DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33090 and GBA2

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	XP_006716872.1	Gene:	GBA2 / 57704	HGNCID:	18986	Length:	933	Species:	Homo sapiens

Alignment Length:	925	Identity:	377/925 - (40%)
Similarity:	524/925 - (56%)	Gaps:	129/925 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VPKYGLKLKFDHVWPEKR--IQNVRASIRQTLPMVPLVCRYAA-YYWKVSREGRRVYMDYYYMEN 111
            ||.:|.::...|.:.|||  .|....|:...:..:.:..||.. :|.|...|.:..::|......
Human    81 VPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLRYLQWWYRKTHVEKKTPFIDMINSVP 145

  Fly   112 GKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIK-----DPKGCTIFQS 171
            .:||||.|:||||||||.||:.|:|||:|:.||:|::..|:|:|.|..:|     ..:|.|::|.
Human   146 LRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHRTVIADQPICPLKFTVCLRREGQTVYQQ 210

  Fly   172 LLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQP--LSAWHSNIEDTRCSYTGLYPRSWTEY 234
            :||                              .::|  |.:|:..:......|..||||:||.|
Human   211 VLS------------------------------LERPSVLRSWNWGLCGYFAFYHALYPRAWTVY 245

  Fly   235 DLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGNKKQDAEG 299
            .|....|.|||||::|::||:|::||||..||||.|||..|:...|||.|:.:||.|. ..||.|
Human   246 QLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGG-GDDAPG 309

  Fly   300 GAESQLI----SEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNGEQLWAQLKE 360
            |..::..    |....:|:.:.......|.:..:|.||....::|....|||...|:|:|..|.:
Human   310 GLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQQVWQDLLQ 374

  Fly   361 HGQLSEHPTSEALKT-KDIGV--AVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTK 422
            .||| :.||.::..| |.:|:  |||....|:|.....|||.||||||:|.|..|.|.|.|.||:
Human   375 DGQL-DSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFGAKGQVHYRRYTR 438

  Fly   423 YFDDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKC 487
            :|...||:.|.:..|||.:|:.||..|.|||.|:|:|.:||.|||.|:||:|||::||||:||:.
Human   439 FFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSALFNELYFLADGGTVWLEV 503

  Fly   488 --DS---SLGKELAYDDPRLA-YGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDF 546
              ||   .||:.:.:..|.|. |||||||||.|||||||||||||||.||..|||.|::|||||.
Human   504 LEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVHFYASFALIMLWPKLELSLQYDM 568

  Fly   547 KDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQ 611
            ..|...|....|:.|..|.:.|.|.:|.:|||:||||:||:..:|.|.|||..||||||.|||||
Human   569 ALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQ 633

  Fly   612 VYRDYYVLNELAQAQSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNRKSASMYINETN 676
            ||||||:..:                                         ||
Human   634 VYRDYYLTGD-----------------------------------------QN------------ 645

  Fly   677 GKVYLMDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLA 741
                      :||.|:..|.|:||..:::|||:||||||....|||||.||..||||||.|||||
Human   646 ----------FLKDMWPVCLAVMESEMKFDKDHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLA 700

  Fly   742 ALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRD-TIMADQLCGHWY 805
            |:..|..||.:....:...::..||.:|:.:.|..||||.||.:|.|...:. ::|:||..|.|:
Human   701 AVAVMVQMAALCGAQDIQDKFSSILSRGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWF 765

  Fly   806 LKSCGF---DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKPGHVDNSNIQA 867
            ||:||.   |.|::|.::|..||:.|::.||..|..|.:||.||.     :|  .|..|.|::|:
Human   766 LKACGLGEGDTEVFPTQHVVRALQTIFELNVQAFAGGAMGAVNGM-----QP--HGVPDKSSVQS 823

  Fly   868 EEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLS 932
            :|||.||||.|||||||||:..|.||||.|.|:|:.:|:|:.|:||||...::.:||:.||||||
Human   824 DEVWVGVVYGLAATMIQEGLTWEGFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLS 888

  Fly   933 IWSMQVALERRRAQR 947
            ||:||:||::::.::
Human   889 IWAMQLALQQQQHKK 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	115/326 (35%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	195/435 (45%)
GBA2	XP_006716872.1	GBA2_N	166..461	CDD:289023	115/326 (35%)
		DUF608	527..890	CDD:282531	193/432 (45%)
		GDE_C	<625..>753	CDD:283786	66/190 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140672
Domainoid	1	1.000	316	1.000	Domainoid score	I1272
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10859
Inparanoid	1	1.050	626	1.000	Inparanoid score	I867
Isobase	1	0.950	-	0	Normalized mean entropy	S4511
OMA	1	1.010	-	-		QHG63864
OrthoDB	1	1.010	-	-		D207392at2759
OrthoFinder	1	1.000	-	-		FOG0003795
OrthoInspector	1	1.000	-	-		oto90787
orthoMCL	1	0.900	-	-		OOG6_105042
Panther	1	1.100	-	-	LDO	PTHR12654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4019
SonicParanoid	1	1.000	-	-		X2650
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750