DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and AT2G40120

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_181541.1	Gene:	AT2G40120 / 818603	AraportID:	AT2G40120	Length:	570	Species:	Arabidopsis thaliana

Alignment Length:	533	Identity:	163/533 - (30%)
Similarity:	244/533 - (45%)	Gaps:	102/533 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VTTTSLNGNGNGNG-NSNSNNNNNIGSPVSSSTT---NSSNGGNERGSSTKSNSSSGSGSSGNSA 148
            :|.:|...:..|:| ||.|:::::....:.|||:   :||...|..|.|  |:||.|....|.:.
plant    52 ITASSRPSDSGGDGSNSKSSSSDDEFVSLDSSTSGFCSSSGFVNPYGDS--SSSSDGQSQFGTAR 114

  Fly   149 SSTGSGELKCNTP-------MTPSELVKKFR-------------NYLTDLEFE-ELKVYKEVWYF 192
            :.....|...:..       |:|:     ||             .::||.:|| .|.||......
plant   115 TYPEWSEFYLHNETEDEDEFMSPA-----FRESDCFILPENAEDKFITDNQFENSLGVYDRSSSQ 174

  Fly   193 GQ--HASKNY-NKP------------------APTANTTNLGYD--------------------- 215
            |.  .||.:| :||                  ....|.|:...|
plant   175 GSLTEASLDYLDKPFLLDIGLEDKTDELDLKTGDQLNVTDEEVDVVHEVEDEYEVFNLRIIHWKN 239

  Fly   216 ----DDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVV 276
                ::|.:..|:.:..|..||.|.|.||..:|.:|::|.|......|.:|||:|.|.|.:|::.
plant   240 RTGFEENKDLPIVINTVIGGRYYITEYIGSAAFSKVVQAQDLHNGVDVCLKIIKNDKDFFDQSLD 304

  Fly   277 ELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNG----FSMSLIR 337
            |:.:|..:.:.|....|:::.:.||.|.::||.|..||:..||||..|.|..:|    |::|.::
plant   305 EIKLLKHVNKHDPADEHHILRLYDYFYHQEHLFIVCELLRANLYEFQKFNQESGGEPYFNLSRLQ 369

  Fly   338 RFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSP 402
            ......:..|..|:...||||||||||||:|.....::|:||.||||:....:..|:|||.||:|
plant   370 VITRQCLDALVFLHGLGIIHCDLKPENILIKSYKRCAVKIIDLGSSCFRSDNLCLYVQSRSYRAP 434

  Fly   403 EVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFF 467
            ||||||.|...||:||||||||||.:|..|||.|.....||.|:.|||.....::...:....:|
plant   435 EVILGLPYDEKIDLWSLGCILAELCSGEVLFPNEAVAMILARIVAVLGPIETEMLEKGQETHKYF 499

  Fly   468 -----------DSRDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMTPD 521
                       :|.:....||.         ..||...|...|..|:||::..|:.:|..|.|..
plant   500 TKEYDLYHLNEESNEIEYIITE---------ESSLEEQLQVSDELFLDFVRTLLDINPLRRPTAL 555

  Fly   522 EAAHHEFLQPSAS 534
            ||.:|.:|..|:|
plant   556 EALNHPWLSSSSS 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	129/403 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	115/310 (37%)
AT2G40120	NP_181541.1	PKc_DYRK_like	261..563	CDD:271035	115/310 (37%)
AT2G40120	NP_181541.1	S_TKc	261..563	CDD:214567	115/310 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810