DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33090 and Gba2

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_001013109.2	Gene:	Gba2 / 298399	RGDID:	1305598	Length:	904	Species:	Rattus norvegicus

Alignment Length:	937	Identity:	379/937 - (40%)
Similarity:	529/937 - (56%)	Gaps:	131/937 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EESNEIAA----------VPKYGLKLKFDHVWPEKR--IQNVRASIRQTLPMVPLVCRYAA-YYW 93
            |:|.::.|          ||.:|.::...|.:.|||  .|....|:...:....:..||.. :|.
  Rat    54 EDSGQLMASYEGKARGYQVPPFGWRICLAHEFAEKRKPFQANNVSLSNLVKHFGMGLRYLKWWYR 118

  Fly    94 KVSREGRRVYMDYYYMENGKQIYGVPIGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIV 158
            |...|.:..::|.:.....:||||.|:||||||||.||:.|:|||:|:.||:|::..|:|:||||
  Rat   119 KTQVEKKTPFIDMFNSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIV 183

  Fly   159 TIKDPKGCTIFQSLLSKCSTRDKTSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSY 223
            .:: ..|.|::|.:||                     .:||:.       |.:|:..:......|
  Rat   184 CLR-RDGRTVYQQVLS---------------------LELPSV-------LRSWNWGLCGYFAFY 219

  Fly   224 TGLYPRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAVFVWSVENVCDQERKVSITFTFKN 288
            ..||||:||.|.|....|.|||||::|::||:|::||||..||||.|||..|:...|||.|:.:|
  Rat   220 HALYPRAWTVYQLPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDETLDVSIMFSMRN 284

  Fly   289 GTGNKKQDAEGGAESQ---LISEG-NAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAG 349
            |.|. :.||.||..::   |..:| ..:|:.:.......|.:..:|.|...:.::|....|||..
  Rat   285 GLGG-EDDAAGGLWNEPFRLEQDGTTVQGLLLHHPTPPNPYTMAVAARHTADTTVTYTTAFDPDS 348

  Fly   350 NGEQLWAQLKEHGQLSEHPTSEALKT---KDIGVAVCGQVALKPMASHDLEFVLAWDMPKIQFPR 411
            .|:|:|..|.:.||| :.|..::..|   :.:..|||....|.|.....|||.||||||:|.|..
  Rat   349 TGQQVWQDLLQDGQL-DSPAGQSTPTQRGEGVAGAVCASSKLLPRGRCCLEFSLAWDMPRIMFGA 412

  Fly   412 KMQTHTRYYTKYFDDSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYF 476
            |.|.|.|.||::|...||..|.:..|||.||:.||..|.|||.|:|:|.:||.|||.|:||:|||
  Rat   413 KGQVHYRRYTRFFGSDGDVAPALSHYALCQYAGWENSISAWQNPVLDDRSLPAWYKSALFNELYF 477

  Fly   477 ISDGGTIWLKC-DSSLGKELAYDDPRLA-----YGRFGYLEGHEYRMYNTYDVHFYASPALAHLW 535
            ::||||:||:. :.||.:||.....:|.     |||||||||.|||||||||||||||.||..||
  Rat   478 LADGGTVWLEVPEDSLPEELGGSMYQLRPILQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLW 542

  Fly   536 PNLQVSLQYDFKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVND 600
            |.|::|||||...|...|....|:.|..|.|.|.|.:|.:|||:||||:||:..:|.|.|||..|
  Rat   543 PKLELSLQYDMALATFKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTAD 607

  Fly   601 WKDLNTKFVLQVYRDYYVLNELAQAQSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNR 665
            |||||.|||||||||||:                                      :.|:
  Rat   608 WKDLNLKFVLQVYRDYYL--------------------------------------TGDQ----- 629

  Fly   666 KSASMYINETNGKVYLMDAIGYLKAMYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDG 730
                                |:||.|:..|.|:||..:::|||.||||||....|||||.||..|
  Rat   630 --------------------GFLKDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDGWVTTG 674

  Fly   731 PSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRD-T 794
            |||||.||||||:..|..||.:....:...::..||.:|:.:.|..||||.||.:|.|...:. :
  Rat   675 PSAYCGGLWLAAVAVMVQMAVLCGAQDVQDKFSSILCRGREAYERLLWNGRYYNYDSSSQPQSRS 739

  Fly   795 IMADQLCGHWYLKSCGF---DYEIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTK 856
            :|:||..|.|:|::||.   |.|::|..:|..|||.|::.||..|..|.:||.||.     :|
  Rat   740 VMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALKTIFELNVQAFAGGAMGAVNGM-----QP-- 797

  Fly   857 PGHVDNSNIQAEEVWPGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKR 921
            .|..|.|::|::|||.||||.|||||||||:..|.|:||.|.|:|:.:|:|:.|:||||...::.
  Rat   798 HGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQRV 862

  Fly   922 YRSIGYMRPLSIWSMQVALERRRAQRD 948
            :||:.||||||||:||:||::::.:::
  Rat   863 FRSLAYMRPLSIWAMQLALQQQQHKKN 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	115/319 (36%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	195/435 (45%)
Gba2	NP_001013109.2	GBA2_N	157..446	CDD:289023	115/319 (36%)
		DUF608	512..875	CDD:282531	193/432 (45%)
		GDE_C	<610..>738	CDD:283786	66/190 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334361
Domainoid	1	1.000	315	1.000	Domainoid score	I1246
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10859
Inparanoid	1	1.050	620	1.000	Inparanoid score	I845
OMA	1	1.010	-	-		QHG63864
OrthoDB	1	1.010	-	-		D207392at2759
OrthoFinder	1	1.000	-	-		FOG0003795
OrthoInspector	1	1.000	-	-		oto97890
orthoMCL	1	0.900	-	-		OOG6_105042
Panther	1	1.100	-	-	LDO	PTHR12654
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2650
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910