Protein Alignment Dyrk2 and dyrk2

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: XP_005164697.1
• Gene: dyrk2 / 557602
• ZFINID: ZDB-GENE-030131-2804
• Length: 598
• Species: Danio rerio
• Alignment Length: 618
• Identity: 251/618 - (40%)
• Similarity: 343/618 - (55%)
• Gaps: 113/618 - (18%)

  Fly    60 SRLDLPQLCNGSRRLDGHNN-------HVA--------------ANENTVTTTSLNGNGNGNGNS 103
            |.:.||.|.|.:....|.|.       ||.              :|:.||.|:..||.
Zfish    55 SPVTLPPLRNSNSLTAGGNKYTMNDHLHVGNHQQIHVQQLFEENSNKRTVLTSQPNGL------- 112

  Fly   104 NSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCN-TPMTPSEL 167
                     :||..:           |.:........|.....|::|..|.|.|.. .|:||.:.
Zfish   113 ---------TPVGRA-----------GLAMPEKQQEISQCRQGSSTSIKSTESKPKPAPLTPEQA 157

  Fly   168 VKKFRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFR 232
            :|::.:.|:..|.:|:..|.|:::.|.:|.|   :......:.|.|||||.|:|..:.|||||:|
Zfish   158 MKQYMSKLSVFEHQEILSYTEIYFIGPNAKK---RQGVVGGSNNGGYDDDQGSYIHVPHDHIAYR 219

  Fly   233 YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIH 297
            ||:|:||||||||||::|.|||.:.|||:|::||:|||..||..|:.||:.||::|.|.:.||||
Zfish   220 YEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDSTMNVIH 284

  Fly   298 MLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKP 362
            ||:...||.|:|:||||:|:|||||||||.:.|||:.|:|:|.:||::||..|:|..||||||||
Zfish   285 MLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHKNRIIHCDLKP 349

  Fly   363 ENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELY 427
            |||||||:|.|.|||||||||||..:::||||||||||:||||||.:||..|||||||||||||.
Zfish   350 ENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELL 414

  Fly   428 TGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTK----------GR 482
            ||:||.|||:|.:||||::|:||:|.:.|:..::|.:.|..|:..||..|.|.          ||
Zfish   415 TGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKGHPRYCTVTTLPDASVVLNGGR 479

  Fly   483 KR------SPGSKSLAHILH-CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSC 540
            .|      .|||:.....|. |.|..|:|||::||||||::||||.:|..|.:|      |.|..
Zfish   480 SRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDPSQRMTPSQALRHPWL------RRRLP 538

  Fly   541 RMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHG 605
            :                          |.|....|..||..|.      |.|:.|:..|||.|..
Zfish   539 K--------------------------PPTEKTTVKRITEGTG------AITSISKLPPPSGSAT 571

  Fly   606 HAQSNGHLPDIKLSASDKYNSMQKVAVRSKITS 638
            ..::|      ....:|...::|:..|..|:.|
Zfish   572 KLRTN------LAQMTDANGNIQQRTVLPKLVS 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	198/359 (55%)
		S_TKc	233..529	CDD:214567	179/312 (57%)
dyrk2	XP_005164697.1	PKc_DYRK2_3	154..533	CDD:271126	203/381 (53%)
		S_TKc	220..533	CDD:214567	179/312 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750