DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and hipk3a

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_021326178.1	Gene:	hipk3a / 564413	ZFINID:	ZDB-GENE-061207-54	Length:	1276	Species:	Danio rerio

Alignment Length:	556	Identity:	159/556 - (28%)
Similarity:	254/556 - (45%)	Gaps:	114/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 ERGSSTKSNSSSGSGSSGNSASSTGS-----------------GELKCNTPMTPSELVKKFRNYL 175
            |.|...|| ..||..|.|:|.||.|:                 |..||.......|:    .|..
Zfish   110 EVGVEEKS-GDSGQNSQGSSRSSGGAPEGVRRKERSGGLNSDEGTQKCGFKCKGQEI----ENSK 169

  Fly   176 TDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGY--------------DDDNGNYKIIEH 226
            :.::..|           :|::.....|....:||.:|.              ...:|:|::::|
Zfish   170 SIMQIVE-----------EHSTLPAMLPTNVGSTTAVGVAPPEQKGTGTGAVNGTGDGDYQLVQH 223

  Fly   227 D---HIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKD 288
            :   .:...||:||.:|:|:||||::.....||..||:||::|...:..|..:|::||..|..::
Zfish   224 EVLCSMKHTYEVLEFLGRGTFGQVVKCWKRGTNEIVAVKILKNHPSYARQGQIEVSILARLSGEN 288

  Fly   289 ADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKE 353
            |: .||::...:....|.|.|:.||::..|||:.:|:|.::...:.:||.....:...|:.|...
Zfish   289 AE-EHNLVRAFECFQHRSHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSL 352

  Fly   354 NIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYVDRKI-YTYIQSRFYRSPEVILGLQYGTAID 415
            .:||.|||||||:|..  |....:|||||||:.:|.:.: .||:|||:||:||:||||.:..|||
Zfish   353 GLIHADLKPENIMLVDPVRQPFRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAID 417

  Fly   416 MWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISV-ARRRRLFFDSRDAPRC---I 476
            ||||||::|||:.|:||:||..|.:|:..|.:..|||.:.|::| .:..|.|....|:|..   :
Zfish   418 MWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKTARFFCKESDSPYTAWRL 482

  Fly   477 TNTKGRKRSPGSKS---LAHILHCQD-----------------------RYFIDFLQRCLEWDPA 515
            ..|:..:...|.||   ..:|..|.|                       |.|:|.|:..|..|..
Zfish   483 KTTEEHEAETGLKSKEARKYIFSCLDDIGHVNLMLNMEGCDQLAEKADRREFVDLLKMMLMIDAD 547

  Fly   516 ERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYS-----------FSEISPG 569
            :|:.|.:|..|.|:..........|           |.|   .||:.           |..::..
Zfish   548 QRIAPSDALTHPFVTMQHLMDFPHC-----------NHV---QSCFHIMDVCHLRTSIFDTLNRN 598

  Fly   570 TNGPVVASITSTTAVHNAAIA----TTTKSRQQPPS 601
            ...|::..:|..:| .|..:|    .:..|:..|||
Zfish   599 KAPPLMKPVTLPSA-PNITVAFNKMPSVHSQTLPPS 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	125/392 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	117/328 (36%)
hipk3a	XP_021326178.1	PKc_like	232..561	CDD:328722	117/329 (36%)
		NUT	601..>737	CDD:315542	9/34 (26%)
		Atrophin-1	<970..1274	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810