DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and PRPF4B

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens

Alignment Length:	472	Identity:	139/472 - (29%)
Similarity:	221/472 - (46%)	Gaps:	68/472 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 NSNSNNNNNIGSPVSSSTTNSSNGGN------------ER------GSSTKSNSSSGSGSSGNSA 148
            :||.:..:...||.||:.|.|.:..:            ||      .:|.|:..:..:....|
Human   558 DSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNN-- 620

  Fly   149 SSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLG 213
               ||.:.|...|...:|....|..|..........:.|:   |.::.:...|
Human   621 ---GSSQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKD---FKENPNLRDN------------ 667

  Fly   214 YDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDH-KTNTHVAIKIIRNKKRFLNQAVVE 277
            :.|..|.|::...:.:..||.:....|:|.|..|:||.|: :.|..||:|||||.:......:.|
Human   668 WTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKE 732

  Fly   278 LNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYN-GFSMSLIRRFCN 341
            |..|.:|.:.|.|...:.:.:..:.|.::|||:.||.:|:||.|::||...: |..:..:|.:..
Human   733 LEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQ 797

  Fly   342 SIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYV-DRKIYTYIQSRFYRSPEVI 405
            .:...|:||.:.||:|.|:||:|||:.: ..:.:|:.||||:.:| |..|..|:.|||||:||:|
Human   798 QLFLALKLLKRCNILHADIKPDNILVNE-SKTILKLCDFGSASHVADNDITPYLVSRFYRAPEII 861

  Fly   406 LGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLF---- 466
            :|..|...|||||:||.|.|||||..||||:.....|...|::.|..|..:|    |:.:|
Human   862 IGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMI----RKGVFKDQH 922

  Fly   467 FDSRDAPRCITNTKGRKR---------SPGSKSLAHILHCQD---------RYFIDFLQRCLEWD 513
            ||.......|...|..:|         :|....||.::.||.         ....|.|.:.|..|
Human   923 FDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLD 987

  Fly   514 PAERMTPDEAAHHEFLQ 530
            ||:|::.::|..|.|:|
Human   988 PAKRISINQALQHAFIQ 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	117/367 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	110/320 (34%)
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583		8/23 (35%)
		STKc_PRP4	686..1003	CDD:271037	111/321 (35%)
		S_TKc	694..1003	CDD:214567	109/313 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810