DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33090 and Ap3d1

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_031486.1	Gene:	Ap3d1 / 11776	MGIID:	107734	Length:	1199	Species:	Mus musculus

Alignment Length:	185	Identity:	42/185 - (22%)
Similarity:	72/185 - (38%)	Gaps:	51/185 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 DQERKVSITFTFKNGTGNKKQ----DAEGGAESQLISEGNAKGVSIRQKISEMP--CSYNLACRV 333
            |||||.|.....|:....:|:    |.:...:.|:....|  |.:..::...:|  .||.|...
Mouse   912 DQERKSSRHKKKKHRKEKEKEERPRDKKKAKKKQVAPLEN--GAAAEEEEEPIPPMSSYCLLAE- 973

  Fly   334 LPEISITRCPQFDPAGNGEQLWAQLKEHGQLS-----EHPTSEALKTKDI--------------- 378
            .|.|.:|    :|       :.|.|::..|::     |:.:|..||..::
Mouse   974 SPYIKVT----YD-------IQASLQKDSQVTVSIILENQSSSFLKNMELNVLDSLNTKMTRPEG 1027

  Fly   379 -----GVAVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYFDDSG 428
                 ||.|..|  |.|..|::.:||  :.:..|...:|::....:..|  ||.|
Mouse  1028 SSVHDGVPVPFQ--LPPGVSNEAQFV--FTIQSIVMAQKLKGTLSFIAK--DDEG 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	42/185 (23%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531
Ap3d1	NP_031486.1	Adaptin_N	32..581	CDD:279882
		HEAT 1	34..71
		HEAT 2	142..179
		HEAT repeat	151..172	CDD:293787
		Cnd1	155..265	CDD:289487
		HEAT 3	180..216
		HEAT repeat	184..212	CDD:293787
		HEAT 4	218..254
		HEAT repeat	220..262	CDD:293787
		HEAT 5	257..296
		HEAT repeat	271..292	CDD:293787
		HEAT 6	298..336
		HEAT repeat	301..330	CDD:293787
		HEAT repeat	335..364	CDD:293787
		HEAT 7	337..373
		HEAT 8	375..409
		HEAT 9	521..558
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..695
		BLVR	661..803	CDD:283923
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..963		12/52 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900