DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33090 and Ap3d1

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_001094189.1	Gene:	Ap3d1 / 314633	RGDID:	1308659	Length:	1204	Species:	Rattus norvegicus

Alignment Length:	180	Identity:	43/180 - (23%)
Similarity:	67/180 - (37%)	Gaps:	51/180 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 HYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVEN-VCDQERKVSITFTFKNGTGNKKQDAEGGA 301
            |.||.:.. |:.|.:.:|        |.||::::: |..|:.|.:::|..|        |.||..
  Rat  1036 HDGVPVPF-QLPPGVSNE--------AQFVFTIQSIVMAQKLKGTLSFIAK--------DDEGAT 1083

  Fly   302 ESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNGEQLWAQLKEHGQLSE 366
            ..:|         ..|...|   ||..|         || .|.:..|      :|:|.|.|.||
  Rat  1084 HEKL---------DFRLHFS---CSSYL---------IT-TPCYSDA------FAKLLESGDLS- 1119

  Fly   367 HPTSEALKTKDIGVAVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTH 416
               ..::|...|.::....:| |....|....|...|.....:.|.:|.|
  Rat  1120 ---MNSIKVDGISISFQNLLA-KICFYHHFSVVERVDSCASMYSRSIQGH 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	43/180 (24%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531
Ap3d1	NP_001094189.1	Adaptin_N	32..581	CDD:279882
		HEAT repeat	151..172	CDD:293787
		Cnd1	155..265	CDD:289487
		HEAT repeat	184..212	CDD:293787
		HEAT repeat	220..262	CDD:293787
		HEAT repeat	271..292	CDD:293787
		HEAT repeat	301..330	CDD:293787
		HEAT repeat	335..364	CDD:293787
		BLVR	661..803	CDD:283923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900