DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33090 and ap2a1

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	XP_009297842.1	Gene:	ap2a1 / 558153	ZFINID:	ZDB-GENE-090302-2	Length:	984	Species:	Danio rerio

Alignment Length:	930	Identity:	153/930 - (16%)
Similarity:	262/930 - (28%)	Gaps:	408/930 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 IGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLSKCSTRDKTSD 184
            |..:|...:...:|||..|           :::|...:.::|        || .:.|..|...:.
Zfish   135 IANVGSREMAEAFAGEIPR-----------ILVAGDTMDSVK--------QS-AALCLLRLYKTS 179

  Fly   185 PDGDPDGERTK----------------------C-------QLPNCSSRAKQPLSAWHSNIEDTR 220
            ||....||.|.                      |       :...|.|.|...||...|:.....
Zfish   180 PDLVLMGEWTSRVVHLLNDQHMGVVTAAISLITCLSQKNPDEFKTCVSLAVSRLSRIVSSASTDL 244

  Fly   221 CSYTGLY-PRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITF 284
            ..||..: |..|           |:|:.:..:..:...|........|..:|.:.
Zfish   245 QDYTYYFVPAPW-----------LSCKLLRLLQCYPPPEDGAVKGRLVECLETIL---------- 288

  Fly   285 TFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAG 349
                   ||.|:.   .:|:.:...|||...:.:.|| :...|:..    |.:.:..|.|.
Zfish   289 -------NKAQEP---PKSKKVQHSNAKNAILFEAIS-LIIHYDSE----PNLLVRACNQL---- 334

  Fly   350 NGEQLWAQLKEHGQ--------------LSEHPTSEALKT------------KDIGV-------- 380
                  .|..:|.:              .|...:.||:||            :|:.|
Zfish   335 ------GQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAADLL 393

  Fly   381 -AVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYFDDSGDSGPRICEYALRQYST 444
             |:|.:...|.:.:..|.::                                 ...:|::|:
Zfish   394 YAMCDRSNAKQIVAEMLSYL---------------------------------ETADYSIRE--- 422

  Fly   445 WERLIDAWQRPILNDETLPD--WYKCAIFNQLYFISD--GGTIWLKCDSSLGKELAYDDPRLAYG 505
             |.::..   .||.::...|  ||...|.|.:....|  ...:|
Zfish   423 -EMVLKV---AILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVW--------------------- 462

  Fly   506 RFGYLEGHEYR----MYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYDGKV 566
                     ||    :.|..||..||:..:            ::...|.|...|    |:..|..
Zfish   463 ---------YRVIQIVINRDDVQGYAAKTV------------FEALQAPACHEN----MVKVGGY 502

  Fly   567 MPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKF----------VLQVYRDYYVLNE 621
            :..:..|.:   .|||...|....|.           |::||          :|..|
Zfish   503 ILGEFGNLI---AGDPRSSPLVQFNL-----------LHSKFHLCSVPTRALLLSAY-------- 545

  Fly   622 LAQAQSDNASKFSSIEFID-----KESLYELYSQDNKRKNSADEKQQNRKSASMYINETNGKVYL 681
                          |:||:     |.::.|:...|::.:||..|.||
Zfish   546 --------------IKFINLFPETKSTIQEVLRSDSQIRNSDVELQQ------------------ 578

  Fly   682 MDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAM 746
                               |.:||                                |.|:::.:.
Zfish   579 -------------------RAVEY--------------------------------LKLSSIAST 592

  Fly   747 SAMATILDQ-PNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSCG 810
            ..:||:|:: |....|...||.|    |::|...|:....:|....|:   ..:|.|....:  |
Zfish   593 DVLATVLEEMPPFPERESSILAK----LKKKKGPGAVSVNELEEGKRE---GGELNGGGGER--G 648

  Fly   811 FDYEIYPKENVRTALKRIYDNNVMGFHEG-NIGAA-------------------NGFIANASEPT 855
            .|.......|..|...   ..:::|...| .:.||                   :||:.:...||
Zfish   649 GDNSTIAASNASTPSP---SADLLGLRTGPQVSAAPPSAGSLLVDVFSEAGVNDDGFLRDLEPPT 710

  Fly   856 K---------PGHVDNS--NIQAEEVWP-----------------GVVYALAATMIQEGMFEEAF 892
            :         ||..|::  :..:|:..|                 ||::  ...::|.|:..|..
Zfish   711 ESSDSLLAEGPGDSDSAPPSAVSEDAAPPLPESNELLNKFVCKNNGVLF--ENQLLQIGIKSEYR 773

  Fly   893 QTAGGMYKTLSQRIGMNFET 912
            |..|.||.....:..:.|.|
Zfish   774 QNLGRMYLFYGNKTSVQFVT 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	59/377 (16%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	82/476 (17%)
ap2a1	XP_009297842.1	Adaptin_N	29..591	CDD:279882	110/712 (15%)
		RIX1	141..>292	CDD:285390	33/198 (17%)
		Alpha_adaptinC2	758..861	CDD:197886	9/38 (24%)
		Alpha_adaptin_C	867..979	CDD:280460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900