DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk2 and clk2a

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001038344.1	Gene:	clk2a / 558981	ZFINID:	ZDB-GENE-030131-298	Length:	526	Species:	Danio rerio

Alignment Length:	355	Identity:	114/355 - (32%)
Similarity:	195/355 - (54%)	Gaps:	32/355 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 DDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKT-NTHVAIKIIRNKKRFLNQAVVEL 278
            ||:.|:......|.:..||||:..:|:|:||:|::.:||:. ..|||:|||:|.:::...|.:|:
Zfish   169 DDEEGHLICRSGDVLQERYEIVSTLGEGTFGRVMQCIDHRRGGAHVALKIIKNVEKYKEAARLEI 233

  Fly   279 NILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSI 343
            |:|:.:.|||.:.::..:.|.|:..:..|:||:|||::|:.::.:|:|||..:|::.:|.....:
Zfish   234 NVLERINEKDPENNNLCVQMFDWFDYHGHMCISFELLALSTFDFLKENNYLPYSINQVRHMAYQV 298

  Fly   344 VKCLRLLYKENIIHCDLKPENILL------------KQRG-----SSSIKVIDFGSSCYVDRKIY 391
            ...::.|::..:.|.||||||||.            |:|.     :::::|:||||:.:......
Zfish   299 CLAVKFLHENKLTHTDLKPENILFVNSDYTVTYNVEKKRDERTVKNTAVRVVDFGSATFDHEHHS 363

  Fly   392 TYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVL 456
            |.:.:|.||:|||||.|.:....|:||:|.||.|.|.||.||...:..|.||.:..:||..|..:
Zfish   364 TIVSTRHYRAPEVILELGWSQPCDVWSIGSILFEYYLGFTLFQTHDNREHLAMMERILGPVPSRM 428

  Fly   457 ISVARRRRLFFDSR-------DAPRCI-TNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWD 513
            |...|:::.|:..|       .|.|.: .|.|..:|...|::..|      ....|.::..||::
Zfish   429 IRKTRKQKYFYRGRLDWDENSSAGRYVRENCKPLRRYLLSEAEEH------HQLFDLIEAMLEYE 487

  Fly   514 PAERMTPDEAAHHEFLQPSASSRHRSCRMS 543
            |::|:|...|..|.|.|...||...|...|
Zfish   488 PSKRLTLAAALRHPFFQSGISSSELSAGKS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	108/339 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	103/321 (32%)
clk2a	NP_001038344.1	DUF1777	34..>117	CDD:285811
		PRP38_assoc	<37..104	CDD:289628
		PKc_CLK2	174..503	CDD:271117	105/334 (31%)
		S_TKc	187..503	CDD:214567	103/321 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910