DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33090 and Ap2a2

DIOPT Version :9

Sequence 1:	NP_788055.2	Gene:	CG33090 / 34835	FlyBaseID:	FBgn0028916	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_001343997.1	Gene:	Ap2a2 / 11772	MGIID:	101920	Length:	939	Species:	Mus musculus

Alignment Length:	685	Identity:	116/685 - (16%)
Similarity:	196/685 - (28%)	Gaps:	299/685 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 ISITRC--PQFDPAGNGEQLWAQLKEHGQLSEHPTSEALKTKDIGVAVCGQVALKPMASHDLEFV 399
            :.:.:|  |..|||..|...........:..|.|.|:.::..:...||..: |:..:..||.|
Mouse   262 LRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFE-AISLIIHHDSE-- 323

  Fly   400 LAWDMPKI---------QFPRKMQTHTRYYTKYFDDSGDSGPRICEYALRQYS------------ 443
                 |.:         ||.:..:|:.||...         ..:|..|..::|
Mouse   324 -----PNLLVRACNQLGQFLQHRETNLRYLAL---------ESMCTLASSEFSHEAVKTHIETVI 374

  Fly   444 ---TWERLIDAWQRPILNDETLPDWYKCAIFNQLYFISDGGTIWLKCDSSLGKELAYDDPRLAYG 505
               ..||.:...||.:                        ..::..||.|..:::..:
Mouse   375 NALKTERDVSVRQRAV------------------------DLLYAMCDRSNAQQIVAE------- 408

  Fly   506 RFGYLEGHEYRMYN-------------TYDVHFYASPAL-----------AHLWPN-LQVSLQYD 545
            ...|||..:|.:..             ..|..:|....|           ..:|.. :|:.:..|
Mouse   409 MLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRD 473

  Fly   546 FKDAIAAELNDTRKMLYDGKVMPRKVKNCVPHD-----------LGDPDEEPFTLINCYNIHDVN 599
            .....||      |.:::....|...:|.|...           .|||...|....|.
Mouse   474 DVQGYAA------KTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNL------- 525

  Fly   600 DWKDLNTKF----------VLQVYRDYYVLNELAQAQSDNASKFSSIEFID-----KESLYELYS 649
                |::||          :|..|                      |:|::     |.::.::..
Mouse   526 ----LHSKFHLCSVPTRALLLSTY----------------------IKFVNLFPEVKATIQDVLR 564

  Fly   650 QDNKRKNSADEKQQNRKSASMYINETNGKVYLMDAIGYLKAMYASCKAIMERTIEYDKDNDGLIE 714
            .|::.||:..|.||.                   |:.||:....:...|:...:|         |
Mouse   565 SDSQLKNADVELQQR-------------------AVEYLRLSTVASTDILATVLE---------E 601

  Fly   715 NTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAMATILDQPNDCLRYQDILEKGKRSLEEKLWN 779
            ....|::  :|.:            ||.|:.....:|:.|           ||:.||.....: |
Mouse   602 MPPFPER--ESSI------------LAKLKKKKGPSTVTD-----------LEETKRERSIDV-N 640

  Fly   780 GSYYRFDLSHSHRDTIMADQLCGHWYLKSCGFDYEIYPKENVRTALKRIYDNNVMGFHEGNIGA- 843
            |.......|.|...|                      |..:.          :::|     :||
Mouse   641 GGPEPVPASTSAAST----------------------PSPSA----------DLLG-----LGAV 668

  Fly   844 -----------ANGFI-------ANASEPTKPGHVDN-------SNIQAEEVWPGVVYALAATMI 883
                       ..|.:       |:|..|..||..||       :|        ||::  ...::
Mouse   669 PPAPTGPPPSSGGGLLVDVFSDSASAVAPLAPGSEDNFARFVCKNN--------GVLF--ENQLL 723

  Fly   884 QEGMFEEAFQTAGGMY-----KTLSQRIGMNFETP 913
            |.|:..|..|..|.|:     ||.:|  .:|| ||
Mouse   724 QIGLKSEFRQNLGRMFIFYGNKTSTQ--FLNF-TP 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	24/133 (18%)
CG33090	NP_788055.2	DUF608	505..937	CDD:282531	85/491 (17%)
Ap2a2	NP_001343997.1	Lipid-binding	5..80
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250\|UniProtKB:P18484	11..12
		Adaptin_N	29..591	CDD:396262	69/434 (16%)
		Phosphatidylinositol 3,4,5-trisphosphate binding. /evidence=ECO:0000250\|UniProtKB:P18484	57..61
		HEAT repeat	332..355	CDD:293787	5/31 (16%)
		HEAT repeat	369..398	CDD:293787	4/52 (8%)
		HEAT repeat	408..434	CDD:293787	4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..682		16/114 (14%)
		Alpha_adaptinC2	717..820	CDD:197886	13/44 (30%)
		Alpha_adaptin_C	826..934	CDD:367023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900