Protein Alignment CG33090 and Ap2a1

DIOPT Version :9

• Sequence 1: NP_788055.2
• Gene: CG33090 / 34835
• FlyBaseID: FBgn0028916
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_031484.1
• Gene: Ap2a1 / 11771
• MGIID: 101921
• Length: 977
• Species: Mus musculus
• Alignment Length: 765
• Identity: 132/765 - (17%)
• Similarity: 208/765 - (27%)
• Gaps: 346/765 - (45%)

  Fly   120 IGGIGGGTIGRGYAGEFCRFQMRPGIYEYNVVLANQFIVTIKDPKGCTIFQSLLSKCSTRDKTSD 184
            |..:|...:|..:|.:..|           :::|...:.::|        || .:.|..|...:.
Mouse   135 IANVGSREMGEAFAADIPR-----------ILVAGDSMDSVK--------QS-AALCLLRLYKAS 179

  Fly   185 PDGDPDGERTK------------------------CQ-----LPNCSSRAKQPLSAWHSNIEDTR 220
            ||..|.||.|.                        |:     ...|.|.|...||...|:.....
Mouse   180 PDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCISLAVSRLSRIVSSASTDL 244

  Fly   221 CSYTGLY-PRSWTEYDLSHYGVRLTCRQVSPVIPHEYRESSLPCAV---FVWSVENVCDQERKVS 281
            ..||..: |..|....|      |...|..|  |.|      ..||   .|..:|.|.
Mouse   245 QDYTYYFVPAPWLSVKL------LRLLQCYP--PPE------DAAVKGRLVECLETVL------- 288

  Fly   282 ITFTFKNGTGNKKQDAEGGAESQLISEGNAKGVSIRQKISEMPCSYNLACRVLPEISITRCPQFD 346
                      ||.|:.   .:|:.:...|||...:.:.|| :...|:..    |.:.:..|.|.
Mouse   289 ----------NKAQEP---PKSKKVQHSNAKNAILFETIS-LIIHYDSE----PNLLVRACNQL- 334

  Fly   347 PAGNGEQLWAQLKEHGQ--------------LSEHPTSEALKT------------KDIGV----- 380
                     .|..:|.:              .|...:.||:||            :|:.|
Mouse   335 ---------GQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAA 390

  Fly   381 ----AVCGQVALKPMASHDLEFVLAWDMPKIQFPRKMQTHTRYYTKYFDDSGDSGPRICEYALRQ 441
                |:|.:...|.:.|..|.::                                 ...:||:|
Mouse   391 DLLYAMCDRSNAKQIVSEMLRYL---------------------------------ETADYAIR- 421

  Fly   442 YSTWERLIDAWQRPILNDETLPD--WYKCAIFNQLYFISD--GGTIWLKCDSSLGKELAYDDPRL 502
                |.::  .:..||.::...|  ||...|.|.:....|  ...:|
Mouse   422 ----EEIV--LKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVW------------------ 462

  Fly   503 AYGRFGYLEGHEYRMY----NTYDVHFYASPALAHLWPNLQVSLQYDFKDAIAAELNDTRKMLYD 563
                        ||:.    |..||..||:..:            ::...|.|...|    |:..
Mouse   463 ------------YRVLQIVTNRDDVQGYAAKTV------------FEALQAPACHEN----MVKV 499

  Fly   564 GKVMPRKVKNCVPHDLGDPDEEP---FTLINCYNIHDVNDWKDLNTKFVLQVYRDYYVLNELAQA 625
            |..:..:..|.:   .|||...|   |:|::
Mouse   500 GGYILGEFGNLI---AGDPRSSPPVQFSLLH---------------------------------- 527

  Fly   626 QSDNASKFSSIEFIDKESLYELYSQDNKRKNSADEKQQNRKSASMYIN---ETNGKVYLMDAIGY 687
                 |||.......:..|...|.:                    :||   ||...:.     |.
Mouse   528 -----SKFHLCSVATRALLLSTYIK--------------------FINLFPETKATIQ-----GV 562

  Fly   688 LKA---MYASCKAIMERTIEYDKDNDGLIENTKMPDQTYDSWVMDGPSAYCSGLWLAALQAMSAM 749
            |:|   :..:...:.:|.:||                                |.|:::.:...:
Mouse   563 LRAGSQLRNADVELQQRAVEY--------------------------------LTLSSVASTDVL 595

  Fly   750 ATILDQ-PNDCLRYQDILEKGKRSLEEKLWNGSYYRFDLSHSHRDTIMAD 798
            ||:|:: |....|...||.|.||.      .|......|..|.|||...|
Mouse   596 ATVLEEMPPFPERESSILAKLKRK------KGPGAASALDDSRRDTSSND 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33090	NP_788055.2	GBA2_N	132..445	CDD:289023	66/380 (17%)
		DUF608	505..937	CDD:282531	53/308 (17%)
Ap2a1	NP_031484.1	Adaptin_N	29..591	CDD:366724	115/709 (16%)
		HEAT repeat	332..355	CDD:293787	3/32 (9%)
		HEAT repeat	369..398	CDD:293787	3/28 (11%)
		HEAT repeat	408..434	CDD:293787	7/65 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..702		10/32 (31%)
		Alpha_adaptinC2	755..858	CDD:197886
		Alpha_adaptin_C	864..972	CDD:367023

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900