DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33090 and gba2

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	XP_005172389.1	Gene:	gba2 / 559240	ZFINID:	ZDB-GENE-070522-3	Length:	851	Species:	Danio rerio

Alignment Length:	934	Identity:	387/934 - (41%)
Similarity:	524/934 - (56%)	Gaps:	130/934 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KLQQQEESNEIA-AVPKYGLKLKFDHVWPEKR--IQNVRASIRQTLPMVPLVCRYAA-YYWKVSR 97
            :|..:..|:|.. .|||.|.::...|.:.|||  .|....|:...|..|.|..||.. :|.|...
Zfish    11 ELMSRYASSETGFGVPKDGWRICLAHEFKEKRKPFQAKDVSLSNMLEHVSLGVRYLKWWYRKTQV 75

  Fly    98 EGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKD 162
            |.:..::|.:.....:||||||:||||||:|.||:.|||||:|:.||:|.|..|:||||.|.::
Zfish    76 EKKAPFIDMFRAVPLRQIYGVPLGGIGGGSITRGWRGEFCRWQLNPGMYHYKTVIANQFTVCLR- 139

  Fly   163 PKGCTIFQSLLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLY 227
            ..|.|::|.:||       |..|                     ..|..|:.........|.||:
Zfish   140 RDGQTVYQQVLS-------TERP---------------------STLQGWNWGYCGEHAFYHGLF 176

  Fly   228 PRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKNGTGN 292
            ||:||.|:|....|.||||||||||||:|::||||.|||||.:||..|....:||.||..||:|
Zfish   177 PRAWTVYNLPGQNVTLTCRQVSPVIPHDYKDSSLPVAVFVWDIENKNDYALDISIMFTMVNGSG- 240

  Fly   293 KKQDAEGGAESQ---LISEG-NAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNGEQ 353
            :|.|..||..::   |..|| :..||.:..:....|.:..:|.|......|:....|.|.|....
Zfish   241 QKDDKSGGHWNEPFHLEKEGESVSGVLLHHQTPANPYTLCIAARQKSGQEISHQTAFSPKGTCSA 305

  Fly   354 LWAQLKEHGQLSEHPTSEALKT---KDIGVAVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQT 415
            :|..|...|:| :.||:.:..|   :::..|:....::...:.:.::|.||||||||.|..|.:|
Zfish   306 VWCDLMTDGRL-DSPTNSSPPTEKGEEVAAALVVSCSVSANSRNSVDFSLAWDMPKITFGSKERT 369

  Fly   416 HTRYYTKYFDDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDG 480
            :.|.||:|:...||:.|.|..|||..||.||..|:.||||||.|.:||.|||.|:||:|||:.||
Zfish   370 YVRRYTRYYGTKGDAAPSISHYALTHYSKWEESIEEWQRPILQDRSLPAWYKSALFNELYFVVDG 434

  Fly   481 GTIWLKC--DSSLGKELAYDDPRLA--------YGRFGYLEGHEYRMYNTYDVHFYASPALAHLW 535
            ||||::.  |:.:...|..:|..|.        :|||.||||.|||||||||||||||.||..||
Zfish   435 GTIWVELPEDADISGGLRPEDGGLPAQPEVVKDFGRFAYLEGQEYRMYNTYDVHFYASFALIMLW 499

  Fly   536 PNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVND 600
            |.|.:|||||...::.......|..|.:|:..|.|.:..||||:||||:||:..:|.|.|||..|
Zfish   500 PKLALSLQYDIAGSVVQHDPMERLNLMNGRYSPVKTRGVVPHDIGDPDDEPWVRVNAYLIHDTAD 564

  Fly   601 WKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNR 665
            |||||.||||||||||::                              :||.:
Zfish   565 WKDLNLKFVLQVYRDYHL------------------------------TQDQQ------------ 587

  Fly   666 KSASMYINETNGKVYLMDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDG 730
                                 |||.|:..|:.:||..:::|||.||||||:...|||||.|.:.|
Zfish   588 ---------------------YLKDMWPVCQTVMENELKFDKDGDGLIENSGYADQTYDGWKVTG 631

  Fly   731 PSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLS-HSHRDT 794
            |||||.|||||::..|..||.:|:..:...||:||||:|..:.::.||||.||.:|.| .|..::
Zfish   632 PSAYCGGLWLASVCMMCKMARVLNCESVYQRYRDILERGSAAFDKLLWNGKYYNYDSSGRSLSNS 696

  Fly   795 IMADQLCGHWYLKSCGF---DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTK 856
            :|:||..|||:|::.|.   :|:.:|||.:.:|||.::|.|||.|..|.:||.||.        :
Zfish   697 VMSDQCAGHWFLRASGLGDDEYQAFPKEKICSALKSVFDLNVMSFAGGQMGAVNGM--------R 753

  Fly   857 P-GHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEK 920
            | |..|.|::|::|||.||||.||||||.|||.||..:||.|.|:.:.:|:||.|:|||| |.||
Zfish   754 PEGVPDRSSVQSDEVWVGVVYGLAATMIHEGMVEEGLRTAEGCYRAVWERMGMAFQTPEA-YCEK 817

  Fly   921 R-YRSIGYMRPLSIWSMQVALERR 943
            . |||:.||||||||:||:||..|
Zfish   818 GIYRSLAYMRPLSIWAMQLALNNR 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	116/319 (36%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	198/437 (45%)
gba2	XP_005172389.1	GBA2_N	105..399	CDD:289023	119/324 (37%)
		DUF608	469..836	CDD:282531	199/438 (45%)
		GDE_C	<567..>694	CDD:283786	68/189 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573384
Domainoid	1	1.000	321	1.000	Domainoid score	I1202
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10859
Inparanoid	1	1.050	621	1.000	Inparanoid score	I852
OMA	1	1.010	-	-		QHG63864
OrthoDB	1	1.010	-	-		D207392at2759
OrthoFinder	1	1.000	-	-		FOG0003795
OrthoInspector	1	1.000	-	-		oto40840
orthoMCL	1	0.900	-	-		OOG6_105042
Panther	1	1.100	-	-	LDO	PTHR12654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4019
SonicParanoid	1	1.000	-	-		X2650
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800