DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33090 and APL3

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_009516.1	Gene:	APL3 / 852243	SGDID:	S000000133	Length:	1025	Species:	Saccharomyces cerevisiae

Alignment Length:	343	Identity:	64/343 - (18%)
Similarity:	121/343 - (35%)	Gaps:	103/343 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 YDDPRLAYGRFGYLEGHEYRMYNTYDVHFYA---SPALAHLWPNLQVSLQYDFKDAIAAEL---N 555
            :|..:...|....|.|::.:.|.....:.|.   :..|..:...|:.:::. .|.:|.:|.   .
Yeast    53 FDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTTKLNEILFGLEQTVEL-LKSSIFSEKFIGY 116

  Fly   556 DTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNT---KFVLQVYRDYY 617
            .|.::||:...:..||.          ||..:.|:           |||::   .||:.......
Yeast   117 MTLELLYERSEVVAKVN----------DEVNYQLM-----------KDLSSSDDNFVMLALNFVG 160

  Fly   618 VLNELAQ--AQSDN---------ASKFSSIEFIDKESL---------YELYSQDNKRK------- 655
            |:.||..  |.:|:         .|..|||....|.:|         :.:.::|.:||
Yeast   161 VVGELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRKQLWIQRI 225

  Fly   656 -NSADEKQQNRKSASMYINETNGKVYLMDAIG-YLKAMYASCKAIMERTIEY-----------DK 707
             :..|:.:..|.        |...:.|::.|. |:...|  |..::.:..|.           ..
Yeast   226 LSLLDDTENYRL--------TLATIPLIEFIAKYIDPSY--CTRLLPQLTEILYNCVVVGTSRSS 280

  Fly   708 DNDGLIENT--KMPDQTYDSWVMD-----------GPSAYCSGLWLAALQAMSAMATILDQPNDC 759
            ||...:|.|  .||    :.|::.           .|:...||   :.||..:....:|::...|
Yeast   281 DNQFPLEYTFANMP----NPWLITKVVSLLSILIASPTERDSG---SLLQTNNIDNELLNKLRKC 338

  Fly   760 LRYQDILEKGKRSLEEKL 777
            :..  .:|.|.|..::.:
Yeast   339 VSV--AIELGTRQAQDPM 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	63/335 (19%)
APL3	NP_009516.1	Adaptin_N	38..649	CDD:396262	64/343 (19%)
APL3	NP_009516.1	Alpha_adaptin_C	901..1018	CDD:367023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900