Protein Alignment Dyrk2 and Hipk3

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: XP_008760294.2
• Gene: Hipk3 / 83617
• RGDID: 619884
• Length: 1220
• Species: Rattus norvegicus
• Alignment Length: 721
• Identity: 184/721 - (25%)
• Similarity: 296/721 - (41%)
• Gaps: 202/721 - (28%)

  Fly    65 PQLCNGSRRLDGHNNHVAA----NENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVS--SSTTNSS 123
            ||.|...|:.:..:||..|    :|.::....|              ..|:|:||:  ::||.|
  Rat   130 PQRCGLKRKSEELDNHSGAMQIVDELSILPAML--------------QTNMGNPVTVVTATTGS- 179

  Fly   124 NGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKE 188
                      |.|.:||
  Rat   180 ----------KQNCTSG------------------------------------------------ 186

  Fly   189 VWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRA 250
                                         .|:|::::|:   .:...||:|:.:|:|:||||::.
  Rat   187 -----------------------------EGDYQLVQHEVLCSVKNTYEVLDFLGRGTFGQVVKC 222

  Fly   251 LDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELM 315
            ....||..|||||::|...:..|..:|::||..|..::|| .:|.:...:....|.|.|:.||::
  Rat   223 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEML 286

  Fly   316 SLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVI 378
            ..|||:.:|:|.::...:.:||.....:...|:.|....:||.|||||||:|..  |....:|||
  Rat   287 EQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVI 351

  Fly   379 DFGSSCYVDRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQL 442
            ||||:.:|.:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||..|.:|:
  Rat   352 DFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 416

  Fly   443 ACIMEVLGLPPKVLISVARRRRLFF----------------DSRDAPRCITNTKGRKRSPGSKSL 491
            ..|.:..|||.:.|::|..:...||                :..:|...:.:.:.||..  ..||
  Rat   417 RYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAETGMKSKEARKYI--FNSL 479

  Fly   492 AHILH----------------CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEF------LQPSAS 534
            ..|:|                ...|.|:..|::.|..|...|:||.|..:|.|      |....|
  Rat   480 DDIVHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPIETLNHPFVSMKHLLDFPHS 544

  Fly   535 SRHRSC----RMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKS 595
            |..:||    .:..|.||...|:.|:.|.....:  |.|| ..:.|:.|....:.:.|:.|:..|
  Rat   545 SHVKSCFHIMDICKSPSSCETNNHSKMSLLRPVA--SNGT-AALAANFTKVGTLRSQALTTSAHS 606

  Fly   596 --RQQPPSQSHGHAQSNGHLPDIKLSASDKYN--------SMQKV-AVRSKITS----------S 639
              ....|.|: |.||         ....|.::        ::|.: |...|.||          .
  Rat   607 VVHHGIPLQA-GTAQ---------FGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDNTVPL 661

  Fly   640 VSDLESVQQYSLH-RIYGGVGSGSTHHVSSAATRKHLPG-------TGSGIVGAMS-SKYGSSTL 695
            |:...:||...:. .:.....||.|..:...|.::..|.       |..|:.|:.. ..:|....
  Rat   662 VTQAPAVQPLQIRPGVLSQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDWGKMIP 726

  Fly   696 AHNHHN 701
            ..||:|
  Rat   727 HSNHYN 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	119/386 (31%)
Hipk3	XP_008760294.2	None