DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33090 and hpo-13

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_001379302.1	Gene:	hpo-13 / 173305	WormBaseID:	WBGene00013670	Length:	959	Species:	Caenorhabditis elegans

Alignment Length:	916	Identity:	339/916 - (37%)
Similarity:	493/916 - (53%)	Gaps:	121/916 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GLKLKFDHVWPEKRIQNVRASIRQTLPMVPLVCRYAAYYWKVSREGRRVYMDYYYMENGKQIYGV 118
            |.|.:.|....:||:...|.:..|....:|.|.||..|:.|.:.:..:::::.:.....|..|||
Worm    73 GWKARGDRKPKDKRVPFNRPTPYQIYEALPFVRRYFMYWMKHTFDKEKLFINTFQPLKHKPYYGV 137

  Fly   119 PIGGIGGGTIGRGYAGEFCRFQMRPGIYEY--NVVLANQFIVTIKDPKGCTIFQSLLSKCSTRDK 181
            |.||||.|.|||.:.|.||:|.:|||:.|:  :||.|:|||:::::...| |:|.:||....:
Worm   138 PCGGIGCGAIGRDFRGGFCKFSLRPGLVEHKVDVVAADQFILSVRENDRC-IYQKVLSAADVQ-- 199

  Fly   182 TSDPDGDPDGERTKCQLPNCSSRAKQPLSAWHSNIEDTRCSYTGLYPRSWTEYDLSHYGVRLTCR 246
                  .|.|:                ||.|..........|.||:|||||.:.:....:.:..|
Worm   200 ------RPSGQ----------------LSTWDFKFPKKNVHYRGLFPRSWTTFRVPELELTVVIR 242

  Fly   247 QVSPVIPHEYRESSLPCAVFVWSVEN--VCDQERKVSITFTFKNGTGNKKQDAE---GGAESQLI 306
            |||||:||.|.:::.|..:|:..|||  ...:|.::|:.|||:|||||::.:.|   .|.:.:..
Worm   243 QVSPVLPHNYEDTTYPVCLFLIDVENGGSASREYEISVAFTFRNGTGNRRWEREAECSGVKFETE 307

  Fly   307 SEG---------NAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFDPAGNGEQLWAQLKEHG 362
            .||         ...|||:...||.|||:|.||.......:.|.|.:|||:.||..||..||:.|
Worm   308 EEGLKPTTTAQEKISGVSLYHTISSMPCTYGLATTHREHTTTTVCERFDPSRNGAALWNHLKQTG 372

  Fly   363 QLSEHPTSEALKTKDIGVAVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYFD-- 425
            .:........:..:::.||||.:..|.|.::...::.|:|||||:.|....:::.|.||::|:
Worm   373 DVPSCEEECLINAREMAVAVCNRFTLPPNSTKTHDYALSWDMPKVHFGSVARSYHRRYTRFFEAS 437

  Fly   426 DSGDSGPRICEYALRQYSTWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSS 490
            ::|.:...:|..|||....||..|:|||.||||.:.||||||.||||:||||:||||:|.:.|.:
Worm   438 EAGSAADSLCVRALRLKDKWESEIEAWQSPILNHKKLPDWYKSAIFNELYFITDGGTVWFEFDEN 502

  Fly   491 LGKELAY-----DDPRLAYGRFGYLEGHEYRMYNTYDVHFYASPALAHLWPNLQVSLQYDFKDAI 550
            ..:...:     .|.....|||||||..||||.||||||||||.|||.|||.|::::|.:|.|.:
Worm   503 WAEHETHLSHYTKDKMKEIGRFGYLESWEYRMVNTYDVHFYASFALAELWPELEITIQSEFTDQV 567

  Fly   551 AAELNDTRKMLYDGKVMPRKVKNCVPHDLGDPDEEPFTLINCYNIHDVNDWKDLNTKFVLQVYRD 615
            ...:....:...:|.....|..:.||||||:|.:||:...|.|.:||...|||||.|:||..:||
Worm   568 YHSIEKPTRFHMEGDWANVKTASRVPHDLGNPADEPWIATNAYVMHDTGKWKDLNMKYVLTSWRD 632

  Fly   616 YYVLNELAQAQSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNRKSASMYINETNGKVY 680
            |.||:                               |:.::
Worm   633 YVVLS-------------------------------NEHED------------------------ 642

  Fly   681 LMDAIGYLKAMYASCKAIMERTIE-YDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQ 744
                  :|...:.:.:.||...:| :|:|.||:|||....|||||:|.|:|.||||..||||:|:
Worm   643 ------FLFHTWPAVRMIMLEALENWDQDGDGMIENFGKADQTYDAWQMEGVSAYCGSLWLASLR 701

  Fly   745 AMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMADQLCGHWYLKSC 809
            ....||.::........:::.|||.|:...:.||.|:|:||......|:|:|||||||:|:|:|.
Worm   702 VAIEMAGLMKDDETQQLFRNTLEKAKKVFIDTLWTGTYFRFCERSRSRETVMADQLCGYWFLQSV 766

  Fly   810 GFDY--EIYPKENVRTALKRIYDNNVMGFHEGNIGAANGFIANASEPTKP-GHVDNSNIQAEEVW 871
            ..:.  |:.|...||:||..||..||..|..|.:||.||.        || |.||...|||:|:|
Worm   767 SPELADELLPNHMVRSALDTIYRLNVCKFGNGRMGAVNGM--------KPSGVVDREYIQADEMW 823

  Fly   872 PGVVYALAATMIQEGMFEEAFQTAGGMYKTLSQRIGMNFETPEALYGEKRYRSIGYMRPLSIWSM 936
            .||.||:|:.:||:|..|:||.||.|.|.|..:..|:.::||||||..|.||:||||||||||:|
Worm   824 TGVTYAVASLLIQQGEVEKAFHTASGSYLTCFEETGLQYQTPEALYESKFYRAIGYMRPLSIWAM 888

  Fly   937 QVALER 942
            |.:|::
Worm   889 QWSLKK 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	105/330 (32%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	174/435 (40%)
hpo-13	NP_001379302.1	Glyco_hydr_116N	149..457	CDD:403436	106/332 (32%)
hpo-13	NP_001379302.1	DUF608	522..888	CDD:398386	174/434 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156055
Domainoid	1	1.000	344	1.000	Domainoid score	I563
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10859
Inparanoid	1	1.050	631	1.000	Inparanoid score	I460
Isobase	1	0.950	-	0	Normalized mean entropy	S4511
OMA	1	1.010	-	-		QHG63864
OrthoDB	1	1.010	-	-		D207392at2759
OrthoFinder	1	1.000	-	-		FOG0003795
OrthoInspector	1	1.000	-	-		otm14215
orthoMCL	1	0.900	-	-		OOG6_105042
Panther	1	1.100	-	-	O	PTHR12654
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4019
SonicParanoid	1	1.000	-	-		X2650
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890