Protein Alignment Dyrk2 and DYRK3

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_003573.2
• Gene: DYRK3 / 8444
• HGNCID: 3094
• Length: 588
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 236/588 - (40%)
• Similarity: 328/588 - (55%)
• Gaps: 99/588 - (16%)

  Fly    67 LCNGS-----RRLDGHNNHVAANENTVTTTSLNGNGN------------------GNGNSNSNNN 108
            |||.|     |||:            :||....|:..                  ||..||:..:
Human    50 LCNPSEPPPPRRLN------------MTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQS 102

  Fly   109 NNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRN 173
            :.|......|.|.|....::..::.||||||.:...               .|:||.:.:|::::
Human   103 DGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKV---------------VPLTPEQALKQYKH 152

  Fly   174 YLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEV 238
            :||..|..|:..|.|:::.|.:|.|.:   .......|.||||.:|.|..:..||:|:|||:|::
Human   153 HLTAYEKLEIINYPEIYFVGPNAKKRH---GVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKI 214

  Fly   239 IGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTY 303
            |||||||||.|..|||...:||:|::||:|||..||..|:.||:.|:::|..||.||||||:...
Human   215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFT 279

  Fly   304 FRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLK 368
            ||.|:|:.|||:|::||||||||.:.|||:.|:|:|..||::.|..|:|..||||||||||||||
Human   280 FRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLK 344

  Fly   369 QRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLF 433
            ..|.||.|||||||||:..:|:||||||||||:||:|||.:|.|.||:||.|||||||.||.|||
Human   345 HHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLF 409

  Fly   434 PGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPR-CITNT--------------KGRK 483
            |||:|.:||||:||:||:||..|:..::|.:.|.:|:..|| |...|              :|:|
Human   410 PGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKK 474

  Fly   484 RS-PGSKSLAHILH-CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSS 546
            |. ||||.....|. |.|..||:||:|||.|||:.|:||.:|..|.::..|...     .:::..
Human   475 RGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPR-----PLTTID 534

  Fly   547 SSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNG 611
            ..||...|:..|:........|    |||            .||...|:...        :::||
Human   535 KVSGKRVVNPASAFQGLGSKLP----PVV------------GIANKLKANLM--------SETNG 575

  Fly   612 HLP 614
            .:|
Human   576 SIP 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	189/359 (53%)
		S_TKc	233..529	CDD:214567	173/312 (55%)
DYRK3	NP_003573.2	Disordered. /evidence=ECO:0000305|PubMed:23415227	1..188		37/167 (22%)
		PKc_DYRK2_3	143..522	CDD:271126	195/381 (51%)
		S_TKc	209..522	CDD:214567	173/312 (55%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:29973724	468..481		5/12 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9448
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750