:.:.|||||||||.::...|:||.|..:.......|.|..|..||
Human   181 YDSTIE---LCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSSFVHWI 240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Send2NP_609708.2 Tryp_SPc 26..225 CDD:214473 65/230 (28%)
Tryp_SPc 27..225 CDD:238113 65/229 (28%)
GZMBNP_004122.2 Tryp_SPc 20..240 CDD:214473 65/230 (28%)
Tryp_SPc 21..243 CDD:238113 67/231 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1076876at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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