Protein Alignment Dyrk2 and hipk2

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001093455.3
• Gene: hipk2 / 557551
• ZFINID: ZDB-GENE-031125-4
• Length: 1228
• Species: Danio rerio
• Alignment Length: 662
• Identity: 187/662 - (28%)
• Similarity: 302/662 - (45%)
• Gaps: 138/662 - (20%)

  Fly    51 LRRDVRLSGSRLDLPQLCNGSRRLDGHNNHVAA-NEN-----TVTTTSLNGNGNGNGNSNSNNNN 109
            |:.....|..:|.:.|.||..  :.|:..|... ::|     :|....:||......||:.:...
Zfish    20 LQSSAFFSVKKLKVEQSCNWD--MTGYGTHSKVYSQNSKQSVSVAPVGINGASLQVSNSSLSYEQ 82

  Fly   110 NIGSP-------VSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGEL-----KCNTPM 162
            .:..|       |:|:::.|...|...||:    .||||||.|::.:...:..|     :|....
Zfish    83 ALLFPAGSGHIVVASASSTSGAAGQLLGST----GSSGSGSGGHNLTRRSTVSLLDTYQRCGLKR 143

  Fly   163 TPSELVKKFRNYLTDLEFEELKVYKEVWYFGQ----HASKNYNKPAP---------------TAN 208
            ...||.....:                   |.    |..:....|||               ||:
Zfish   144 KSEELDNNNGS-------------------GSGSSVHVVEEQQPPAPMIQNNVQSGATVATATAS 189

  Fly   209 TT----NLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRN 266
            ||    |.|.:.: |:|::::|:   .:...||:||.:|:|:||||::.....|:..|||||::|
Zfish   190 TTATSKNSGANSE-GDYQLLQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKN 253

  Fly   267 KKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGF 331
            ...:..|..:|::||..|..:.|| .:|.:...:....:.|.|:.||::..|||:.:|:|.::..
Zfish   254 HPSYARQGQIEVSILARLSTESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPL 317

  Fly   332 SMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL--KQRGSSSIKVIDFGSSCYVDRKI-YTY 393
            .:..||.....:...|..|....:||.|||||||:|  ..|....:|||||||:.:|.:.: .||
Zfish   318 PLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPARQPYRVKVIDFGSASHVSKAVCSTY 382

  Fly   394 IQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLIS 458
            :|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|||.:.|:|
Zfish   383 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLS 447

  Fly   459 VARRRRLFFDSRDAPRCITNTKGRKRSP-------GSKS---LAHILHCQD-------------- 499
            ...:...|| :||...  |....|.::|       |.||   ..:|.:|.|
Zfish   448 AGTKTTRFF-NRDPDS--TYPLWRLKTPEDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGS 509

  Fly   500 ---------RYFIDFLQRCLEWDPAERMTPDEAAHHEF------LQPSASSRHRSCRMSSSSSSS 549
                     |.|||.|.:.|..|..:|:||.|..:|.|      |....|:..:||..:......
Zfish   510 DMLAEKADRREFIDLLTKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKR 574

  Fly   550 GLN---SVSQKSSCYSFSEISPGTNGPVVASITST-----TAVHNAAIATTTKSRQQPPSQSHGH 606
            .:|   :|:|..:.: .:.::|.|:    .::|.|     ..||:.|      :...|.|.|...
Zfish   575 RVNMYDTVNQSKTPF-ITHVAPSTS----TNLTMTFNNQLNTVHSQA------TNLAPSSTSATL 628

  Fly   607 AQSNGHLPDIKL 618
            :.:|   ||:.:
Zfish   629 SLTN---PDVSI 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	135/410 (33%)
		S_TKc	233..529	CDD:214567	121/337 (36%)
hipk2	NP_001093455.3	STKc_HIPK	220..548	CDD:271113	120/331 (36%)
		S_TKc	220..548	CDD:214567	120/331 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840