DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Send2 and PRSS58

DIOPT Version :9

Sequence 1:NP_609708.2 Gene:Send2 / 34836 FlyBaseID:FBgn0264253 Length:239 Species:Drosophila melanogaster
Sequence 2:NP_001001317.1 Gene:PRSS58 / 136541 HGNCID:39125 Length:241 Species:Homo sapiens


Alignment Length:252 Identity:64/252 - (25%)
Similarity:101/252 - (40%) Gaps:44/252 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 FLLLLALNSLSAGPVIRPEERIIGGQPIGIEEAPWQVSIQRDGKHL-CGGSIYSADIIITAAHCV 69
            |:||.||.:|:......| :..:...|      |:.|.::.|  :| |.|.:.....:||||||.
Human     3 FILLWALLNLTVALAFNP-DYTVSSTP------PYLVYLKSD--YLPCAGVLIHPLWVITAAHCN 58

  Fly    70 QGQ-----GYQVRAGSALKNSNGSVVDVAAIRTH-----EGLGNDIAIVRLSKPLEFTNQVQPIP 124
            ..:     |..:.|.|..|:.  .|:....:..|     ..:.:||.:::|....|..:.|:...
Human    59 LPKLRVILGVTIPADSNEKHL--QVIGYEKMIHHPHFSVTSIDHDIMLIKLKTEAELNDYVKLAN 121

  Fly   125 LAKTNPPPGSIAFVSGWGSSSY-----YSHPIDLQGVNLYIQWPYYC-------GLTEPSRICAG 177
            |........::..||.|   ||     |..|..||.||:.:.....|       .:|| :.:|.|
Human   122 LPYQTISENTMCSVSTW---SYNVCDIYKEPDSLQTVNISVISKPQCRDAYKTYNITE-NMLCVG 182

  Fly   178 SF--GRAACKGDSGGPLVFDQQLVGVVSGGTKDCTYSS---IYTSVPYFREWILNAI 229
            ..  .|..||..|..|.:.:..|.|::| ....|...:   ||..:.|:..||.|.|
Human   183 IVPGRRQPCKEVSAAPAICNGMLQGILS-FADGCVLRADVGIYAKIFYYIPWIENVI 238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Send2NP_609708.2 Tryp_SPc 26..225 CDD:214473 53/226 (23%)
Tryp_SPc 27..225 CDD:238113 53/225 (24%)
PRSS58NP_001001317.1 Tryp_SPc 29..234 CDD:214473 52/213 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147431
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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