DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF530 and Kr-h1

DIOPT Version :9

Sequence 1:	NP_065931.3	Gene:	ZNF530 / 348327	HGNCID:	29297	Length:	599	Species:	Homo sapiens
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	143/490 - (29%)
Similarity:	198/490 - (40%)	Gaps:	110/490 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    60 VDEGTPSAESVSVEELSQGRTPKADTSTDK---------------SHPCEIC---TPVLRDILQM 106
            :|.....|::|:|:     ::|..|::|.|               |...:.|   .|.|......
  Fly    30 LDISKSPAKAVAVK-----KSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATTTS 89

Human   107 IELHASPCGQKLYLGGASRDFWM----SSNLHQLQKLDNGEKLFKVDGDQASFMMNCRFHVSGKP 167
            :.|...|.      ||....|.:    .....|||..|..::      :|..|:
  Fly    90 VGLGVPPS------GGQQEHFELLQTPQQRQMQLQLQDQHQQ------EQQQFV----------- 131

Human   168 FTFGEVGRDFSATSGLLQHQ-------------VTPTIERPHSRIRHLRVPTGRKPLKYTESRKS 219
                      |....:.|||             ..||......||:             ||....
  Fly   132 ----------SYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIK-------------TEPVGG 173

Human   220 FREKSVFIQHQRADSGERP-YKCSECGKSFSQSSGFLRHRKAHGR-------------------T 264
            |...:..:...|..|..:| :||.:||.:|...|....|.|:|.:                   |
  Fly   174 FPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVST 238

Human   265 RTHECSECG--KSFSRKTHLTQHQRVHTGERPYDCSECGKSFRQVSVLIQHQRVHTGERPYECSE 327
            ...|.::.|  ....:...:.....|..|..||.|:.|.|:|...:.||:|.|.||||||:||..
  Fly   239 AAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEF 303

Human   328 CGKSFSHSTNLYRHRSAHTSTRPYECSECGKSFSHSTNLFRHWRVHTGVRPYECSECGKAFSCNI 392
            |.|.||...||..||..||..|||:|..||::|.||..|.||.|:|||.||::||.|.|.|..:.
  Fly   304 CHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSG 368

Human   393 YLIHHQRFHTGERPYVCSE--CGKSFGQKSVLIQHQRVHTGERPYECSECGKVFSQSSGLFRHRR 455
            .|:.|.|.||||:||.|.|  |||.|.....|..|.|.||||:||.|..|.:.|..:..|..||.
  Fly   369 QLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRV 433

Human   456 AHTKTKPYECSECEKSFSCKTDLIRHQTVHTGERP 490
            .|..:|.|:|:.|:::|..|.::..|...|..|.|
  Fly   434 QHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF530	NP_065931.3	KRAB	14..>55	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..88		4/19 (21%)
		C2H2 Zn finger	213..233	CDD:275368	4/19 (21%)
		C2H2 Zn finger	241..261	CDD:275368	7/19 (37%)
		COG5048	264..598	CDD:227381	97/231 (42%)
		zf-C2H2	267..289	CDD:278523	2/23 (9%)
		C2H2 Zn finger	269..289	CDD:275368	1/21 (5%)
		zf-H2C2_2	281..306	CDD:290200	8/24 (33%)
		C2H2 Zn finger	297..317	CDD:275368	8/19 (42%)
		zf-H2C2_2	310..334	CDD:290200	15/23 (65%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
		zf-C2H2	351..373	CDD:278523	11/21 (52%)
		C2H2 Zn finger	353..373	CDD:275368	10/19 (53%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		zf-H2C2_2	397..416	CDD:290200	13/20 (65%)
		C2H2 Zn finger	409..429	CDD:275368	9/21 (43%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	465..485	CDD:275368	5/19 (26%)
		zf-H2C2_2	477..502	CDD:290200	4/14 (29%)
		C2H2 Zn finger	493..513	CDD:275368
		zf-H2C2_2	505..530	CDD:290200
		C2H2 Zn finger	521..541	CDD:275368
		zf-H2C2_2	533..558	CDD:290200
		C2H2 Zn finger	549..569	CDD:275368
		zf-H2C2_2	561..586	CDD:290200
		C2H2 Zn finger	577..597	CDD:275368
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	7/19 (37%)
		COG5048	<270..420	CDD:227381	77/149 (52%)
		zf-C2H2	271..293	CDD:278523	9/21 (43%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..309	CDD:290200	14/22 (64%)
		C2H2 Zn finger	301..321	CDD:275368	9/19 (47%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	10/19 (53%)
		zf-H2C2_2	344..366	CDD:290200	13/21 (62%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..396	CDD:290200	15/25 (60%)
		C2H2 Zn finger	385..407	CDD:275368	9/21 (43%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	6/21 (29%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000