DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dyrk2 and DYRK1B

DIOPT Version :9

Sequence 1:NP_001260456.1 Gene:Dyrk2 / 34831 FlyBaseID:FBgn0016930 Length:757 Species:Drosophila melanogaster
Sequence 2:NP_004705.1 Gene:DYRK1B / 9149 HGNCID:3092 Length:629 Species:Homo sapiens


Alignment Length:577 Identity:203/577 - (35%)
Similarity:284/577 - (49%) Gaps:122/577 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 MTPSELVKKFRNY----LTDLEFEELKVYK---EVWYFGQHASKNYNKPAPTAN-----TTNLGY 214
            :.|..|...||:.    |..|..:.:|.||   ||:|..:........|..::|     ..|.||
Human    28 LLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGY 92

  Fly   215 DDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELN 279
            ||||.:|.:...:....||||..:|||||||||::|.||:|...||||||:|||.|||||.:||.
Human    93 DDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELR 157

  Fly   280 ILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIV 344
            :|:.:.:.|.:..:.::|:..:..||.|||:.|||:|.|||:|::..::.|.|::|.|:....: 
Human   158 LLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQL- 221

  Fly   345 KCLRLLY----KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVI 405
             |..||:    :.:|||||||||||||.....|:||::||||||.:.::||.||||||||||||:
Human   222 -CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVL 285

  Fly   406 LGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSR 470
            ||..|..|||||||||||.|::||.|||.|.|||:|:..|:||||:||..::..|.:.|.:|:..
Human   286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERL 350

  Fly   471 DAPR-CITNTKGRKR---SPGSKSLAHIL----------------HCQDRY--FIDFLQRCLEWD 513
            .... .:..||..::   .||::.|..:|                |....|  |.|.:.|.||::
Human   351 PGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYE 415

  Fly   514 PAERMTPDEAAHHEFLQ----------PSASSRHRS------CRMSSS----SSSSGLNSVSQKS 558
            ||.|::|..|..|.|.:          |:.||...|      |..||:    |||.|.:..|..:
Human   416 PAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN 480

  Fly   559 SCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDK 623
            ..|.:|....|..||.:..             ....|.|.||||                     
Human   481 RTYRYSNRYCGGPGPPITD-------------CEMNSPQVPPSQ--------------------- 511

  Fly   624 YNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGS 680
                                      .|....||.....||...::|:  .|||||:
Human   512 --------------------------PLRPWAGGDVPHKTHQAPASAS--SLPGTGA 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dyrk2NP_001260456.1 PKc_DYRK4 186..529 CDD:271127 161/376 (43%)
S_TKc 233..529 CDD:214567 145/321 (45%)
DYRK1BNP_004705.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..89 2/21 (10%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 69..86 2/16 (13%)
PKc_DYRK1 97..436 CDD:271128 148/340 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..629 34/167 (20%)
Interaction with RANBP9. /evidence=ECO:0000269|PubMed:14500717 480..520 13/99 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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