Protein Alignment Dyrk2 and YAK1

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_198447.2
• Gene: YAK1 / 833590
• AraportID: AT5G35980
• Length: 956
• Species: Arabidopsis thaliana
• Alignment Length: 775
• Identity: 226/775 - (29%)
• Similarity: 335/775 - (43%)
• Gaps: 221/775 - (28%)

  Fly   143 SSGNSASSTGS-GELKCNTPMTPSELVKKFRNYLTD------------------LEFEELKVYK- 187
            |.|.:|:..|. |.:..:||..|.:||  |:.||..                  |..:.::.||
plant     7 SDGAAAARAGEIGSIGVSTPWKPIQLV--FKRYLPQNGSASKVHVAVKKPVVVRLTRDLVETYKI 69

  Fly   188 ---EVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAF-------RYEILEVIGKG 242
               :..|.|:...|.| ...|:....|.|:  ||.||.:|...:..|       ||.:.:::|.|
plant    70 CDPQFKYRGELNPKRY-LTTPSVGVNNDGF--DNVNYDLILAVNDDFCSSDSRQRYIVKDLLGHG 131

  Fly   243 SFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREK-DADGSHNVIHMLDYTYFRK 306
            :||||.:....:||:.||:|:|:|:..:..||:||::||..|.:| |.:..::::.:.||...:.
plant   132 TFGQVAKCWVPETNSFVAVKVIKNQLAYYQQALVEVSILTTLNKKYDPEDKNHIVRIYDYFLHQS 196

  Fly   307 HLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL-KQR 370
            ||||.|||:.:|||||||.|.:.|.|:|:::.|...|:..|.||....||||||||||||| ...
plant   197 HLCICFELLDMNLYELIKINQFRGLSLSIVKLFSKQILLGLALLKDAGIIHCDLKPENILLCASV 261

  Fly   371 GSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPG 435
            ..:.||:|||||:|..|:.:|:|||||:||||||:||.||.|||||||.|||:|||:.|.|||||
plant   262 KPTEIKIIDFGSACMEDKTVYSYIQSRYYRSPEVLLGYQYTTAIDMWSFGCIVAELFLGLPLFPG 326

  Fly   436 ENEVEQLACIMEVLG-LPPKVLISVARRRRLFFDSRDAPRCITN--------TKG---------- 481
            .:|.:.|..::|:|| .||..::..|:....||      :|:.:        |.|
plant   327 GSEFDILRRMIEILGKQPPDYVLKEAKNTNKFF------KCVGSVHNLGNGGTYGGLKSAYMALT 385

  Fly   482 -------RKRSP-------GSKSLAHIL----------------HCQDRY-FIDFLQRCLEWDPA 515
                   .|:.|       ..|:|..|:                ..|.|. .||||:..:|:|||
plant   386 GEEFEAREKKKPEIGKEYFNHKNLEEIVKSYPYKINLPEDDVVKETQIRLALIDFLKGLMEFDPA 450

  Fly   516 ERMTPDEAAHHEF----------------------------------------LQPSASSR---- 536
            :|.:|.:||.|.|                                        |.|..|.|
plant   451 KRWSPFQAAKHPFITGEPFTCPYNPPPETPRVHVTQNIKVDHHPGEGHWFAAGLSPHVSGRTRIP 515

  Fly   537 -HRS--CRMSSSSSSSGLNSVSQKSSCYS------------------FSEISP------------ 568
             |.|  .:|...|.::...|:....| |:                  |:..||
plant   516 MHNSPHFQMMPYSHANSYGSIGSYGS-YNDGTIQDNSYGSYGGTGNMFAYYSPVNHPGLYMQNQG 579

  Fly   569 -----GT--------------NGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGH-AQSNGH- 612
                 ||              |||.... ||.:|.:.|.:...|...|..|:.::.. |.|.||
plant   580 GVSMLGTSPDARRRVMQYPHGNGPNGLG-TSPSAGNFAPLPLGTSPSQFTPNTNNQFLAGSPGHH 643

  Fly   613 ------------LPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVG-SGSTH 664
                        .|..|::|..:.|............|..|.|...|.:.:...|...| ||
plant   644 GPTSPVRNSCHGSPLGKMAAFSQINRRMSAGYSGGSQSQDSSLSQAQGHGMDNFYQNEGYSG--- 705

  Fly   665 HVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHNVTHHNASTA------TIATTTHH 718
            ..|.:.:|:.|   .||:.....:: |.:||:..:.  ||:||:::      ..::|.||
plant   706 QFSGSPSRRQL---DSGVKNRKQTQ-GGTTLSTGYS--THNNANSSLRSNMYNPSSTAHH 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	155/445 (35%)
		S_TKc	233..529	CDD:214567	139/387 (36%)
YAK1	NP_198447.2	PKc_YAK1	122..464	CDD:271114	138/347 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		otm3032
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710