DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and DYRK4

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001358230.1	Gene:	DYRK4 / 8798	HGNCID:	3095	Length:	635	Species:	Homo sapiens

Alignment Length:	487	Identity:	245/487 - (50%)
Similarity:	317/487 - (65%)	Gaps:	27/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 KCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNY 221
            |....:|.:|.:|.|:|.|:..|..|:..|.|:|:.|..|.|....|...:.|:   :||::|.|
Human   146 KQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTS---FDDEHGFY 207

  Fly   222 KIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELRE 286
            ..:.|||||:|||:||.|||||||||.:.||||.|..||:|||||||||..||::||.||:.||:
Human   208 LKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRK 272

  Fly   287 KDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLY 351
            ||.|.::||:||.|:.|||.|.||||||:.:|||||:|.||:.|||:|::|||..|::|||::|.
Human   273 KDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLS 337

  Fly   352 KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDM 416
            .|.|||||||||||:|.|:|.:|:||||||||||..:|:|||||||||||||||||..|..||||
Human   338 VEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDM 402

  Fly   417 WSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTKG 481
            ||||||.||||||:|||||||||||||||||||||||...|..|.||:.||||:..|:.|||.:|
Human   403 WSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRG 467

  Fly   482 RKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSS 546
            :||.|.||.|..:|...|..|:|||:|||.|:|:.|||||:|..|.::..|.:.:.:....:...
Human   468 KKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRK 532

  Fly   547 SSSGLNSVSQK---SSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQ 608
            |:|...|.::|   ..|:..|..:.        .||.         .||.|::..|..    |.|
Human   533 SNSFFPSETRKDKVQGCHHSSRKAD--------EITK---------ETTEKTKDSPTK----HVQ 576

  Fly   609 SNGHLPDIKLSASDKYNSMQKVAVRSKITSSV 640
            .:|...|.....:|.....|.|....|..::|
Human   577 HSGDQQDCLQHGADTVQLPQLVDAPKKSEAAV 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	214/342 (63%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	196/295 (66%)
DYRK4	NP_001358230.1	PKc_DYRK4	175..515	CDD:271127	214/342 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151391
Domainoid	1	1.000	416	1.000	Domainoid score	I662
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37858
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1541
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		oto89067
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790